The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,409 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,043 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,001 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,137 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,535 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A large, abstract sculpture with a flowing design, set against a dramatic sky.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

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A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

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A riverside walkway with colorful umbrellas, a stone bridge, and a red sculpture.

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or Historic Brackenridge Golf Course while you're exploring the area.

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Top Medical Center District Hotel Reviews

Courtyard by Marriott Medical Center San Antonio

10/10 Excellent

"Clean, friendly staff . Would book again"

JW Marriott San Antonio Hill Country Resort & Spa

8/10 Good

"Very nice facility outside of the hustle and bustle of the city. The room was clean and large, the staff were friendly. Plenty of free parking. There were numerous restaurants and bars. The pool was amazing, there were not very many people as we were there during the week but heard it can get quite crazy on the weekends. The only negative comment I had was there was construction going on for 1/2 of the hotel - refacing I believe and when we go there were told that there would be construction noise between 8-5 every day, and no water available in our room the first day after 8:30. It would have been nice to know that before we got there."

Thompson San Antonio - Riverwalk, by Hyatt

10/10 Excellent

"Overall the Hotel is top notch! Very unique and elegant and the rooms are phenomenal. Oddly enough the only complaint would be in regard to the customer service, and this is not directed to the front desk, they were amazing. But in other areas of the hotel, nothing rude or detrimental, just a lack of attentiveness. Which was unfortunate because everything else about the hotel had made such a great first impression and one could easily chalk it up to a rare "blip" in the moment. But overall it was a great experience and stay!"

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and Drury Inn & Suites San Antonio Northwest Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 130 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

USAA Corporate Office Headquarters, The San Antonio Art Institute and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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Our top choices for Medical Center District hotels

1. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2. Courtyard by Marriott Medical Center San Antonio

3. Drury Inn & Suites San Antonio Northwest Medical Center

4. Fairfield Inn & Suites by Marriott San Antonio Medical Center

5. San Antonio Marriott Northwest Medical Center

6. Park Inn by Radisson

7. OYO Inn & Suites Medical Center San Antonio

8. Studio 6 San Antonio, Tx - Northwest Medical Center

9. Motel 6 San Antonio, TX - Northwest Medical Center

10. Atria Inn & Suites

11. Studio 6 Extended Stay - San Antonio, TX - Medical Center

12. Flex Studios

13. Hyatt Place San Antonio-Northwest/Medical Center

14. Hampton Inn & Suites San Antonio Northwest/Medical Center

15. Drury Plaza Hotel San Antonio Airport

16. Holiday Inn Express San Antonio-Airport by IHG

17. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

18. Aloft by Marriott San Antonio UTSA Area

19. Comfort Inn and Suites Near Medical Center

20. Estancia del Norte San Antonio, Tapestry Collection by Hilton

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Far West Side

Uptown

La Cantera District

Midtown

Top Medical Center District Hotel Reviews

Courtyard by Marriott Medical Center San Antonio

Frequently asked questions

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