Midtown Travel Guide

St. Louis

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.
A sundae with chocolate ice cream and whipped cream.
A cathedral interior with Gothic architecture, including pointed arches and ribbed vaults.
A Gothic-style cathedral with intricate stonework, pointed arches, and statues.
A highway with multiple lanes, vehicles, and a bridge overhead.

Stay near popular Midtown attractions

Things to do


Top hotels in Midtown

Element by Marriott St. Louis Midtown

Element by Marriott St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is ฿4,563 per night from 10 Aug to 11 Aug
฿4,563
฿5,335 total
10 Aug - 11 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (785 reviews)
"The room was so humid that my feet felt wet on the non-carpeted floor. It seemed to be a swamp cooler in the room rather than an air conditioner - insanely loud too. Also, they want $40 for lot parking or $28 plus tip for valet. The alternative is street parking that you have to start paying at 7am ..."

Reviewed on 23 Jul 2026

Element by Marriott St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is ฿3,980 per night from 10 Aug to 11 Aug
฿3,980
฿4,733 total
10 Aug - 11 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a 24-hour fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
7.8/10 Good! (1,000 reviews)
"Clean room; friendly staff; easy parking; decent breakfast"

Reviewed on 20 Jul 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundable
The price is ฿5,141 per night from 31 Jul to 1 Aug
฿5,141
฿6,063 total
31 Jul - 1 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,131 reviews)
"The room was not clean. After walking on the carpet in the room my socks were filthy. The air conditioner in the room was blowing out a warm sticky mist. I had the air on 65 and it didn't cool off the room. I complained to the front desk staff and all they said was there were other guests that have ..."

Reviewed on 23 Jul 2026

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,271 per night from 9 Aug to 10 Aug
฿3,271
฿3,818 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
9/10 Wonderful! (3,268 reviews)
"The best part was the breakfast and shower. We didn’t get to use the pool since we only came in town for one night. Being in hospitality myself as an AGM I was very pleased. The price was decent and also the area. If I ever decide to come visit again I will stay again."

Reviewed on 23 Jul 2026

Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is ฿4,394 per night from 2 Aug to 3 Aug
฿4,394
฿5,620 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
Hollywood Casino & Hotel St. Louis
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is ฿3,380 per night from 2 Aug to 3 Aug
฿3,380
฿3,979 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (3,095 reviews)
"As many travelers mentioned, this was a great hotel. Renovated room was not only the cleanest but also functional -- to say nothing of plenty of hot water for a shower and drainage for the bathroom. Small refrigerator and microwave allows us to take every dinner in the room. But, the real highlight ..."

Reviewed on 23 Jul 2026

Pear Tree Inn St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.



Midtown Travel Guide