What is Midtown like?

Travellers are sure to enjoy a stay in St. Louis's Midtown neighbourhood. Make sure that you visit Chaifetz Arena and Washington Avenue Historic District as part of your Midtown travel plans.

Where is the best place to stay in Midtown?

Based on our traveller data, Element by Marriott St. Louis Midtown is one of the top choices for your stay in Midtown. This hotel is a short 6-minute walk from St. Louis University, and it offers free breakfast and an indoor pool.

How many hotels will I be able to find in the Midtown area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 36 Midtown hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Midtown, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to get top deals in Midtown.

What are the top things to see and do in Midtown?

Sights like Red Flag, Scott Joplin House State Historic Site and Museum of Contemporary Religious Art can be part of your cultural tour of Midtown. Chaifetz Arena and Washington Avenue Historic District are also a couple of places to visit in the neighbourhood. St. Louis Union Station, Hermann Stadium and .ZACK Theater are just a few of the places to visit in and around Midtown. While you're out sightseeing, Fubar and The Sovereign - St. Louis are a couple of additional sights to visit in St. Louis.

How can I get around Midtown and the greater St. Louis area?

Ready to get out and explore the city? Grand Station is the closest metro station.

The Best Hotels in Midtown, St. Louis - 2026 Updated Prices

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Our top choices for Midtown hotels

An outdoor patio area with seating, planters, and a grill.

1. Element by Marriott St. Louis Midtown

Midtown

Desirae

฿5,181 total

includes taxes & fees

19 Oct - 20 Oct

An outdoor patio area with seating, a fire pit, and a grill.

2. Residence Inn by Marriott St Louis Downtown

Midtown

Patrick

฿4,391 total

includes taxes & fees

25 Oct - 26 Oct

A modern bar area with a wooden bar counter, black bar stools, and a large wall with city names.

3. Fairfield Inn & Suites by Marriott St. Louis Downtown

Downtown West, 1.3 km from Midtown

Vicky

฿4,646 total

includes taxes & fees

1 Nov - 2 Nov

A rooftop terrace with outdoor seating, string lights, and a city skyline view.

4. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

0.8 km from Midtown

Skylee

฿5,009 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

5. Pear Tree Inn St. Louis Near Union Station

Downtown West, 1.2 km from Midtown

Samantha

฿4,089 total

includes taxes & fees

18 Oct - 19 Oct

An indoor pool area with a hot tub, seating, and a stone wall.

6. Drury Plaza Hotel St. Louis Union Station

Downtown West, 1.5 km from Midtown

James A.

฿4,511 total

includes taxes & fees

1 Nov - 2 Nov

A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

7. 21C Museum Hotel St Louis

Downtown West, 2.1 km from Midtown

Zane

฿6,138 total

includes taxes & fees

28 Oct - 29 Oct

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

8. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 3 km from Midtown

paullita jeanne

฿6,103 total

includes taxes & fees

1 Nov - 2 Nov

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

9. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis, 3.1 km from Midtown

Luke

฿4,717 total

includes taxes & fees

27 Oct - 28 Oct

A modern kitchen with a hexagonal tile backsplash, built-in appliances, and a central island.

10. Tru By Hilton St. Louis Downtown

Downtown West, 2.5 km from Midtown

Arthur

฿3,636 total

includes taxes & fees

1 Nov - 2 Nov

A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

11. Live by Loews - St.Louis

Downtown St. Louis, 3 km from Midtown

Molly

฿6,347 total

includes taxes & fees

25 Oct - 26 Oct

A pool area with clear water, red lounge chairs, and a view of the outside through large windows.

12. Aloft by Marriott St Louis Central West End

Central West End, 2.2 km from Midtown

Brittany

฿4,471 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

13. Hyatt Regency St. Louis at The Arch

Downtown St. Louis, 3.4 km from Midtown

Johnny

฿5,319 total

includes taxes & fees

30 Oct - 31 Oct

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

14. Comfort Inn & Suites Saint Louis Lafayette Square

The Gate, 2 km from Midtown

greg

฿4,490 total

includes taxes & fees

28 Oct - 29 Oct

An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.

15. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Downtown St. Louis, 3.5 km from Midtown

Andrew

฿4,313 total

includes taxes & fees

28 Oct - 29 Oct

A multi-story building with a classic architectural style, featuring numerous windows and a brick facade.

16. Courtyard by Marriott St. Louis Downtown/Convention Center

Downtown St. Louis, 2.9 km from Midtown

Venessa

฿4,208 total

includes taxes & fees

25 Oct - 26 Oct

A rooftop terrace with wicker furniture, offering a city view.

17. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 3.4 km from Midtown

Theresa

฿5,298 total

includes taxes & fees

27 Oct - 28 Oct

A modern hotel room with a large bed, a desk with a chair, a blue armchair, a sofa, a TV, and a large window offering a city view.

18. DoubleTree by Hilton St. Louis Forest Park

Central West End, 3.1 km from Midtown

may

฿5,887 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.

19. The Westin St. Louis

Downtown St. Louis, 2.9 km from Midtown

Stacy

฿5,492 total

includes taxes & fees

25 Oct - 26 Oct

A modern interior with hanging chairs and ottomans, large windows with a view of the street.

20. Home2 Suites by Hilton St. Louis Downtown

Downtown West, 2.5 km from Midtown

Erik

฿3,970 total

includes taxes & fees

27 Oct - 28 Oct

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Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Old Courthouse to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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Top Midtown Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

8/10 Good

"Check in was easy and staff was very nice. Room was hot and AC was not working well. 2 elevators to accommodate lots of people. Lots of wait time. Amenities were very nice. Hotel overall was very nice but could use a good scrubbing."

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"This hotel is located in a great location, close to the Gateway Arch and the ballpark where the Cardinals play. There were numerous fun restaurants within walking distance, and we felt safe except down by the Old Spaghetti Factory. I would stay in this hotel again and recommend it to others."

Clayton Plaza Hotel & Extended Stay

8/10 Good

"Hotel staff were excellent, friendly, professional and by far the best reason to re-book. The hotel itself was very clean, located near professional buildings/courts and some eateries within walking distance. The room was clean as well and nicely proportioned with some of the best mattresses/bedding I've experienced. Only slight downside was the breakfast bar--the food and choices were ample and very good (especially the made to order omelets and waffles) but the setting was less than clean and rather worn--not in keeping with the rest of the hotel. All in all, a great place to stay and would definitely book again."

Search Hotels in Midtown, St. Louis

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Our top choices for Midtown hotels

1. Element by Marriott St. Louis Midtown

2. Residence Inn by Marriott St Louis Downtown

3. Fairfield Inn & Suites by Marriott St. Louis Downtown

4. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

5. Pear Tree Inn St. Louis Near Union Station

6. Drury Plaza Hotel St. Louis Union Station

7. 21C Museum Hotel St Louis

8. Home2 Suites by Hilton St. Louis/Forest Park

9. Embassy Suites by Hilton St. Louis Downtown

10. Tru By Hilton St. Louis Downtown

11. Live by Loews - St.Louis

12. Aloft by Marriott St Louis Central West End

13. Hyatt Regency St. Louis at The Arch

14. Comfort Inn & Suites Saint Louis Lafayette Square

15. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

16. Courtyard by Marriott St. Louis Downtown/Convention Center

17. Drury Plaza Hotel St. Louis at the Arch

18. DoubleTree by Hilton St. Louis Forest Park

19. The Westin St. Louis

20. Home2 Suites by Hilton St. Louis Downtown

Where to stay in Midtown

Downtown St. Louis

Clayton

Central West End

St. Charles Historic District

Creve Coeur

Top Midtown Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

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