Midtown Travel Guide

St. Louis

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.
A sundae with chocolate ice cream and whipped cream.
A cathedral interior with Gothic architecture, including pointed arches and ribbed vaults.
A Gothic-style cathedral with intricate stonework, pointed arches, and statues.
A highway with multiple lanes, vehicles, and a bridge overhead.

Stay near popular Midtown attractions

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University during your stay in St. Louis. Wander around the area's picturesque gardens or experience its acclaimed art galleries.
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Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

฿1,071
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

฿1,171
per adult
88% of travellers recommend
St. Louis: Museum of Illusions Entry Ticket
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

฿5,523
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
Downtown St. Louis Smartphone Guided Audio Walking Tour App

Downtown St. Louis Smartphone Guided Audio Walking Tour App

฿259
per adult
100% of travellers recommend
Downtown St. Louis Smartphone Guided Audio Walking Tour App
Landmarks Downtown-West Walking Tour

Landmarks Downtown-West Walking Tour

฿669
per adult
Landmarks Downtown-West Walking Tour
Gateway Arch National Park Self Guided Audio Walking Tour

Gateway Arch National Park Self Guided Audio Walking Tour

฿502
per traveller
Gateway Arch National Park Self Guided Audio Walking Tour
See all activities in St. Louis

Top hotels in Midtown

Element by Marriott St. Louis Midtown

Element by Marriott St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is ฿4,567 per night from 16 Aug to 17 Aug
฿4,567
฿5,341 total
16 Aug - 17 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (788 reviews)
"Clean, with very comfortable beds, a great kitchenette (in my room, at least), & a better than average breakfast. Be aware that the “cooked-to-order” breakfast sounds more expansive than it really is; but it’s still better than average."

Reviewed on 24 Jul 2026

Element by Marriott St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is ฿3,992 per night from 13 Aug to 14 Aug
฿3,992
฿4,748 total
13 Aug - 14 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a 24-hour fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
7.8/10 Good! (1,001 reviews)
"I had a wonderful stay. The room was exactly what I expected."

Reviewed on 23 Jul 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ฿5,146 per night from 31 Jul to 1 Aug
฿5,146
฿6,069 total
31 Jul - 1 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,136 reviews)
"Clean room. Nice amenities. Easy walking distance to lots of activities"

Reviewed on 24 Jul 2026

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,274 per night from 9 Aug to 10 Aug
฿3,274
฿3,822 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is ฿4,398 per night from 2 Aug to 3 Aug
฿4,398
฿5,625 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (2,204 reviews)
"We paid $20pp to use the hotel shuttle.. they failed to mention the amount/number of these they were selling. By the time we got on the bus to be taken back to the hotel we could’ve walked. Others were calling Ubers to come get them after already paying for the shuttle, due to wait time. Stood in ..."

Reviewed on 23 Jul 2026

Hollywood Casino & Hotel St. Louis
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is ฿3,383 per night from 2 Aug to 3 Aug
฿3,383
฿3,983 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
Pear Tree Inn St. Louis Airport
See all 1,995 properties in Midtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

An ornate hall with arched ceilings and intricate patterns.
Photo by Terry Eaves
Open Photo by Terry Eaves

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

A modern building with a brick facade, parked cars, and a flower bed with tulips.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Midtown Travel Guide