Search Hotels in South Main, Houston
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Our top choices for South Main hotels
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (837 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is ฿2,578
฿3,015 total
includes taxes & fees
25 Mar - 26 Mar
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,008 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is ฿3,812
฿4,460 total
includes taxes & fees
25 Feb - 26 Feb
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,004 reviews)
"Courteous staff, clean room, quite property"
Javier
The price is ฿2,784
฿3,258 total
includes taxes & fees
25 Mar - 26 Mar
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"Easy access to stadium "
Richard
The price is ฿2,169
฿2,537 total
includes taxes & fees
23 Mar - 24 Mar
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,224 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is ฿3,098
฿3,625 total
includes taxes & fees
23 Mar - 24 Mar
Baymont by Wyndham Houston Hobby Airport
Baymont by Wyndham Houston Hobby Airport18.4 km from South Main
8.6 out of 10, Excellent, (897 reviews)
"Very clean !! every thing is new. breakfast also very good, we will comeback to stay again."
LEI
The price is ฿2,540
฿2,988 total
includes taxes & fees
3 Mar - 4 Mar
Fairfield Inn & Suites Houston Intercontinental Airport
Fairfield Inn & Suites Houston Intercontinental Airport30.6 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"Great place, nice room"
Lester
The price is ฿2,739
฿3,260 total
includes taxes & fees
27 Mar - 28 Mar
Holiday Inn Express & Suites Houston North - IAH Area by IHG
Holiday Inn Express & Suites Houston North - IAH Area by IHG28.9 km from South Main
8.4 out of 10, Very good, (943 reviews)
"Yes room is clean and staff is friendly."
Jia Ning
The price is ฿2,454
฿2,870 total
includes taxes & fees
24 Mar - 25 Mar
Four Points by Sheraton Houston Intercontinental Airport
Four Points by Sheraton Houston Intercontinental Airport29.9 km from South Main
8.4 out of 10, Very good, (1,012 reviews)
"The staff was friendly and the hotel was clean"
Lisa
The price is ฿2,739
฿3,204 total
includes taxes & fees
15 Mar - 16 Mar
Comfort Suites Houston West at Clay Road
Comfort Suites Houston West at Clay Road22.8 km from South Main
8.4 out of 10, Very good, (1,007 reviews)
"Friendly staff, breakfast excellent perfect location! Will definitely stay here again"
wanda
The price is ฿2,449
฿2,865 total
includes taxes & fees
5 Mar - 6 Mar
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very good, (1,016 reviews)
"Place was amazing and the staff were great!!!"
Marlene
The price is ฿2,452
฿2,885 total
includes taxes & fees
27 Mar - 28 Mar
Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very good, (1,318 reviews)
"Clean, quiet, amazing stay with great price."
Amy
The price is ฿2,417
฿2,827 total
includes taxes & fees
25 Feb - 26 Feb
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.6 out of 10, (1,021 reviews)
"Staff was very friendly , room was very clean "
Charlette
The price is ฿1,673
฿1,957 total
includes taxes & fees
25 Feb - 26 Feb
Hampton Inn Houston-Brookhollow
Hampton Inn Houston-Brookhollow20.4 km from South Main
8.2 out of 10, Very good, (1,005 reviews)
"The staff is awesome! What a great place to stay! "
Cynthia
The price is ฿2,743
฿3,210 total
includes taxes & fees
23 Mar - 24 Mar
WoodSpring Suites Houston Northwest
WoodSpring Suites Houston Northwest23.8 km from South Main
7.6 out of 10, Good, (533 reviews)
"Great experience!!"
Bryant
The price is ฿1,704
฿1,959 total
includes taxes & fees
25 Feb - 26 Feb
Hilton Houston North
Hilton Houston North30.5 km from South Main
8.4 out of 10, Very good, (1,008 reviews)
"I had a great stay at this hotel. The room was clean and comfortable."
Victor
The price is ฿3,716
฿4,348 total
includes taxes & fees
22 Mar - 23 Mar
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD28.7 km from South Main
9.0 out of 10, Wonderful, (995 reviews)
"The hotel was very clean the staff was amazing. We enjoyed our stay"
Teanna
The price is ฿3,024
฿3,538 total
includes taxes & fees
22 Mar - 23 Mar
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG9.6 km from South Main
8.0 out of 10, Very good, (1,002 reviews)
"Clean room, friendly and responsive staff"
Clara
The price is ฿3,439
฿4,024 total
includes taxes & fees
3 Mar - 4 Mar
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,012 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
Wayne
The price is ฿3,531
฿4,172 total
includes taxes & fees
2 Mar - 3 Mar
Home2 Suites by Hilton Houston IAH Airport Beltway 8
Home2 Suites by Hilton Houston IAH Airport Beltway 829.9 km from South Main
8.4 out of 10, Very good, (816 reviews)
"Great room close to airport "
Kelli
The price is ฿2,729
฿3,193 total
includes taxes & fees
22 Mar - 23 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,008 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,224 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 837 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,002 reviews | View | ||||||
 Comfort Suites Near Texas Medical Center - NRG Stadium | 9.0 Wonderful 6 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
