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Our top choices for Panama City hotels with a spa

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1855)
"The room was impeccable, staff was awesome and very professional!!!"
United States
Scott
The price is ฿3,892
฿4,281 total
includes taxes & fees
24 Dec - 25 Dec
Riande Aeropuerto Hotel & Casino

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (562)
"Great hotel and location "
United Kingdom
Russell
The price is ฿11,905
฿13,095 total
includes taxes & fees
12 Jan - 13 Jan 2026
Sofitel Legend Casco Viejo, Panama City

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is ฿11,796
฿12,976 total
includes taxes & fees
24 Dec - 25 Dec
Hotel La Compañía Casco Antiguo

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very good, (1004)
"Great place and location, excellent food choices! "
United States
Francisco
The price is ฿7,094
฿7,803 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Westin Playa Bonita Panama

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (643)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ฿7,043
฿7,748 total
includes taxes & fees
17 Jan - 18 Jan 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1002)
"I loved everything about my stay "
United States
Stephanie
The price is ฿6,865
฿7,552 total
includes taxes & fees
10 Jan - 11 Jan 2026
Waldorf Astoria Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (994)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is ฿4,174
฿4,591 total
includes taxes & fees
9 Jan - 10 Jan 2026
Sheraton Grand Panama

W Panama

W Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1009)
"Great vibes"
United States
Ashley
The price is ฿6,449
฿7,094 total
includes taxes & fees
3 Jan - 4 Jan 2026
W Panama

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2140)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ฿4,921
฿5,413 total
includes taxes & fees
29 Dec - 30 Dec
Plaza Paitilla Inn Hotel

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
Casco Viejo
9.2 out of 10, Wonderful, (1001)
"Nice hotel in the historic center, excellent location for sightseeing and walking around at night."
United States
Antonio
The price is ฿7,929
฿8,722 total
includes taxes & fees
24 Dec - 25 Dec
Central Hotel Panama Casco Viejo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Panama City

Top Panama City attractions for a relaxing vacation

Panama City is a vibrant hub offering a unique blend of urban excitement and lush natural beauty, perfect for travellers seeking spa hotels. Start your journey at the serene Parque Metropolitano, where you can immerse yourself in nature with trails that lead to breathtaking views of the city skyline—ideal for a morning jog or a peaceful stroll before indulging in a spa treatment. Next, explore the historical Casco Viejo, a UNESCO World Heritage site, where cobblestone streets are lined with charming cafés and boutique shops, providing a lovely backdrop for leisurely afternoons. Don’t miss the Biomuseo, an architectural marvel designed by Frank Gehry, showcasing Panama’s rich biodiversity; a visit here can be paired with a rejuvenating spa experience at a nearby hotel. For a taste of local culture, the Mercado de Mariscos offers fresh seafood delicacies—consider a relaxing dinner followed by a detoxifying spa session back at your hotel. Finally, a short trip to the Panama Canal will leave you in awe of this engineering marvel; many hotels in the area offer spa packages that include canal tours, providing the perfect blend of relaxation and adventure. Staying in the upscale Punta Pacifica neighbourhood places you near luxury hotels that feature exceptional spa services, ensuring you feel pampered after a day of exploration.

The Executive Hotel

  • Why it's great for tailored spa getaway: Why it’s great: The Executive Hotel stands out with an excellent guest review rating of 9.2, offering a delightful spa experience with its steam room. This hotel caters to travelers looking to rejuvenate and relax, making it an ideal choice for spa aficionados. Its inviting atmosphere ensures guests feel welcomed and pampered throughout their stay.
  • Other amenities:
  • Other amenities: The hotel features an outdoor pool with sun umbrellas for lounging, along with complimentary breakfast options to start the day. Guests can take advantage of airport transportation services, self-parking, and concierge assistance. The hotel also offers a terrace for enjoying the warm weather, fitness facilities for an active lifestyle, and housekeeping services for a pristine environment.
  • Neighborhood: Bella Vista
  • Nearby attractions: Uruguay Street - 0.6 km, Calle 50 - 0.7 km, Avenida Balboa - 0.8 km

The Executive Hotel

  • Why it's great for tailored spa getaway: The Executive Hotel is a fantastic choice for spa enthusiasts, offering a steam room and a review rating of 9.2. This hotel provides a relaxing atmosphere, making it a great spot for guests who wish to unwind after a day of exploring Panama City.
  • Other amenities: Guests can enjoy a refreshing outdoor pool, complimentary buffet breakfast, and easy airport transportation. The hotel also features a terrace for leisure, concierge services, and free self-parking. Additional amenities include air conditioning, premium bedding, and a fitness centre, providing a well-rounded stay.
  • Neighborhood: Bella Vista
  • Nearby attractions: Uruguay Street - 0.6 km, Calle 50 - 0.7 km, Avenida Balboa - 0.8 km

Hotel Riu Plaza Panama

  • Why it's great for tailored spa getaway: The Hotel Riu Plaza Panama stands out as a premier choice for spa enthusiasts, offering a top spa with accessible treatment rooms and a guest review rating of 9.0. Travelers can indulge in a variety of treatments designed to pamper and rejuvenate, making it an ideal retreat after a day exploring the city.
  • Other amenities: Guests can enjoy a range of features including a stunning outdoor pool, complimentary buffet breakfast, and a well-equipped fitness centre. The hotel also offers valet parking, a terrace for relaxation, and an onsite shopping area for added convenience. Additional perks include a private hot tub and a concierge service to assist with local attractions.
  • Neighborhood: Bella Vista
  • Nearby attractions: Uruguay Street - 1.5 km, Calle 50 - 0 km, Via Espana - 1 km

Top Panama City Hotel Reviews

Frequently asked questions

Looking to holiday at a spa hotel in Panama City?
Forget the stress of everyday life and book yourself a hotel with a spa. Travellers highly recommend Panama City for its array of shops and gourmet restaurants—your day tour starts here. Make sure you enjoy the cafes during your stay. Spa hotels are a great way to take a break from your routine and add a layer of luxury to your holiday.
What is the best spa hotel in Panama City?
Megapolis Hotel Panamá is a top luxury spa hotel featuring 3 bars, a casino, a shopping centre and a rooftop terrace. Enjoy a facial, body scrub or detox wrap at the on-site spa. Other popular spa hotels in Panama City include Las Americas Golden Tower Panama and W Panama.
How many spa hotels are there in Panama City?
Expedia has 24 spa hotels to choose from in Panama City.
What's there to see and do in Panama City?
Enjoy Panama City with a stop at Albrook Shopping Mall, Via Espana and Iglesia del Carmen. If you have a little extra time during your trip, you might want to check out Uruguay Street and Crown Casino.
What is a Panama City spa hotel?
Spa hotels in Panama City have full on-site spas and offer services including facials and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation and relaxation.