What is San Francisco like?

San Francisco is a welcoming neighbourhood that travellers like for its restaurants. Make sure that you visit Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.

Where is the best hotel for a stay in San Francisco?

Based on our traveller data, Megapolis Hotel Panamá is one of the top choices for your stay in San Francisco. This hotel is steps from Avenida Balboa, and offers a full-service spa and a casino. Other good choices for your stay in the area include Ramada Plaza by Wyndham Panama Punta Pacifica and Decapolis Hotel Panama City .

How many hotels can I expect to find in San Francisco?

If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 322 San Francisco hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in San Francisco, will I receive a refund?

Yes! Most hotel reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in San Francisco.

What is there to do in this Panama City neighbourhood?

While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa or Multicentro Panama might be the perfect way to find that souvenir you've been looking for. Calle 50 and Via Espana are some other stops worth a visit in the neighbourhood. A few places to visit in the area around San Francisco include Bingo 90, Pacific Center and Soho City Center. When you're sightseeing in Panama City, National Shrine of the Heart of Mary and Panama Viejo Museum are also worth a stop.

The Best Hotels in San Francisco, Panama City - 2026 Updated Prices

A bridge over a body of water with several boats.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for San Francisco hotels

A balcony with wicker chairs and a view of the cityscape.

1. Ramada Plaza by Wyndham Panama Punta Pacifica

San Francisco

Maria

฿3,902 total

includes taxes & fees

3 Oct - 4 Oct

A modern hotel with a prominent entrance, multiple floors, and a well-lit facade.

2. Aloft by Marriott Panama

San Francisco

Shaniyah

฿4,859 total

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a Marriott sign, surrounded by high-rise buildings and a busy street with cars.

3. Courtyard by Marriott Panama Multiplaza Mall

San Francisco

Holly

฿4,492 total

includes taxes & fees

26 Oct - 27 Oct

A buffet with various food items and a decorative plant.

4. Sheraton Grand Panama

San Francisco

Noel

฿6,776 total

includes taxes & fees

5 Oct - 6 Oct

A covered outdoor seating area with a view of a city skyline and water.

5. Plaza Paitilla Inn Hotel

San Francisco

Jennifer

฿4,370 total

includes taxes & fees

11 Oct - 12 Oct

A modern lobby with a glass railing, a central staircase, and a view of the cityscape through large windows.

6. Las Americas Golden Tower Panama

San Francisco

Armando

฿5,579 total

includes taxes & fees

11 Oct - 12 Oct

A poolside area with lounge chairs and a view of the ocean.

7. JW Marriott Panama

San Francisco

Nemanja

฿9,433 total

includes taxes & fees

17 Oct - 18 Oct

A high-rise building with a modern architectural design, featuring a grid of windows and balconies.

8. Megapolis Hotel Panamá

San Francisco

Sheena

฿5,899 total

includes taxes & fees

26 Oct - 27 Oct

A high-rise hotel with multiple floors, a prominent "Residence Inn by Marriott" sign, and a "Panama Clinic" sign.

9. Residence Inn by Marriott Panama City

San Francisco

Cassandre

฿6,616 total

includes taxes & fees

30 Oct - 31 Oct

A modern building with a glass facade, a curved structure, and a flat roof.

10. Decapolis Hotel Panama City

San Francisco

Jorge Luis

฿4,086 total

includes taxes & fees

12 Oct - 13 Oct

11. San Francisco by Wynwood House

San Francisco

Georg

฿4,767 total

includes taxes & fees

1 Oct - 2 Oct

A modern outdoor swimming pool with a clear view of a tall building in the background.

12. Dovle Residences by HMS-Preferred Member

San Francisco

David

฿5,921 total

includes taxes & fees

3 Oct - 4 Oct

A modern living room with a sofa, a TV, a small table, and a balcony with a view of the city.

13. Living 73 Panamá by Boutique Apartments

San Francisco

Lorenz

฿6,709 total

includes taxes & fees

30 Sept - 1 Oct

A modern living room with a sofa, a coffee table with flowers, a TV, and a large window with a city view.

14. Boutique Apartments Panamá Coco del Mar

San Francisco

purabi

฿6,441 total

includes taxes & fees

1 Oct - 2 Oct

A high-rise hotel with a modern design, featuring a prominent entrance and multiple balconies.

15. Modern Apartments at the Hub City views

San Francisco

฿4,327 total

includes taxes & fees

12 Oct - 13 Oct

A spa area with two hot tubs and lounge chairs.

