Downtown South San Francisco Travel Guide

San Francisco

An aerial view of a city with a large stadium, several schools, and a dense residential area.
An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.
A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

Things to do


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is ฿4,245 per night from 27 Jul to 28 Jul
฿4,245
฿4,963 total
27 Jul - 28 Jul
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
8.2/10 Very good! (2,030 reviews)
"Was pretty dope. Good for the price"

Reviewed on 13 Jul 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is ฿5,191 per night from 20 Jul to 21 Jul
฿5,191
฿7,489 total
20 Jul - 21 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,585 reviews)
"The rooms and beds were comfortable and the air conditioning/heating system was efficient and worked great. There were places to gather in the lobby if you are traveling with a group. The hotel is walking distance to many activities and attractions. Breakfast was good but crowded and the wait to ..."

Reviewed on 13 Jul 2026

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is ฿5,752 per night from 21 Jul to 22 Jul
฿5,752
฿6,769 total
21 Jul - 22 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,313 reviews)
"Just plan on paying quite a bit for parking"

Reviewed on 13 Jul 2026

Handlery Union Square Hotel
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
The price is ฿6,664 per night from 17 Jul to 18 Jul
฿6,664
฿9,382 total
17 Jul - 18 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (2,373 reviews)
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Reviewed on 13 Jul 2026

Hyatt Regency San Francisco
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is ฿5,325 per night from 19 Jul to 20 Jul
฿5,325
฿6,267 total
19 Jul - 20 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.8/10 Excellent! (3,002 reviews)
"Location is great"

Reviewed on 13 Jul 2026

Hilton San Francisco Financial District
Fairmont San Francisco

Fairmont San Francisco

5 out of 5
950 Mason Street Atop Nob Hill San Francisco CA
The price is ฿8,372 per night from 19 Jul to 20 Jul
฿8,372
฿11,627 total
19 Jul - 20 Jul
includes taxes & fees
Stay at this luxury hotel in San Francisco. Enjoy a full-service spa, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff in their reviews. ...
9/10 Wonderful! (1,557 reviews)
"Beautiful suites, helpful staff"

Reviewed on 13 Jul 2026

Fairmont San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.



Downtown South San Francisco Travel Guide