Santo Spirito Travel Guide

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A historic church with a dome and bell tower, surrounded by trees and a fountain in a public square.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
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Things to do

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Reserved Entry Florence Duomo: Express Guided Tour

ąøæ867
per adult
80% of travellers recommend
Reserved Entry Florence Duomo: Express Guided Tour
Florence: Reserved Entrance Ticket to the Medici Chapel

Florence: Reserved Entrance Ticket to the Medici Chapel

ąøæ675
per adult
Florence: Reserved Entrance Ticket to the Medici Chapel
Michaelangelo's David

Accademia timed-entry Ticket with App Guide

ąøæ1,481
per adult
90% of travellers recommend
Accademia timed-entry Ticket with App Guide
City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

ąøæ1,103
per adult
74% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Admission Ticket to Franco Zeffirelli Museum

Florence: Admission Ticket to Franco Zeffirelli Museum

ąøæ647
per adult
Florence: Admission Ticket to Franco Zeffirelli Museum
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

ąøæ4,944
per adult
98% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
See all activities in Florence

Top hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundable
The price is ąøæ4,912 per night from 3 Nov to 4 Nov
ąøæ4,912
ąøæ5,931 total
3 Nov - 4 Nov
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free Wi-Fi and room service. Our guests praise the breakfast and the helpful staff in their reviews. Popular ...
Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
The price is ąøæ4,136 per night from 8 Nov to 9 Nov
ąøæ4,136
ąøæ5,077 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this residence in Florence. Enjoy free Wi-Fi, valet parking (surcharge) and daily housekeeping. Popular attractions Ponte Vecchio and Piazza del Duomo ...
9/10 Wonderful! (342 reviews)
"The location of the hotel was amazing and central with everything within walking distance. The checkin was smooth and the receptionist was warm. In terms of value for money, we thought the price was higher for the quality of the rooms. The hotel has a nice homely feel though I believe the showers ..."

Reviewed on 8 Oct 2026

La Torre Del Cestello
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
The price is ąøæ2,372 per night from 5 Nov to 6 Nov
ąøæ2,372
ąøæ2,911 total
5 Nov - 6 Nov
includes taxes & fees
Stay at this hostel in Florence. Enjoy free Wi-Fi, daily housekeeping and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Piazza del ...
8/10 Very good! (65 reviews)
"No"

Reviewed on 30 Jul 2026

Hostel Santa Monaca
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is ąøæ3,982 per night from 2 Nov to 3 Nov
ąøæ3,982
ąøæ4,909 total
2 Nov - 3 Nov
includes taxes & fees
Stay at this residence in Florence. Enjoy free Wi-Fi, concierge services and premium bedding. Our guests praise the helpful staff in their reviews. Popular attractions ...
9.2/10 Wonderful! (1,188 reviews)
"Great place. Easy to navigate to and from. Quiet, yet close to everything."

Reviewed on 7 Oct 2026

Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
The price is ąøæ3,302 per night from 8 Nov to 9 Nov
ąøæ3,302
ąøæ4,161 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this boutique hotel in Florence. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff in their reviews. Popular ...
8.4/10 Very good! (1,002 reviews)
"The entrance, the building, the lobby looked very well and promising. Room was small but ok. The shower was terrible, poor mainteined. Room decoration looked agressive. Breakfast was great. Location little far from downtown"

Reviewed on 6 Sept 2026

UNA Hotels Vittoria Firenze
Hotel Firenze 2000

Hotel Firenze 2000

2 out of 5
Viale Raffaello Sanzio, 16 Florence FI
The price is ąøæ4,565 per night from 8 Nov to 9 Nov
ąøæ4,565
ąøæ5,361 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free Wi-Fi and parking (surcharge). Popular attractions Ponte Vecchio and Piazza del Duomo are located ...
7.2/10 Good! (208 reviews)
"Me gusto la ubicaciĆ³n, estamos lo suficientemente cerca de Florencia sin estar en el centro, pero tampoco tan lejos. La habitaciĆ³n no era como en las fotos, a pesar de que la habitaciĆ³n se encontraba muy limpia, los edredones y las sabanas eran viejas, al igual que el TV, aunque todo cumpliĆ³ su funciĆ³n. ..."

Reviewed on 8 Oct 2026

Hotel Firenze 2000
See all 539 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Florence.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A grand cathedral with intricate architectural details, including statues and ornate decorations.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito Travel Guide