Medical Center District Travel Guide

San Antonio

Photo by Linda Cronan

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
The price is ฿2,818 per night from 18 Sept to 19 Sept
฿2,818
per night
18 Sept - 19 Sept
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,938 reviews)
I always choose this hotel!
"Hotel was great as usual, will definitely be back on our next trip. I just wish all the rooms/tvs were updated the same"

Reviewed on 15 Sept 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
The price is ฿2,767 per night from 19 Sept to 20 Sept
฿2,767
per night
19 Sept - 20 Sept
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free local area shuttle and room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,008 reviews)
"It was great"

Reviewed on 15 Sept 2025

San Antonio Marriott Northwest Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
The price is ฿2,863 per night from 28 Sept to 29 Sept
฿2,863
per night
28 Sept - 29 Sept
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,011 reviews)
"Very clean property with great staff. Had no issues at check-in and throughout my stay. Parking is very easy and convenient. I would stay again."

Reviewed on 15 Sept 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
The price is ฿2,831 per night from 26 Sept to 27 Sept
฿2,831
per night
26 Sept - 27 Sept
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,003 reviews)
10 out 10
"Very clean and nice place. Would stay again"

Reviewed on 26 Aug 2025

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the ...
8/10 Very Good! (5,809 reviews)
Cleanliness
"Although clean enough it was very dated and run down which made it look grubby. Info on QR about the menu in restaurant was wrong. Very disjointed building which made it hard to find room at start"

Reviewed on 15 Sept 2025

Riverwalk Plaza
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive, San Antonio, TX
The price is ฿2,985 per night from 23 Sept to 24 Sept
฿2,985
per night
23 Sept - 24 Sept
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and a lazy river. Our guests praise the pool and the helpful staff ...
8.8/10 Excellent! (979 reviews)
"Loved every minute of this place! 3 nights was amazing. Can’t wait to come back"

Reviewed on 10 Sept 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Los Angeles Heights

While Northwest Los Angeles Heights may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Alamo and Alamodome.

Northwest Los Angeles Heights
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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Northwest Side
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by The DoSeum or San Antonio Zoo and Aquarium while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Tobin Hill might not have many top sights, but Alamo and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
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Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Uptown


Medical Center District Travel Guide