Midtown Travel Guide

St. Louis

Midtown
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Photo by Karissa Krull
Photo by Linda Garrison
Photo by Sophie R

Popular places to visit

Things to do


Top hotels in Midtown

Element St. Louis Midtown

Element St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is ฿4,235 per night from 18 Jan to 19 Jan
฿4,235
฿4,952 total
18 Jan - 19 Jan
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (656 reviews)
Clean room, staff, location

Reviewed on 30 Dec 2025

Element St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is ฿3,576 per night from 25 Jan to 26 Jan
฿3,576
฿4,253 total
25 Jan - 26 Jan
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a 24-hour fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
7.8/10 Good! (1,001 reviews)
Staff was courteous. Breakfast was great. Bedroom and bathroom were clean.

Reviewed on 1 Jan 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
The price is ฿3,922 per night from 16 Jan to 17 Jan
฿3,922
฿4,625 total
16 Jan - 17 Jan
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (4,040 reviews)
Great view

Reviewed on 12 Jan 2026

Hyatt Regency St. Louis at The Arch
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

2.5 out of 5
333 Washington Ave St. Louis MO
The price is ฿3,061 per night from 20 Jan to 21 Jan
฿3,061
฿3,580 total
20 Jan - 21 Jan
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,215 reviews)
No, the room wasn't spotless. One of the ottomans underneath the desk has some type of white crumbs or something on it. Other than that, the hospitality was nice.

Reviewed on 11 Jan 2026

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
The price is ฿3,040 per night from 25 Jan to 26 Jan
฿3,040
฿3,615 total
25 Jan - 26 Jan
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,188 reviews)
Wonderful stay

Reviewed on 8 Jan 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
The price is ฿4,507 per night from 1 Feb to 2 Feb
฿4,507
฿5,426 total
1 Feb - 2 Feb
includes taxes & fees
Stay at this luxury hotel in St. Louis. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the pool and the restaurant in their reviews. ...
9/10 Wonderful! (1,539 reviews)
Good vibe

Reviewed on 7 Jan 2026

21C Museum Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Midtown

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The Gate

While The Gate may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like St. Louis Union Station and Busch Stadium.

The Gate
St. Louis showing interior views

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

Downtown West
Lafayette Square featuring a house and a park

Lafayette Square

The restaurants and shopping are a few reasons travellers visit Lafayette Square. Want to see more of the surrounding area? St. Louis Union Station and Busch Stadium are a few top sights nearby.

Lafayette Square
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The Grove

While there might not be top attractions in The Grove, you can explore the larger area and discover places like St. Louis Science Center and Missouri Botanical Gardens and Arboretum.

The Grove
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Shaw

Shaw might not have many top sights, but Missouri Botanical Gardens and Arboretum and St. Louis Science Center are two attractions nearby that you can check out.

Shaw
Central West End

Central West End

If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Central West End


Midtown Travel Guide