Search Luxury Hotels in South America
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on South America Luxury Hotels
Our top choices for South America luxury hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Hotel das Cataratas, A Belmond Hotel, Iguassu FallsFoz do Iguaçu
10.0 out of 10, Exceptional, (1,005 reviews)
- Exclusive park access and stunning Iguazu Falls views unite with full-service spa treatments at this luxurious Belmond retreat.
The price is ฿24,596
฿28,471 total
includes taxes & fees
26 Jul - 27 Jul
9.4 out of 10, Exceptional, (674 reviews)
- Intimate Buenos Aires boutique hotel offers deep soaking tubs, full-service spa treatments, and garden-view fine dining in Recoleta.
The price is ฿7,267
฿7,368 total
23 Jul - 24 Jul
Palacio del Inka, A Luxury Collection Hotel by Marriott
Palacio del Inka, A Luxury Collection Hotel by MarriottCusco Historic Center
9.6 out of 10, Exceptional, (1,004 reviews)
- Opulent Peruvian palace with full-service spa offers historic luxury and pampering treatments in the heart of ancient Cusco.
The price is ฿13,119
฿15,826 total
24 Jul - 25 Jul
9.4 out of 10, Exceptional, (261 reviews)
- Art deco elegance defines this Buenos Aires retreat with pool, sauna, and premium bedding in El Centro.
Hotel Paracas, a Luxury Collection Resort, Paracas
Hotel Paracas, a Luxury Collection Resort, ParacasParacas
9.4 out of 10, Exceptional, (788 reviews)
- Indulge in beachfront luxury at this Paracas resort featuring a full-service spa and 2 ocean pools.
The price is ฿8,735
฿9,608 total
16 Aug - 17 Aug
9.6 out of 10, Exceptional, (1,000 reviews)
- Indulge in 5-star opulence at this Buenos Aires hotel with private hot tubs, poolside service, and a full-service spa.
The price is ฿16,026
฿16,127 total
24 Jul - 25 Jul
9.8 out of 10, Exceptional, (1,003 reviews)
- Historic luxury in the heart of Cusco with an indulgent spa, indoor pool, and five-star service just steps from Plaza de Armas.
The price is ฿12,380
฿14,998 total
20 Aug - 21 Aug
9.6 out of 10, Exceptional, (749 reviews)
- Indulge in spa serenity at this luxury Santiago hotel, where rooftop dining meets city centre elegance.
The price is ฿9,106
฿9,106 total
23 Jul - 24 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top South America Hotel Reviews
Melia Paulista
10/10 Excellent
Explore a world of travel with Expedia
- Aracaju Hotels
- Bogotá Hotels
- Brasília Hotels
- Buenos Aires Hotels
- Caldas Novas Hotels
- Campos do Jordão Hotels
- Gay-Friendly Hotels in Cartagena
- Hotels with Laundry Service in Cartagena
- Cartagena Hotels
- Cusco Hotels
- Brazil Hotels
- Adults Only Resorts & in Colombia
- Sports Hotels in Colombia
- All-Inclusive Hotels in Colombia
- Beach Resorts & in Colombia
- Boutique Hotels in Colombia
- Cheap Hotels in Colombia
- Business Hotels in Colombia
- Casino Hotels in Colombia
- Family-Friendly Hotels in Colombia
- Gay-Friendly Hotels in Colombia
- Golf Hotels in Colombia
- Georgetown Hotels
- Lima Hotels
- Maceió Hotels
- Medellín Hotels
- Medellín Hotels
- Praia Grande Hotels
- Salta Hotels
- Gay-Friendly Hotels in Salvador
- Gay-Friendly Hotels in San Andrés
- San Andrés Hotels
- Gay-Friendly Hotels in Santa Marta
- Yoga Hotels in Santa Marta
- Santa Marta Hotels
- São Luís Hotels
- Visit Bogotá
- Visit Brasília
- Brazil Holidays
- Buenos Aires Holidays
- Visit Buenos Aires
- Visit Cartagena
- Colombia Holidays
- Visit Curitiba
- Visit Florianópolis
- Visit Fortaleza
- Visit Maceió
- Machu Picchu Holidays
- Visit Medellín
- Visit Montevideo
- Rio de Janeiro Holidays
- Visit Tristan da Cunha
- Visit Vina del Mar