Downtown Clayton Travel Guide

St. Louis

A bronze bell with an eagle atop, surrounded by greenery and a street scene in the background.

Things to do

The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

฿5,740
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

฿787
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
The Boom Boom Room St. Louis Burlesque and Cabaret Show

St. Louis Burlesque & Nightlife Experience at The Boom Boom Room

฿1,968
per adult
St. Louis Burlesque & Nightlife Experience at The Boom Boom Room
St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

฿1,148
per adult
90% of travellers recommend
St. Louis: Museum of Illusions Entry Ticket
Saint Louis Self Guided Driving and Walking Audio Tour

St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour

฿557
per traveller
St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour
Downtown St. Louis Smartphone Guided Audio Walking Tour App

Downtown St. Louis Smartphone Guided Audio Walking Tour App

฿254
per adult
100% of travellers recommend
Downtown St. Louis Smartphone Guided Audio Walking Tour App
See all activities in St. Louis

Top hotels in Downtown Clayton

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,129 per night from 11 Oct to 12 Oct
฿3,129
฿3,653 total
11 Oct - 12 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
8.8/10 Excellent! (3,376 reviews)
"It was not much nicer than a Super 8."

Reviewed on 10 Sept 2026

Clayton Plaza Hotel & Extended Stay
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
The price is ฿4,442 per night from 13 Sept to 14 Sept
฿4,442
฿5,186 total
13 Sept - 14 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park are ...
AC Hotel St. Louis Clayton
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
The price is ฿5,286 per night from 25 Sept to 26 Sept
฿5,286
฿6,224 total
25 Sept - 26 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ...
8.8/10 Excellent! (773 reviews)
"My daughter and I had a wonderful stay! The hotel was very clean, the staff was very friendly and accommodating. The pool is awesome! There was an issue with the sink in the bathroom, however, the staff promptly moved us to another room. I blame the patron(s) prior to us that failed to report the ..."

Reviewed on 8 Sept 2026

Le Méridien St. Louis Clayton
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ฿5,005 per night from 4 Oct to 5 Oct
฿5,005
฿5,902 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,231 reviews)
"Nice hotel! Lots of amenities and very welcoming staff."

Reviewed on 10 Sept 2026

Hyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
The price is ฿4,054 per night from 2 Oct to 3 Oct
฿4,054
฿4,742 total
2 Oct - 3 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very good! (1,173 reviews)
"The rooms and hotel were nice."

Reviewed on 9 Sept 2026

Renaissance St. Louis Airport Hotel
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
The price is ฿2,961 per night from 14 Sept to 15 Sept
฿2,961
฿3,486 total
14 Sept - 15 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (3,226 reviews)
"Clean room Close to airport"

Reviewed on 9 Sept 2026

Pear Tree Inn St. Louis Airport
See all 1,966 properties in Downtown Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown Clayton

Find the best Downtown Clayton areas for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

A street corner with a 'Drunken Fish' sushi restaurant and a 'Culpeppers' grill and bar.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Downtown Clayton Travel Guide