Santo Spirito Travel Guide
Florence
Visit Santo Spirito
Popular places to visit
Piazza Santo Spirito
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
Porta Romana
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the acclaimed art galleries and stunning cathedral in this vibrant area.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Santo Spirito Basilica
Learn about the local history of Florence when you take a trip to Santo Spirito Basilica. Stroll along the riverfront or visit the churches in this vibrant area.
Piazza del Carmine
You can learn about the history of Florence with a trip to Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.
Santa Maria della Carmine
You can learn about the history of Florence with a visit to Santa Maria della Carmine. Visit the churches and notable monuments in this vibrant area.
Things to do
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence: San Gimignano, Siena, Monteriggioni, Chianti & Lunch with Wine
Florence: Reserved Entrance Ticket to the Medici Chapel
Florence: Reserved Entry Ticket to Bargello Museum
Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia
Uffizi Gallery: Small Group Guided Tour or Reserved Entry Ticket
Top hotels in Santo Spirito
Hotel Horto Convento
Everything looked new and very clean. Great location just outside city center.
Reviewed on 6 Mar 2026
Palazzo Mannaioni Suites
We loved the place. Just be aware that if you come by car you have to park it elsewhere.
Reviewed on 5 Mar 2026
UNA Hotels Vittoria Firenze
Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!
Reviewed on 1 Jan 2026
La Torre Del Cestello
Personal je velmi pratelsky, neni co vytknout. Ubytovani je v super lokalite, kousek od hlavnich památek . Postel velmi pohodlna, koupelna prostorna .
Reviewed on 25 Feb 2026
Foresteria Valdese di Firenze - Casa per Ferie
Room was very dated, old and cold. Shower seemed particularly dirty and the water was cold. Of the 9 hotels we have stayed in on our travels thus far this was the only 3 star that on this site rated 4.4. Good location. Lovely staff. Wouldn’t stay again.
Reviewed on 2 Jan 2026
Casa Santo Nome di Gesù
Pretty neat place. Run by nuns. Great building. Friendly staff Breakfast included. Rooms simple clean. Beautiful location. Would definitely go back.
Reviewed on 28 Jan 2026
Other neighbourhoods around Santo Spirito
San Frediano
San Frediano is known for its stunning river views, and you can plan a trip to Piazza Santo Spirito and Boboli Gardens while you're in town.
Oltrarno
Oltrarno is a destination visitors seek out for its fascinating museums, picturesque gardens and beautiful river views. You might also want to check out attractions like Pitti Palace or Pitti Vintage while you're exploring the neighbourhood.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
San Giovanni
If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing.
Historic Centre of Florence
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza di Santa Maria Novella and Via de' Calzaiuoli are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Piazza di Santa Maria Novella while you're exploring the neighbourhood.
