Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿4,185 per night from 1 Sept to 2 Sept
฿4,185
฿4,893 total
1 Sept - 2 Sept
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ฿5,038 per night from 23 Aug to 24 Aug
฿5,038
฿5,929 total
23 Aug - 24 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ฿4,355 per night from 31 Aug to 1 Sept
฿4,355
฿6,491 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,632 reviews)
"Clean room; breakfast was great and we got to check in a couple hours early!!"

Reviewed on 18 Aug 2026

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ฿5,427 per night from 1 Sept to 2 Sept
฿5,427
฿6,387 total
1 Sept - 2 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,447 reviews)
"Lovely hotel. Staff very helpful. We didn’t use the pool as too busy sightseeing but was told it was heated and open 8am to 8pm. Room was clean and had a good size bed with tv. Shower and bathroom was adequate for what I needed. Would stay here again if in San Francisco."

Reviewed on 18 Aug 2026

Handlery Union Square Hotel
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
The price is ฿5,028 per night from 3 Sept to 4 Sept
฿5,028
฿5,917 total
3 Sept - 4 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge) and a 24-hour health club. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,570 reviews)
"The hotel is nice and clean, the area around is not really safe, but one can avoid walking in Tenderloin in the evening and rather hit directly to the safer part of the hotel area. I found the service average, which is maybe not what people would expext from a hotel chain such as Hilton. Nevertheless, ..."

Reviewed on 17 Aug 2026

Hilton San Francisco Union Square
Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

4 out of 5
55 Cyril Magnin St San Francisco CA
The price is ฿5,027 per night from 6 Sept to 7 Sept
฿5,027
฿5,917 total
6 Sept - 7 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy 2 restaurants, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful ...
8.8/10 Excellent! (1,619 reviews)
"Assss"

Reviewed on 18 Aug 2026

Parc 55 San Francisco - A Hilton Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.



Downtown South San Francisco Travel Guide