Midtown Travel Guide

St. Louis

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.
A sundae with chocolate ice cream and whipped cream.
A cathedral interior with Gothic architecture, including pointed arches and ribbed vaults.
A Gothic-style cathedral with intricate stonework, pointed arches, and statues.
A highway with multiple lanes, vehicles, and a bridge overhead.

Stay near popular Midtown attractions

Things to do


Top hotels in Midtown

Element by Marriott St. Louis Midtown

Element by Marriott St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is ฿4,549 per night from 9 Aug to 10 Aug
฿4,549
฿5,319 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (788 reviews)
"Clean, with very comfortable beds, a great kitchenette (in my room, at least), & a better than average breakfast. Be aware that the “cooked-to-order” breakfast sounds more expansive than it really is; but it’s still better than average."

Reviewed on 24 Jul 2026

Element by Marriott St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is ฿3,976 per night from 9 Aug to 10 Aug
฿3,976
฿4,728 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a 24-hour fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
7.8/10 Good! (1,003 reviews)
"Has to wait and request the room I booked. The hotel smelled like weed."

Reviewed on 24 Jul 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ฿5,125 per night from 31 Jul to 1 Aug
฿5,125
฿6,044 total
31 Jul - 1 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,139 reviews)
"Very friendly and helpful customer service, clean room"

Reviewed on 25 Jul 2026

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,289 per night from 9 Aug to 10 Aug
฿3,289
฿3,840 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
9/10 Wonderful! (3,281 reviews)
"Everything was very good, except that it was quite complicated. The parking was connected to the hotel, but you had to drive up, look for the proper door and you had to pay for the parking with special card. Same with the breakfast, while it was tasteful, it had a system for tips that was not explained ..."

Reviewed on 25 Jul 2026

Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is ฿4,380 per night from 2 Aug to 3 Aug
฿4,380
฿5,602 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (2,210 reviews)
"I booked a hotel room to stay the night at after seeing Hilary Duff's concert on 7/22/2026 (highly recommend seeing her live!), & overall it was a 8 out of 10. The hotel was very nice both inside & outside, the staff was courteous, kind, & helpful, & the shuttle services provided to & from the concert ..."

Reviewed on 25 Jul 2026

Hollywood Casino & Hotel St. Louis
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is ฿3,369 per night from 2 Aug to 3 Aug
฿3,369
฿3,966 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (3,102 reviews)
"The bathroom sink didn’t drain. The keys did not work. They had to let us in the room and the TV did not work."

Reviewed on 25 Jul 2026

Pear Tree Inn St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.



Midtown Travel Guide