Santo Spirito Travel Guide

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A historic church with a dome and bell tower, surrounded by trees and a fountain in a public square.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
See properties

Things to do

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Reserved Entry Florence Duomo: Express Guided Tour

ąøæ867
per adult
80% of travellers recommend
Reserved Entry Florence Duomo: Express Guided Tour
Florence: Reserved Entrance Ticket to the Medici Chapel

Florence: Reserved Entrance Ticket to the Medici Chapel

ąøæ675
per adult
Florence: Reserved Entrance Ticket to the Medici Chapel
Michaelangelo's David

Accademia timed-entry Ticket with App Guide

ąøæ1,481
per adult
90% of travellers recommend
Accademia timed-entry Ticket with App Guide
City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

ąøæ1,103
per adult
74% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Admission Ticket to Franco Zeffirelli Museum

Florence: Admission Ticket to Franco Zeffirelli Museum

ąøæ647
per adult
Florence: Admission Ticket to Franco Zeffirelli Museum
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

ąøæ4,944
per adult
98% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
See all activities in Florence

Top hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
The price is ąøæ4,896 per night from 4 Nov to 5 Nov
ąøæ4,896
ąøæ5,912 total
4 Nov - 5 Nov
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free Wi-Fi and room service. Our guests praise the breakfast and the helpful staff in their reviews. Popular ...
9.8/10 Exceptional! (745 reviews)
"Hotel Horto Convento provided a wonderful experience and allowed me to fully rest and recharge during my travels through Italy. The hotel itself is incredibly comfortable and remarkably quiet, offering a peaceful retreat. The location is excellentā€”it is an easy walk to downtown Florence, and there ..."

Reviewed on 20 Oct 2026

Hotel Horto Convento
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
The price is ąøæ2,368 per night from 16 Nov to 17 Nov
ąøæ2,368
ąøæ2,906 total
16 Nov - 17 Nov
includes taxes & fees
Stay at this hostel in Florence. Enjoy free Wi-Fi, daily housekeeping and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Piazza del ...
Hostel Santa Monaca
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
The price is ąøæ2,829 per night from 8 Nov to 9 Nov
ąøæ2,829
ąøæ3,639 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this residence in Florence. Enjoy free Wi-Fi, valet parking (surcharge) and daily housekeeping. Popular attractions Ponte Vecchio and Piazza del Duomo ...
La Torre Del Cestello
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is ąøæ3,975 per night from 10 Nov to 11 Nov
ąøæ3,975
ąøæ4,900 total
10 Nov - 11 Nov
includes taxes & fees
Stay at this residence in Florence. Enjoy free Wi-Fi, concierge services and premium bedding. Our guests praise the helpful staff in their reviews. Popular attractions ...
Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
The price is ąøæ2,865 per night from 11 Nov to 12 Nov
ąøæ2,865
ąøæ3,679 total
11 Nov - 12 Nov
includes taxes & fees
Stay at this boutique hotel in Florence. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff in their reviews. Popular ...
UNA Hotels Vittoria Firenze
Hotel Firenze 2000

Hotel Firenze 2000

2 out of 5
Viale Raffaello Sanzio, 16 Florence FI
The price is ąøæ3,340 per night from 21 Oct to 22 Oct
ąøæ3,340
ąøæ4,013 total
21 Oct - 22 Oct
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free Wi-Fi and parking (surcharge). Popular attractions Ponte Vecchio and Piazza del Duomo are located ...
Hotel Firenze 2000
See all 538 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Florence.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A grand cathedral with intricate architectural details, including statues and ornate decorations.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito Travel Guide