Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿3,905 per night from 20 Sept to 21 Sept
฿3,905
฿4,572 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
8.2/10 Very good! (2,126 reviews)
"The only issue we had we got the mobility room first and the bathroom smelled horrible, like a lot like pee, kind of how it smells sometimes in downtowns where homeless smell, they changed our room with no problem and the next one was perfectly fine, staff was really nice and helpful, Lucerito checked ..."

Reviewed on 14 Sept 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ฿5,309 per night from 20 Sept to 21 Sept
฿5,309
฿6,249 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
9/10 Wonderful! (6,304 reviews)
"I had a great experience and would recommend."

Reviewed on 14 Sept 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ฿5,490 per night from 18 Sept to 19 Sept
฿5,490
฿7,824 total
18 Sept - 19 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,689 reviews)
"Great Location - Amazing Breakfast"

Reviewed on 14 Sept 2026

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ฿5,428 per night from 20 Sept to 21 Sept
฿5,428
฿6,389 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,547 reviews)
"Great rooms, great price!"

Reviewed on 14 Sept 2026

Handlery Union Square Hotel
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is ฿4,038 per night from 20 Sept to 21 Sept
฿4,038
฿4,753 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.8/10 Excellent! (3,218 reviews)
"Our room was clean and cozy, with an amazing view. The concierge Pacifico is absolutely amazing. We enjoyed our stay. The location cannot be beat either."

Reviewed on 14 Sept 2026

Hilton San Francisco Financial District
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

3.5 out of 5
433 Powell St San Francisco CA
The price is ฿4,733 per night from 18 Sept to 19 Sept
฿4,733
฿5,578 total
18 Sept - 19 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, a 24-hour front desk and daily housekeeping. Our guests praise the helpful staff and ...
9.4/10 Exceptional! (3,453 reviews)
"Excelente"

Reviewed on 13 Sept 2026

Chancellor Hotel on Union Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.



Downtown South San Francisco Travel Guide