Search Hotels in Downtown South San Francisco, San Francisco

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5 Jan - 6 Jan
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6 Jan - 7 Jan
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9 Jan - 11 Jan
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16 Jan - 18 Jan

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Our top choices for Downtown South San Francisco hotels

Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very good, (2025)
"Clean room, staff were friendly, breakfast was good, parking was good, overall we're satisfied!"
Canada
Edna
The price is ฿3,168
฿3,721 total
includes taxes & fees
23 Jan - 24 Jan
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Interior detail
Airport Inn

Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
8.8 out of 10, Excellent, (972)
"Very clean room, friendly staff and secure parking."
United States
Christopher
The price is ฿3,100
฿3,636 total
includes taxes & fees
9 Jan - 10 Jan
Airport Inn
Lobby
Inn By The SFO

Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.8 out of 10, Good, (1000)
"Excellent property!!! I would definitely recommend!!! Great stay!!! "
United States
David
Inn By The SFO
Fridge, microwave, coffee/tea maker, dining tables
Miller Apartments

Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.4 out of 10, Good, (15)
"Own bedroom was quiet and tidy, shared bathroom clean and tidy, good communication "
Australia
Kasey
The price is ฿2,349
฿5,109 total
includes taxes & fees
9 Jan - 10 Jan
Miller Apartments
Lobby sitting area
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (7259)
"Great place to stay!"
United States
Isaiah
The price is ฿3,262
฿5,138 total
includes taxes & fees
25 Jan - 26 Jan
Hotel Riu Plaza Fisherman's Wharf
Front of property – evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2239)
"We loved our stay! "
United States
Christine
The price is ฿3,306
฿3,891 total
includes taxes & fees
8 Jan - 9 Jan
Hilton San Francisco Financial District
Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (3852)
"Great location and great staff"
United Kingdom
Stephanie
The price is ฿3,993
฿6,146 total
includes taxes & fees
8 Jan - 9 Jan
Hotel Caza Fisherman's Wharf
Exterior
Aloft San Francisco Airport

Aloft San Francisco Airport

Aloft San Francisco Airport
3.0 star property
6.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2252)
"Room was clean and checkin staff was very friendly!"
United States
Youngjin
The price is ฿3,856
฿4,432 total
includes taxes & fees
7 Jan - 8 Jan
Aloft San Francisco Airport
Games room
Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
16.8 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2369)
"Great place to stay with kids. Walkable to most everything and seemed very safe "
United States
Amy
The price is ฿3,869
฿5,852 total
includes taxes & fees
7 Jan - 8 Jan
Hotel Zephyr San Francisco
Interior entrance
Hotel Zoe Fisherman's Wharf

Hotel Zoe Fisherman's Wharf

Hotel Zoe Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (1660)
"Great location, service, and rooms!"
United States
Joyce
The price is ฿3,462
฿5,412 total
includes taxes & fees
7 Jan - 8 Jan
Hotel Zoe Fisherman's Wharf
Exterior
The Westin San Francisco Airport

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2025)
"Comfortable room, welcome glass of wine, easy shuttle to and from airport, friendly staff."
United States
Carole
The price is ฿3,223
฿4,621 total
includes taxes & fees
9 Jan - 10 Jan
The Westin San Francisco Airport
Outdoor pool, open 9:00 AM to 7:00 PM, pool loungers
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
14.8 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (5112)
"Great stay!"
United States
Carlos Emiro
The price is ฿3,805
฿4,479 total
includes taxes & fees
7 Jan - 8 Jan
Holiday Inn Golden Gateway by IHG
Free daily buffet breakfast
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
16.6 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2264)
"Awesome place to stay"
United States
Mark Anthony
The price is ฿3,846
฿5,551 total
includes taxes & fees
15 Jan - 16 Jan
Holiday Inn Express and Suites Fisherman's Wharf by IHG
American cuisine
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront
4.0 star property
9.9 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2835)
"Great place "
United States
Niharika
The price is ฿3,313
฿3,766 total
includes taxes & fees
16 Jan - 17 Jan
Hilton San Francisco Airport Bayfront
Exterior
Handlery Union Square Hotel

Handlery Union Square Hotel

Handlery Union Square Hotel
3.5 star property
14.5 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2829)
"Ok place to stay"
United States
Jovana
The price is ฿23,619
฿27,799 total
includes taxes & fees
5 Feb - 6 Feb
Handlery Union Square Hotel
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
14.7 km from Downtown South San Francisco
9.4 out of 10, Exceptional, (3128)
"Location, ease of check in, great staff"
United States
Margaret
The price is ฿2,388
฿2,821 total
includes taxes & fees
7 Jan - 8 Jan
Chancellor Hotel on Union Square
Exterior
King George Hotel

King George Hotel

King George Hotel
3.0 star property
14.5 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2105)
"The staff were all friendly and courteous, the room and bathroom were very clean, the beds were comfortable and a very good location."
United States
Jamie
The price is ฿2,639
฿3,579 total
includes taxes & fees
7 Jan - 8 Jan
King George Hotel
Breakfast and dinner served
DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront
4.0 star property
3.1 km from Downtown South San Francisco
8.0 out of 10, Very good, (1359)
"It was a comfortable stay there. "
United States
Asif
The price is ฿2,542
฿3,008 total
includes taxes & fees
9 Jan - 10 Jan
DoubleTree by Hilton San Francisco Airport North Bayfront
Corner Queen Room | Hypo-allergenic bedding, in-room safe, laptop workspace
YOTEL San Francisco

YOTEL San Francisco

YOTEL San Francisco
3.0 star property
13.8 km from Downtown South San Francisco
8.2 out of 10, Very good, (1009)
"Great place to stay. This is my second time here and I’m never disappointed!"
United States
Adan
The price is ฿2,385
฿4,105 total
includes taxes & fees
8 Jan - 9 Jan
YOTEL San Francisco
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2872)
"Clean room, friendly staff and good location"
United States
Jose Eduardo
The price is ฿3,283
฿3,864 total
includes taxes & fees
23 Jan - 24 Jan
Club Quarters Hotel in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
Union Square featuring a skyscraper and a city

Union Square

Fashion puts on its finest face in one of the country’s largest shopping plazas.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

Fisherman\'s Wharf featuring a bay or harbour

Fisherman's Wharf

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

South of Market which includes skyline, a park and cbd

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill showing street scenes and a city

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Downtown South San Francisco Hotel Reviews

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.
What's a favourite place to stay in Downtown South San Francisco?
Based on Expedia customer reviews, La Quinta Inn & Suites by Wyndham San Francisco Airport N is a highly ranked property in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool. Another favourite option in the neighbourhood is Airport Inn.
How many hotels should I expect to find in the Downtown South San Francisco area?
When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 14 Expedia hotels and other accommodation options in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.
What can I see and do in this South San Francisco neighbourhood?
See's Candies, Cinemark Century at Tanforan and K1 Speed are just a few of the places to visit in and around Downtown South San Francisco. K1 Speed San Francisco and The Shops at Tanforan are also worth a visit when you're out sightseeing in South San Francisco.