The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,407 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,047 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,004 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,143 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,562 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

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Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A large, abstract sculpture with a flowing design, set against a dramatic sky.

Uptown

If you're spending some time in Uptown, Alamo Quarry Market and San Antonio Zoo and Aquarium are top sights worth seeing.

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A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

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A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

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Top Medical Center District Hotel Reviews

Menger Hotel

8/10 Good

"The room was nice and had a large patio that we enjoyed looking over towards the Alamo. The ac was broken but they comped our stay completely and gave us a fan in our room."

Hyatt Regency San Antonio Riverwalk

10/10 Excellent

"Perfect location. Property is clean and well kept. Extremely lively on the weekend. Food and drinks at the Q Kitchen are pricey as any other hotel, but extremely delicious, fresh and clean. Valet was fast and includes 24/7 in and out privileges for $65/day. My only complaint is that my flight was delayed and I could not check in until the next day. Management refused to refund the first night which I prepaid. I think they should be a bit more lenient when it comes to scenarios like this as it’s out of the visitor’s control considering Expedia provided proof of delayed flights. Staff at check in desk was not the most welcoming either. Otherwise, my stay was great."

Spark By Hilton San Antonio Northwest near Six Flags

8/10 Good

"I wish I got the gentleman’s name but he checked us in and was so helpful. Always made sure I had everything I need. The only issue I had was the smell which I know it’s nothing they can do when it’s the guest that bring this recreational stuff in. Still and enjoyable stay!"

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and Drury Inn & Suites San Antonio Northwest Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 131 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and Cinemark San Antonio 16. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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Our top choices for Medical Center District hotels

1. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2. Fairfield Inn & Suites by Marriott San Antonio Medical Center

3. Drury Inn & Suites San Antonio Northwest Medical Center

4. Courtyard by Marriott Medical Center San Antonio

5. San Antonio Marriott Northwest Medical Center

6. Park Inn by Radisson, Medical Center

7. OYO Inn & Suites Medical Center San Antonio

8. Motel 6 San Antonio, TX - Northwest Medical Center

9. Studio 6 San Antonio, Tx - Northwest Medical Center

10. Atria Inn & Suites

11. Studio 6 Extended Stay - San Antonio, TX - Medical Center

12. Flex Studios

13. Hyatt Place San Antonio-Northwest/Medical Center

14. Hampton Inn & Suites San Antonio Northwest/Medical Center

15. Drury Inn & Suites Near La Cantera Parkway

16. Holiday Inn Express San Antonio-Airport by IHG

17. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

18. Best Western Medical Center North Inn & Suites Near Six Flags

19. Aloft by Marriott San Antonio UTSA Area

20. Comfort Inn and Suites Near Medical Center

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Uptown

Far West Side

Northwest Side

La Cantera District

Top Medical Center District Hotel Reviews

Menger Hotel

Frequently asked questions

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