Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do

California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

฿1,636
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
Go City: San Francisco All-Inclusive Pass with 25+ Attractions

Go City: San Francisco All-Inclusive Pass with 30+ Attractions

฿3,275
per adult
88% of travellers recommend
Go City: San Francisco All-Inclusive Pass with 30+ Attractions
Golden Gate Bridge at night

San Francisco Night Tour

฿1,592
per adult
76% of travellers recommend
San Francisco Night Tour
1 Day Hop-On Hop-Off Tour

San Francisco 1 Day Hop-On Hop-Off City Tour

฿2,337
per adult
92% of travellers recommend
San Francisco 1 Day Hop-On Hop-Off City Tour
San Francisco: Movie Filming Locations Bus Tour

San Francisco: Movie Filming Locations Bus Tour

฿2,638
per adult
96% of travellers recommend
San Francisco: Movie Filming Locations Bus Tour
San Francisco Hop-On Hop-Off Tours

San Francisco 1-Day and 2-Day Hop-On Hop-Off Tours + Night Tour

฿2,337
per adult
72% of travellers recommend
San Francisco 1-Day and 2-Day Hop-On Hop-Off Tours + Night Tour
See all activities in San Francisco

Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿4,543 per night from 26 Oct to 27 Oct
฿4,543
฿5,306 total
26 Oct - 27 Oct
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ฿4,833 per night from 8 Nov to 9 Nov
฿4,833
฿5,688 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
9/10 Wonderful! (6,386 reviews)
"Prime location. Trolly stops nearby. Awesome views of the city and lots of food places to eat and Whole Foods across the street."

Reviewed on 8 Oct 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ฿4,117 per night from 3 Nov to 4 Nov
฿4,117
฿6,230 total
3 Nov - 4 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,709 reviews)
"Its a grate place and location are very good for the diferent activity"

Reviewed on 8 Oct 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is ฿3,007 per night from 8 Nov to 9 Nov
฿3,007
฿3,539 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
Hilton San Francisco Financial District
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
The price is ฿4,934 per night from 6 Nov to 7 Nov
฿4,934
฿5,807 total
6 Nov - 7 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge) and a 24-hour health club. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,769 reviews)
"Cheap towels and only one set per room."

Reviewed on 8 Oct 2026

Hilton San Francisco Union Square
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
The price is ฿7,362 per night from 7 Nov to 8 Nov
฿7,362
฿10,210 total
7 Nov - 8 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
Hyatt Regency San Francisco
See all 4,164 properties in Downtown South San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

A city street with tall buildings, flags, and cars.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to Chase Center – discover South of Market, a destination also famous for its shopping.

A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.

Downtown South San Francisco Travel Guide