Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Stand up Paddle Board Lesson on The San Diego Bay
Tijuana: Guided City Tour with Local Food and Beer Tasting
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Top hotels in Otay Mesa
Paradise Point Resort & Spa
There were two on site restaurants. One was only open for breakfast, I believe it was close for refurbishment for dinner. The other restaurant was a little too high end for my grandkids. We had breakfast at the Barefoot Bar & Grill on our last day, it was very good and the outdoor seating right on ...
Reviewed on 10 Apr 2026
Best Western Seven Seas
Staff was great but the mini fridge didn’t work in our room.
Reviewed on 10 Apr 2026
Hard Rock Hotel San Diego
Perfect location in Gaslamp District next to Padres Stadium. Great decor with very cool staff
Reviewed on 10 Apr 2026
Handlery Hotel
Staff was pleasant and attentive and our room was cleaned daily and very well I might add. Overall, a decent value.
Reviewed on 10 Apr 2026
The DEXTRO Little Italy, BW Premier Collection
Dirty room, rundown looking hotel, right next to freeway with loud traffic noise.
Reviewed on 10 Apr 2026
Wyndham San Diego Bayside
Clean room, friendly knowledgeable staff
Reviewed on 10 Apr 2026
Other neighbourhoods around Otay Mesa
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
