The Best Hotels in San Francisco, Panama City - 2026 Updated Prices

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Property	Property class	Guest rating
Ramada Plaza by Wyndham Panama Punta Pacifica	4.0 star property	9.6 Exceptional 1,253 reviews	View
Courtyard by Marriott Panama Multiplaza Mall	4.0 star property	9.0 Wonderful 1,006 reviews	View
San Francisco by Wynwood House	3.0 star property	9.2 Wonderful 56 reviews	View
JW Marriott Panama	5.0 star property	9.0 Wonderful 1,003 reviews	View
Serenade Lodging Rooms	3.0 star property	8.2 Very good 26 reviews	View

Where to stay in San Francisco

Find the best San Francisco areas for the activities you enjoy most.

A coastal cityscape with buildings, a hill with a church, and a clear blue sky.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

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A spiraling skyscraper against a clear blue sky.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

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A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

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A coastal cityscape with high-rise buildings, a calm sea, and a rocky shoreline.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Estación Lotería or Santo Tomas Station to explore sights like Via Espana.

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A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

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Top San Francisco Hotel Reviews

Principe Hotel and Suites

10/10 Excellent

"Nice place! Clean, quiet, good location. For us this was great value and a great place to stay!"

JW Marriott Panama

10/10 Excellent

"Beautiful property. The staff was very helpful and friendly from the beginning! The food, restaurants, amenities, pool were all great!! The only thing that would have made it perfect was if I didn’t have a view of a huge crane outside of my patio. It appears they are having some construction going on. But other than that, it was a great experience!"

Central Hotel Panama Casco Viejo

8/10 Good

"We really enjoyed our stay in one of the family rooms. The hotel is beautiful and well maintained. The breakfast was really good. The only reason I did not rate 5 star was that the air conditioning control was not working well and the room was really cold. The staff was very friendly."

Frequently asked questions

What is San Francisco like?

San Francisco is a welcoming neighbourhood that travellers like for its restaurants. Make sure that you visit Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.

Where is the best hotel for a stay in San Francisco?

Based on our traveller data, Sheraton Grand Panama is one of the top choices for your stay in San Francisco. This resort is a short 13-minute walk from Multiplaza Pacific Mall, and it offers a full-service spa and 3 restaurants. Other good choices for your stay in the area include Las Americas Golden Tower Panama and Courtyard by Marriott Panama Multiplaza Mall.

How many hotels can I expect to find in San Francisco?

If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 323 San Francisco hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in San Francisco, will I receive a refund?

Yes! Most hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in San Francisco.

What is there to do in this Panama City neighbourhood?

While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa or Via Espana might be the perfect way to find that souvenir you've been looking for. Calle 50 and Panama Canal Murals are some other stops worth a visit in the neighbourhood. A few places to visit in the area around San Francisco include Colonial Religious Art Museum, Bingo 90 and Pacific Center. When you're sightseeing in Panama City, Soho City Center and National Shrine of the Heart of Mary are also worth a stop.

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Our top choices for San Francisco hotels

1. Serenade Lodging Rooms

2. Plaza Paitilla Inn Hotel

3. Sheraton Grand Panama

4. Megapolis Hotel Panamá

5. Living 73 Panamá by Boutique Apartments

6. Modern Apartments at the Hub City views

7. Courtyard by Marriott Panama Multiplaza Mall

8. Dovle Residences by HMS-Preferred Member

9. San Francisco by Wynwood House

10. Ramada Plaza by Wyndham Panama Punta Pacifica

11. Decapolis Hotel Panama City

12. Aloft by Marriott Panama

13. Casa Orquídea

14. Boutique Apartments Panamá Coco del Mar

15. Las Americas Golden Tower Panama

16. Stylish Apartment With Pool Gym in Panama

17. JW Marriott Panama

18. Boutique Apartments Atlapa

19. Residence Inn by Marriott Panama City

20. Modern Apartments PH Living 73 SF

Compare popular hotels in San Francisco

Where to stay in San Francisco

Casco Viejo

Bella Vista

El Cangrejo

Calidonia

San Felipe

Top San Francisco Hotel Reviews

Principe Hotel and Suites

Frequently asked questions