Medical Center District Travel Guide

San Antonio

River walk in San Antonio
River walk in San Antonio
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Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is ฿2,807 per night from 15 Mar to 16 Mar
฿2,807
฿3,317 total
15 Mar - 16 Mar
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is ฿3,159 per night from 27 Mar to 28 Mar
฿3,159
฿3,754 total
27 Mar - 28 Mar
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,000 reviews)
Rooms were nice and clean! No issues for the orice i paid

Reviewed on 11 Mar 2026

San Antonio Marriott Northwest Medical Center
Park Inn by Radisson

Park Inn by Radisson

2 out of 5
7500 Louis Pasteur Drive San Antonio TX
The price is ฿2,032 per night from 25 Mar to 26 Mar
฿2,032
฿2,373 total
25 Mar - 26 Mar
includes taxes & fees
Stay at this motel in San Antonio. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff in their reviews. Popular attractions ...
7.2/10 Good! (1,000 reviews)
Nothing out of the ordinary but in a good way.

Reviewed on 28 Feb 2026

Park Inn by Radisson
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham San Antonio TX
The price is ฿3,030 per night from 7 Apr to 8 Apr
฿3,030
฿3,582 total
7 Apr - 8 Apr
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and an outdoor pool. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (2,020 reviews)
For some reason, they did not do housekeeping in their rooms, unless you request it. So I requested it and the only towels and they said that since I have only been there for three nights at that point, it was only a light housekeeping service.. to me this is unacceptable…. I also have changed from ...

Reviewed on 11 Mar 2026

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,377 reviews)
We enjoyed our stay

Reviewed on 12 Mar 2026

Riverwalk Plaza
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
The price is ฿3,937 per night from 31 Mar to 1 Apr
฿3,937
฿4,653 total
31 Mar - 1 Apr
includes taxes & fees
Stay at this historic hotel in San Antonio. Enjoy free Wi-Fi, valet parking (surcharge) and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,588 reviews)
Not worth the stay, hotel needs an upgrade, tub is discolored and needs caulking all around. Cleanliness is great and staff are nice! Most likely won’t be staying there again. No amenities to offer guest.

Reviewed on 11 Mar 2026

Crockett Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Dub Farris Athletic Complex are top sights worth seeing.

Northwest Side
Sam's Burger Joint

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or The DoSeum while you're exploring the area.

Midtown
Historic architecture Spanish San Antonio Texas Mission San Jose on a cloudy day

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
One of the coolest bars in San Antonio. Definitely check it out.

Tobin Hill

Tobin Hill might not have many top sights, but San Antonio Zoo and Aquarium and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
Marion Koogler McNay Art Museum which includes art and interior views as well as an individual male

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown
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Alamo Heights

You'll enjoy the museums and coffee shops in Alamo Heights. You might want to make time for a stop at San Antonio River or Toilet Seat Museum.

Alamo Heights


Medical Center District Travel Guide