Medical Center District Travel Guide

San Antonio

River walk in San Antonio
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
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Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is ฿2,576 per night from 28 May to 29 May
฿2,576
฿3,045 total
28 May - 29 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,315 reviews)
Nice stay at this Hotel, the room we stayed in (301) could use a bit of TLC. Fresh paint bathroom, tub reglazing, wood mirror frame around sink (water) area the wood was rotten and area around bathroom handle was dirty. Thanks to my Lysol wipes, I cleaned that area. The other areas in the room were ...

Reviewed on 27 Apr 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is ฿3,530 per night from 1 May to 2 May
฿3,530
฿4,195 total
1 May - 2 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,045 reviews)
Great staff and easy access

Reviewed on 27 Apr 2026

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is ฿2,983 per night from 3 May to 4 May
฿2,983
฿3,526 total
3 May - 4 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,004 reviews)
Very courteous staff, quiet area, excellent bed and amenities, convenient location for medical care, easy access to shopping and great restaurants.

Reviewed on 27 Apr 2026

Courtyard by Marriott Medical Center San Antonio
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
The price is ฿4,378 per night from 5 May to 6 May
฿4,378
฿5,175 total
5 May - 6 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,544 reviews)
Great place for familes to stay in the middle of the city.

Reviewed on 27 Apr 2026

Drury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is ฿2,884 per night from 10 May to 11 May
฿2,884
฿3,409 total
10 May - 11 May
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,451 reviews)
Very clean and quiet

Reviewed on 27 Apr 2026

Riverwalk Plaza
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
The price is ฿3,132 per night from 10 May to 11 May
฿3,132
฿3,702 total
10 May - 11 May
includes taxes & fees
Stay at this historic hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the pool and the bar in their reviews. ...
8.8/10 Excellent! (3,947 reviews)
The Hotel is in a great location. That’s all it has going for it. No one at check in told me I had to call to get my room cleaned. I called to Housekeeping Friday morning and was told they would clean it. But they didn’t come until 5pm. I was taking a nap and told them to just leave some towels. ...

Reviewed on 27 Apr 2026

Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

Northwest Side
SanAntonio_NorthStarMall_502628_05

Shearer Hills - Ridgeview

While visiting Shearer Hills - Ridgeview, you might make a stop by sights like North Star Mall and San Pedro Driving Range & Par 3 Course.

Shearer Hills - Ridgeview
River Walk in San Antonio, Texas

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or The DoSeum while you're exploring the area.

Midtown
Historic architecture Spanish San Antonio Texas Mission San Jose on a cloudy day

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
Tobin Hill

Tobin Hill

Tobin Hill might not have many top sights, but San Antonio Zoo and Aquarium and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
Dallas Skyline Reflection on Trinity River During Sunset, Dallas, Texas.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown


Medical Center District Travel Guide