Santo Spirito Travel Guide
Florence





Visit Santo Spirito
Stay near popular Santo Spirito attractions
Things to do

Florence: Reserved Entrance Ticket to the Medici Chapel

City Sightseeing Florence Hop-on Hop-off Bus Tour

Accademia timed-entry Ticket with App Guide

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Florence: Admission Ticket to Franco Zeffirelli Museum

Florence: Pizza & Gelato Masterclass Morning, Afternoon or Evening Delight
Top hotels in Santo Spirito

Hotel Horto Convento

La Torre Del Cestello
"Overall experience with this hotel was ok. Itās my first time in Florence so Iām not sure what other hotels are like. But this one is a lot better than what I had in Milan and cheaper. The room is quite spacious. Bathroom is a bit awkward but itās ok. A lot of the things in the room are very basic ..."
Reviewed on 24 Sept 2026

UNA Hotels Vittoria Firenze
"The entrance, the building, the lobby looked very well and promising. Room was small but ok. The shower was terrible, poor mainteined. Room decoration looked agressive. Breakfast was great. Location little far from downtown"
Reviewed on 6 Sept 2026

Casa Santo Nome di Gesù
"Lovely place to stay in Florence away from the crowds. But quick walk to everything. Staff was lovely and room was perfect. Mattress was firm, to my liking. Private garden was beautiful and the bells to the nearby basilica were the perfect start to the day. We stayed 4 nights. I highly recommend ..."
Reviewed on 24 Sept 2026

Hostel Santa Monaca
"No"
Reviewed on 30 Jul 2026

Palazzo Mannaioni Suites
"Lower your expectations and itās not a bad place to stay, just over priced. Palazzo Mannaioni is not a hotel, itās a āresidenceā. Itās one of the first things they tell you when checking in. This is important because what youāre getting is really more of a 2-3 star air bnb than a 4 star hotel. So ..."
Reviewed on 24 Sept 2026
Where to stay in Santo Spirito

Historic Centre of Florence
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.

Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.























