Santo Spirito Travel Guide
Florence
Visit Santo Spirito
Stay near popular Santo Spirito attractions
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Reserved Entrance Ticket to the Medici Chapel
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence: Reserved Entry Ticket to Bargello Museum
Best of Florence Tour with David at Accademia & Duomo (with VIP option)
Top hotels in Santo Spirito
Hotel Horto Convento
"We were upgraded to the Hotel Della Calza SPA. This turned out to be a fantastic place to end a long hot day. The SPA ameneties were part of the package and it was truly a big benefit for recovering from the walking and bustle of all the crowds."
Reviewed on 10 Sept 2026
La Torre Del Cestello
"Exactly as advertised. Staff was very helpful."
Reviewed on 10 Sept 2026
UNA Hotels Vittoria Firenze
"The entrance, the building, the lobby looked very well and promising. Room was small but ok. The shower was terrible, poor mainteined. Room decoration looked agressive. Breakfast was great. Location little far from downtown"
Reviewed on 6 Sept 2026
Casa Santo Nome di Gesù
"Beautiful hotel in great location. Staff really helpful with local knowledge. Communal fridge available at reception, which was great for storing drinks."
Reviewed on 27 Aug 2026
Palazzo Mannaioni Suites
"Nice suite but very noisy, there was construction going on and they started rummaging at 6:00 in the morning. People above us were constantly moving furniture around till 12:30 pm , so annoying so we didn’t get much sleep, this is not a place for people who want some tranquility."
Reviewed on 9 Sept 2026
Hostel Santa Monaca
"No"
Reviewed on 30 Jul 2026
Where to stay in Santo Spirito
Historic Centre of Florence
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza di Santa Maria Novella and Via de' Calzaiuoli are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.
Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.
