What's it like in Downtown South San Francisco?

You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.

What's a favourite place to stay in Downtown South San Francisco?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.

How many hotels should I expect to find in the Downtown South San Francisco area?

When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 10 Expedia hotels and other accommodation options in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.

What can I see and do in this South San Francisco neighbourhood?

South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.

The Best Hotels in Downtown South San Francisco, San Francisco - 2026 Updated Prices

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Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

Downtown South San Francisco

Denis

฿5,048 total

includes taxes & fees

23 Aug - 24 Aug

2. Airport Inn

Downtown South San Francisco

Ernest

฿4,444 total

includes taxes & fees

13 Aug - 14 Aug

Premium bedding, pillow-top beds, in-room safe, desk

3. Inn By The SFO

Downtown South San Francisco

Marco

฿3,419 total

includes taxes & fees

1 Sept - 2 Sept

Deluxe Room | 1 bedroom, desk, laptop workspace, iron/ironing board

4. Miller Apartments

Downtown South San Francisco

Lina

฿4,691 total

includes taxes & fees

22 Aug - 23 Aug

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

The East Side, 1.4 km from Downtown South San Francisco

Alain

฿5,686 total

includes taxes & fees

7 Sept - 8 Sept

6. Home2 Suites by Hilton San Francisco Airport North

The East Side, 1.5 km from Downtown South San Francisco

Shaobiao

฿4,593 total

includes taxes & fees

6 Sept - 7 Sept

7. Best Western Plus Grosvenor Airport Hotel

1.8 km from Downtown South San Francisco

Luz

฿3,977 total

includes taxes & fees

30 Aug - 31 Aug

8. DoubleTree by Hilton San Francisco South Airport Blvd

1.5 km from Downtown South San Francisco

Ashley

฿5,070 total

includes taxes & fees

6 Sept - 7 Sept

Business Room, 1 King Bed | Desk, blackout curtains, iron/ironing board, free WiFi

9. Hotel Nova SFO

1.9 km from Downtown South San Francisco

Aarzu

฿4,854 total

includes taxes & fees

14 Aug - 15 Aug

10. Sonesta Select San Francisco Airport Oyster Point Waterfront

Oyster Point, 2.2 km from Downtown South San Francisco

Renato

฿4,511 total

includes taxes & fees

23 Aug - 24 Aug

11. Hotel Aura SFO

4.4 km from Downtown South San Francisco

Stanley

฿4,521 total

includes taxes & fees

24 Aug - 25 Aug

12. Aloft by Marriott San Francisco Airport

6.9 km from Downtown South San Francisco

Jeffrey

฿4,817 total

includes taxes & fees

30 Aug - 31 Aug

Hypo-allergenic bedding, pillow-top beds, laptop workspace

13. The Atrium Hotel

3 km from Downtown South San Francisco

SOHAIL

฿4,826 total

includes taxes & fees

23 Aug - 24 Aug

Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, iron/ironing board

14. Hotel Skye SFO

3.9 km from Downtown South San Francisco

Jaspreet

฿4,449 total

includes taxes & fees

23 Aug - 24 Aug

15. Comfort Inn and Suites San Francisco Airport North

The East Side, 1.1 km from Downtown South San Francisco

฿3,880 total

includes taxes & fees

6 Sept - 7 Sept

16. Hotel Aluxor SFO

3.7 km from Downtown South San Francisco

Christina

฿3,886 total

includes taxes & fees

23 Aug - 24 Aug

17. La Quinta Inn & Suites by Wyndham San Francisco Airport West

5.4 km from Downtown South San Francisco

Colleen

฿4,808 total

includes taxes & fees

7 Sept - 8 Sept

18. Bay Landing San Francisco Airport Hotel

7.9 km from Downtown South San Francisco

Satveer

฿5,627 total

includes taxes & fees

22 Aug - 23 Aug

19. DoubleTree by Hilton San Francisco Airport North Bayfront

3.1 km from Downtown South San Francisco

Robert

฿3,799 total

includes taxes & fees

6 Sept - 7 Sept

20. The Millwood - A Boutique Hotel

5.4 km from Downtown South San Francisco

Robert

฿5,830 total

includes taxes & fees

7 Sept - 8 Sept

View all properties

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

A street with shops, including a crystal shop and a crepes cafe.

Fisherman's Wharf

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

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A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Fashion puts on its finest face in one of the country’s largest shopping plazas.

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A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

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A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

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A street lined with historic buildings, parked cars, and a clear blue sky.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

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Top Downtown South San Francisco Hotel Reviews

Hilton San Francisco Union Square

10/10 Excellent

"Clean with great view"

Chancellor Hotel on Union Square

10/10 Excellent

"This is a hidden gem! We were somewhat leery booking this property because the price was $150 for the night. What we experienced was a great boutique style hotel. The room was smaller but had a large walk in closet, which you don’t see in hotels. This allowed us to put luggage in there and made the room feel bigger. Highly recommend staying here!"

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"All staff were friendly & helpful. While booking reservation I had requested adjoining rooms. Our flight arrival was early AM so I inquired if early check-in was possible & the additional charge. A wonderful benefit provided is the hotel securely storing your luggage until check in. We were able to go exploring without dragging our luggage with us. Front desk staff always very friendly & helpful. We were happily able to check in a bit earlier than 1500 thanks to desk staff!! Breakfast was great! I love that it’s available especially with growing boys. Impressive how well organized & quickly they dealt with such a large groups of people. Loved the seating by the fire. Unfortunately I wish the seating could be arranged differently. Many times 1 person would take up the entire couch- making it difficult for families. Rooms were very clean & well stocked. Proximity to Fisherman’s Wharf a plus. I would highly recommend & would stay there again!"

Search Hotels in Downtown South San Francisco, San Francisco

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Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

3. Inn By The SFO

4. Miller Apartments

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

6. Home2 Suites by Hilton San Francisco Airport North

7. Best Western Plus Grosvenor Airport Hotel

8. DoubleTree by Hilton San Francisco South Airport Blvd

9. Hotel Nova SFO

10. Sonesta Select San Francisco Airport Oyster Point Waterfront

11. Hotel Aura SFO

12. Aloft by Marriott San Francisco Airport

13. The Atrium Hotel

14. Hotel Skye SFO

15. Comfort Inn and Suites San Francisco Airport North

16. Hotel Aluxor SFO

17. La Quinta Inn & Suites by Wyndham San Francisco Airport West

18. Bay Landing San Francisco Airport Hotel

19. DoubleTree by Hilton San Francisco Airport North Bayfront

20. The Millwood - A Boutique Hotel

Where to stay in Downtown South San Francisco

Fisherman's Wharf

Union Square

Downtown San Francisco

South of Market

Nob Hill

Top Downtown South San Francisco Hotel Reviews

Hilton San Francisco Union Square

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