Downtown Clayton Travel Guide

St. Louis

A bronze bell with an eagle atop, surrounded by greenery and a street scene in the background.

Things to do

The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

฿5,740
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

฿787
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
The Boom Boom Room St. Louis Burlesque and Cabaret Show

St. Louis Burlesque & Nightlife Experience at The Boom Boom Room

฿1,968
per adult
St. Louis Burlesque & Nightlife Experience at The Boom Boom Room
St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

฿1,148
per adult
90% of travellers recommend
St. Louis: Museum of Illusions Entry Ticket
Saint Louis Self Guided Driving and Walking Audio Tour

St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour

฿557
per traveller
St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour
Downtown St. Louis Smartphone Guided Audio Walking Tour App

Downtown St. Louis Smartphone Guided Audio Walking Tour App

฿254
per adult
100% of travellers recommend
Downtown St. Louis Smartphone Guided Audio Walking Tour App
See all activities in St. Louis

Top hotels in Downtown Clayton

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,113 per night from 11 Oct to 12 Oct
฿3,113
฿3,634 total
11 Oct - 12 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
Clayton Plaza Hotel & Extended Stay
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
The price is ฿4,462 per night from 20 Sept to 21 Sept
฿4,462
฿5,209 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park are ...
9.2/10 Wonderful! (398 reviews)
"Awesome hotel I would stay there again"

Reviewed on 13 Sept 2026

AC Hotel St. Louis Clayton
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
The price is ฿5,053 per night from 4 Oct to 5 Oct
฿5,053
฿5,949 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ...
8.8/10 Excellent! (776 reviews)
"Staff was outstanding. Location and room ideal."

Reviewed on 14 Sept 2026

Le Méridien St. Louis Clayton
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ฿5,027 per night from 1 Oct to 2 Oct
฿5,027
฿5,928 total
1 Oct - 2 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,287 reviews)
"."

Reviewed on 15 Sept 2026

Hyatt Regency St. Louis at The Arch
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is ฿2,974 per night from 21 Sept to 22 Sept
฿2,974
฿3,502 total
21 Sept - 22 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (3,247 reviews)
"Clean, comfortable and quiet. Friendly and professional staff. Parked with The Parking Spot and had the smoothest stay/transition to and from the airport. Definitely doing it again!"

Reviewed on 15 Sept 2026

Pear Tree Inn St. Louis Airport
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
The price is ฿3,693 per night from 2 Oct to 3 Oct
฿3,693
฿4,320 total
2 Oct - 3 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff ...
Renaissance St. Louis Airport Hotel
See all 1,969 properties in Downtown Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown Clayton

Find the best Downtown Clayton areas for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

A street corner with a 'Drunken Fish' sushi restaurant and a 'Culpeppers' grill and bar.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Downtown Clayton Travel Guide