16. 2BR at First del Sol Modern & Stylish

San Francisco

฿7,118 total

includes taxes & fees

30 Sept - 1 Oct

A rooftop terrace with outdoor seating, a glass kitchen area, and a view of the city skyline.

17. PAN - TH - 2B (17E)

San Francisco

฿7,118 total

includes taxes & fees

30 Sept - 1 Oct

A rooftop pool with lounge chairs, offering a city view.

18. Boutique Apartments Atlapa

San Francisco

Dustin M

฿5,055 total

includes taxes & fees

6 Oct - 7 Oct

A hotel room with a bed, a desk, and a chair. There is a window with a view of palm trees and tall buildings.

19. Casa Orquídea

San Francisco

Brett

฿2,146 total

includes taxes & fees

5 Oct - 6 Oct

A swimming pool with lounge chairs, surrounded by greenery and modern buildings.

20. Stylish 2br Apt Near the Park Omar

San Francisco

฿5,897 total

includes taxes & fees

12 Oct - 13 Oct

View all properties

Compare popular hotels in San Francisco

Property	Property class	Guest rating
Ramada Plaza by Wyndham Panama Punta Pacifica	4.0 star property	9.6 Exceptional 1,364 reviews	View
Aloft by Marriott Panama	3.5 star property	8.8 Excellent 1,014 reviews	View
Plaza Paitilla Inn Hotel	3.5 star property	9.4 Exceptional 2,246 reviews	View
Courtyard by Marriott Panama Multiplaza Mall	4.0 star property	9.0 Wonderful 1,009 reviews	View
San Francisco by Wynwood House	3.0 star property	9.2 Wonderful 63 reviews	View

Where to stay in San Francisco

Find the best San Francisco areas for the activities you enjoy most.

A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

See properties

A harbor with several boats docked in the foreground and a city skyline in the background.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

See properties

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

See properties

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

See properties

A coastal cityscape with high-rise buildings, a calm sea, and a rocky shoreline.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Lotería Station or Santo Tomás Station to explore sights like Via Espana.

See properties

Top San Francisco Hotel Reviews

Megapolis Hotel Panamá

10/10 Excellent

"I had a great stay at Megapolis. The breakfast was great and the hotel was always clean and fragrant. I would rebook this hotel on a return trip to Panama."

Hotel Riu Plaza Panama

8/10 Good

"We booked a suite, which was very spacious and had a great view. In addition to the full bathroom, there was also a convenient half bath near the entrance. The bed was comfortable, and having robes and slippers is always a nice touch. Breakfast was easily a 10/10! It was included with our stay and offered a great mix of traditional breakfast items and local cuisine. There were plenty of options, with different selections each day, which we really appreciated. The hotel was also conveniently located. Ubers were generally between 7–15 minutes to pretty much everywhere we needed to go, including the mall, restaurants and other places we visited. Overall, the service was good. It does help to know a little Spanish, as most of the employees spoke limited English, but we were still able to communicate and get what we needed. The biggest downside was the smell in the hallway leading to our room. There was a noticeable mildew/wet, stale smell, and a similar smell was also present in the room. We reported it and housekeeping came by, which helped a bit. We also purchased an air freshener during our stay to help with the smell. Washcloths weren’t always readily available and weren’t consistently replaced when the room was serviced, so we had to request them. The room also did not have a microwave, which would have been convenient. Aside from the smell, particularly in the hallway, which the hotel should definitely address, we thoroughly enjoyed our stay."

Search Hotels in San Francisco, Panama City

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for San Francisco hotels

1. Ramada Plaza by Wyndham Panama Punta Pacifica

2. Aloft by Marriott Panama

3. Courtyard by Marriott Panama Multiplaza Mall

4. Sheraton Grand Panama

5. Plaza Paitilla Inn Hotel

6. Las Americas Golden Tower Panama

7. JW Marriott Panama

8. Megapolis Hotel Panamá

9. Residence Inn by Marriott Panama City

10. Decapolis Hotel Panama City

11. San Francisco by Wynwood House

12. Dovle Residences by HMS-Preferred Member

13. Living 73 Panamá by Boutique Apartments

14. Boutique Apartments Panamá Coco del Mar

15. Modern Apartments at the Hub City views

16. 2BR at First del Sol Modern & Stylish

17. PAN - TH - 2B (17E)

18. Boutique Apartments Atlapa

19. Casa Orquídea

20. Stylish 2br Apt Near the Park Omar

Compare popular hotels in San Francisco

Where to stay in San Francisco

Casco Viejo

Bella Vista

El Cangrejo

San Felipe

Calidonia

Top San Francisco Hotel Reviews

Megapolis Hotel Panamá

Frequently asked questions