Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿4,536 per night from 11 Oct to 12 Oct
฿4,536
฿5,297 total
11 Oct - 12 Oct
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
8.2/10 Very good! (2,142 reviews)
"Interior was really dated. Front desk staff was super friendly. Had a room next to ice machine and will pay more attention to that…someone needed lots of ice at 5:00am which woke us all up. Shuttle is a hassle, especially on the way back to airport since it stops at multiple hotels on the way. Would ..."

Reviewed on 6 Oct 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is ฿5,101 per night from 25 Oct to 26 Oct
฿5,101
฿6,004 total
25 Oct - 26 Oct
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
9/10 Wonderful! (6,387 reviews)
"Property is well located and the amenities on site were very good. Nice bar and decent restaurant. Negative is always parking. Expensive and our vehicle was actually too tall for the garage that is only 5’8”"

Reviewed on 6 Oct 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is ฿4,110 per night from 3 Nov to 4 Nov
฿4,110
฿6,219 total
3 Nov - 4 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is ฿4,651 per night from 1 Nov to 2 Nov
฿4,651
฿5,474 total
1 Nov - 2 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
Hilton San Francisco Financial District
Hilton San Francisco Union Square

Hilton San Francisco Union Square

4 out of 5
333 O'Farrell St. San Francisco CA
The price is ฿4,944 per night from 6 Nov to 7 Nov
฿4,944
฿5,818 total
6 Nov - 7 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy 2 bars/lounges, breakfast (surcharge) and a 24-hour health club. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,763 reviews)
"Enjoyed our stay at Hilton very much. Would recommend it."

Reviewed on 5 Oct 2026

Hilton San Francisco Union Square
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
The price is ฿7,349 per night from 6 Nov to 7 Nov
฿7,349
฿10,192 total
6 Nov - 7 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
Hyatt Regency San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to Chase Center – discover South of Market, a destination also famous for its shopping.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.



Downtown South San Francisco Travel Guide