Downtown Clayton Travel Guide

St. Louis

A bronze bell with an eagle atop, surrounded by greenery and a street scene in the background.

Things to do

St. Louis Narrated Trolley Tour

St. Louis Narrated Trolley Tour

฿984
per adult
90% of travellers recommend
St. Louis Narrated Trolley Tour
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

฿5,740
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
Saint Paul: Gray Line City Tour & Smith Avenue Bridge Stop

Saint Paul: Gray Line City Tour & Smith Avenue Bridge Stop

฿1,607
per adult
Saint Paul: Gray Line City Tour & Smith Avenue Bridge Stop
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

฿787
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
The Boom Boom Room St. Louis Burlesque and Cabaret Show

St. Louis Burlesque & Nightlife Experience at The Boom Boom Room

฿1,968
per adult
St. Louis Burlesque & Nightlife Experience at The Boom Boom Room
St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

฿1,148
per adult
90% of travellers recommend
St. Louis: Museum of Illusions Entry Ticket
See all activities in St. Louis

Top hotels in Downtown Clayton

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,113 per night from 11 Oct to 12 Oct
฿3,113
฿3,634 total
11 Oct - 12 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
8.8/10 Excellent! (3,390 reviews)
"Once again from checking in to the best breakfast to checkout everyone and everything was great"

Reviewed on 13 Sept 2026

Clayton Plaza Hotel & Extended Stay
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
The price is ฿4,016 per night from 27 Sept to 28 Sept
฿4,016
฿4,688 total
27 Sept - 28 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park are ...
9.2/10 Wonderful! (398 reviews)
"Awesome hotel I would stay there again"

Reviewed on 13 Sept 2026

AC Hotel St. Louis Clayton
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
The price is ฿5,029 per night from 4 Oct to 5 Oct
฿5,029
฿5,921 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ...
8.8/10 Excellent! (774 reviews)
"Amazing pool, spotless rooms and an amazing staff. We enjoyed the pool and lobby bars and delicious coffees and breakfast from the restaurant. Can’t wait to be back!"

Reviewed on 12 Sept 2026

Le Méridien St. Louis Clayton
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ฿5,027 per night from 4 Oct to 5 Oct
฿5,027
฿5,928 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,269 reviews)
"Perfect!"

Reviewed on 13 Sept 2026

Hyatt Regency St. Louis at The Arch
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
The price is ฿2,974 per night from 17 Sept to 18 Sept
฿2,974
฿3,502 total
17 Sept - 18 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (3,240 reviews)
"Desk employees were very happy and helpful when checking in answered any questions we had. Room very clean and comfortable. Shuttle service was on time as requested. Over all very comfortable stay.Walking distance to restaurant (Bar BQ) from motel. Will stay again at the Pear Tree Inn, by the St. ..."

Reviewed on 13 Sept 2026

Pear Tree Inn St. Louis Airport
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
The price is ฿4,072 per night from 2 Oct to 3 Oct
฿4,072
฿4,763 total
2 Oct - 3 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff ...
Renaissance St. Louis Airport Hotel
See all 1,967 properties in Downtown Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown Clayton

Find the best Downtown Clayton areas for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

A street corner with a 'Drunken Fish' sushi restaurant and a 'Culpeppers' grill and bar.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Downtown Clayton Travel Guide