Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿4,165 per night from 12 Jul to 13 Jul
฿4,165
฿4,871 total
12 Jul - 13 Jul
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
8.2/10 Very good! (2,023 reviews)
"Every thing good"

Reviewed on 11 Jul 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ฿5,161 per night from 20 Jul to 21 Jul
฿5,161
฿7,446 total
20 Jul - 21 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,565 reviews)
"Enjoyed the stay breakfast was excellent loved it. Great variety. Hotel was great location. Staff helpful..love our stay. Wished they would have a dinner in hotel instead of just snacks. We showed up after a day out touring and hungry didnt really want to go out to eat chilli night.. but had too ..."

Reviewed on 11 Jul 2026

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ฿5,718 per night from 10 Aug to 11 Aug
฿5,718
฿6,730 total
10 Aug - 11 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,305 reviews)
"Older hotel but very clean and staff were great! The patio doors were "amazing " for keeping the street noise down."

Reviewed on 11 Jul 2026

Handlery Union Square Hotel
Hotel Zoe Fisherman's Wharf

Hotel Zoe Fisherman's Wharf

4 out of 5
425 North Point San Francisco CA
Fully refundableReserve now, pay when you stay
The price is ฿5,359 per night from 4 Aug to 5 Aug
฿5,359
฿7,744 total
4 Aug - 5 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful ...
9.2/10 Wonderful! (2,036 reviews)
"Excellent"

Reviewed on 11 Jul 2026

Hotel Zoe Fisherman's Wharf
Fairmont San Francisco

Fairmont San Francisco

5 out of 5
950 Mason Street Atop Nob Hill San Francisco CA
The price is ฿8,490 per night from 27 Jul to 28 Jul
฿8,490
฿11,755 total
27 Jul - 28 Jul
includes taxes & fees
Stay at this luxury hotel in San Francisco. Enjoy a full-service spa, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff in their reviews. ...
9/10 Wonderful! (1,554 reviews)
"The toilet in the room kept running all night"

Reviewed on 10 Jul 2026

Fairmont San Francisco
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ฿5,158 per night from 27 Jul to 28 Jul
฿5,158
฿6,071 total
27 Jul - 28 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
9/10 Wonderful! (5,989 reviews)
"Pool closes at 9pm, no roof top access after that. Would have enjoyed sitting outside on the rooftop. No microwave in the room. Room was clean and very comfortable."

Reviewed on 11 Jul 2026

Holiday Inn Golden Gateway by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.



Downtown South San Francisco Travel Guide