Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do

Go City: San Francisco All-Inclusive Pass with 25+ Attractions

Go City: San Francisco All-Inclusive Pass with 30+ Attractions

฿3,612
per adult
88% of travellers recommend
Go City: San Francisco All-Inclusive Pass with 30+ Attractions
California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

฿1,622
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
Golden Gate Bridge at night

San Francisco Night Tour

฿1,754
per adult
78% of travellers recommend
San Francisco Night Tour
1 Day Hop-On Hop-Off Tour

San Francisco 1 Day Hop-On Hop-Off City Tour

฿2,316
per adult
92% of travellers recommend
San Francisco 1 Day Hop-On Hop-Off City Tour
San Francisco Hop-On Hop-Off Tours

San Francisco Hop-On Hop-Off Tours PLUS Night Tour

฿2,316
per adult
72% of travellers recommend
San Francisco Hop-On Hop-Off Tours PLUS Night Tour
#1 San Francisco Pub Crawl & Clubbing Experience

San Francisco Pub Crawl & Clubbing Experience

฿900
per adult
San Francisco Pub Crawl & Clubbing Experience
See all activities in San Francisco

Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿4,282 per night from 1 Sept to 2 Sept
฿4,282
฿5,005 total
1 Sept - 2 Sept
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ฿5,043 per night from 31 Aug to 1 Sept
฿5,043
฿5,936 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ฿4,364 per night from 31 Aug to 1 Sept
฿4,364
฿6,503 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,616 reviews)
"Comfortable. Convenient location. Good breakfast. Adequate workout facility. Hot tub works have been nice since it was too cold to use pool."

Reviewed on 15 Aug 2026

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ฿5,450 per night from 31 Aug to 1 Sept
฿5,450
฿6,414 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
Handlery Union Square Hotel
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
The price is ฿5,133 per night from 7 Sept to 8 Sept
฿5,133
฿6,041 total
7 Sept - 8 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge) and a 24-hour health club. Our guests praise the helpful staff ...
Hilton San Francisco Union Square
Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

4 out of 5
55 Cyril Magnin St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is ฿5,048 per night from 6 Sept to 7 Sept
฿5,048
฿5,942 total
6 Sept - 7 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful ...
8.8/10 Excellent! (1,600 reviews)
"Very modern, sleek hotel in the heart of Union Square and just steps away from BART!"

Reviewed on 15 Aug 2026

Parc 55 San Francisco - A Hilton Hotel
See all 4,212 properties in Downtown South San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
A street with shops, including a crystal shop and a crepes cafe.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

A street lined with historic buildings, parked cars, and a clear blue sky.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.

Downtown South San Francisco Travel Guide