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Top Trending Hotels Near Otay Mesa, San Diego

Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout curtains, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1003)
"Clean, friendly staff and yummy breakfast :)"
The price is ฿3,216
฿3,658 total
includes taxes & fees
12 Oct - 13 Oct
Quality Suites San Diego Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
8.0 out of 10, Very good, (1475)
"Very good to stayed "
The price is ฿3,352
฿3,813 total
includes taxes & fees
15 Oct - 16 Oct
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Palihotel San Diego Gaslamp Quarter
Rooftop terrace

Palihotel San Diego Gaslamp Quarter

4.0 star property
8.8 out of 10, Excellent, (1897)
"Staff was great location was great"
The price is ฿3,771
฿4,372 total
includes taxes & fees
3 Nov - 4 Nov
Palihotel San Diego Gaslamp Quarter
Hotel Zindel
Terrace/patio

Hotel Zindel

2.0 star property
7.6 out of 10, Good, (551)
"Nice place and you could walk to most places of interest "
Hotel Zindel
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Exterior

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
9.0 out of 10, Wonderful, (1155)
"Clean room ,friendly staff, great location "
The price is ฿4,670
฿5,415 total
includes taxes & fees
20 Oct - 21 Oct
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
The Horton Grand, Downtown/Gaslamp Quarter
Serves dinner and happy hour

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
9.0 out of 10, Wonderful, (2588)
"Great location and friendly staff"
The Horton Grand, Downtown/Gaslamp Quarter
Gaslamp Plaza Suites
Lobby

Gaslamp Plaza Suites

3.5 star property
8.8 out of 10, Excellent, (1009)
"Had a great stay "
The price is ฿3,513
฿3,996 total
includes taxes & fees
13 Oct - 14 Oct
Gaslamp Plaza Suites
Wyndham San Diego Bayside
Terrace/patio

Wyndham San Diego Bayside

4.0 star property
8.4 out of 10, Very good, (5982)
"Great stay near the airport."
The price is ฿4,942
฿6,672 total
includes taxes & fees
12 Oct - 13 Oct
Wyndham San Diego Bayside
Hard Rock Hotel San Diego
Outdoor pool

Hard Rock Hotel San Diego

4.0 star property
9.0 out of 10, Wonderful, (2994)
"Loved staying here. Will definitely stay again "
The price is ฿5,823
฿8,244 total
includes taxes & fees
31 Oct - 1 Nov
Hard Rock Hotel San Diego
Ramada Suites by Wyndham San Diego/Hotel Circle Area
Outdoor pool

Ramada Suites by Wyndham San Diego/Hotel Circle Area

2.5 star property
6.2 out of 10, (1020)
"Clean room, friendly staff"
The price is ฿2,457
฿2,824 total
includes taxes & fees
14 Oct - 15 Oct
Ramada Suites by Wyndham San Diego/Hotel Circle Area
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3314)
"Nice place to stay !"
The price is ฿4,648
฿5,122 total
includes taxes & fees
15 Oct - 16 Oct
Best Western Plus Marina Gateway Hotel
El Cordova Hotel on Coronado Island
Lobby

El Cordova Hotel on Coronado Island

3.5 star property
8.8 out of 10, Excellent, (1005)
"Cute and unique hotel！"
El Cordova Hotel on Coronado Island
Staypineapple, Hotel Z, Gaslamp San Diego
Premium bedding, pillow-top beds, desk, blackout curtains

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great staff and clean rooms"
The price is ฿4,830
฿6,539 total
includes taxes & fees
30 Oct - 31 Oct
Staypineapple, Hotel Z, Gaslamp San Diego
The Sofia Hotel
Front of property

The Sofia Hotel

3.5 star property
8.4 out of 10, Very good, (1606)
"I loved the stay here, highly recommended "
The Sofia Hotel
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Lobby sitting area

AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

4.0 star property
8.8 out of 10, Excellent, (933)
"Would definitely stay again!"
The price is ฿5,489
฿6,364 total
includes taxes & fees
13 Oct - 14 Oct
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Super 8 by Wyndham El Cajon/San Diego
Lobby

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.8 out of 10, Good, (1003)
"Great place "
The price is ฿2,319
฿2,555 total
includes taxes & fees
19 Oct - 20 Oct
Super 8 by Wyndham El Cajon/San Diego
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1042)
"Beautiful quiet hotel."
The price is ฿6,473
฿8,665 total
includes taxes & fees
26 Oct - 27 Oct
Loews Coronado Bay Resort
The Bristol Hotel San Diego
Property entrance

The Bristol Hotel San Diego

3.5 star property
8.4 out of 10, Very good, (1394)
"Very nice staff from check in, clean rooms, quiet and comfortable. "
The Bristol Hotel San Diego
Days Inn by Wyndham Chula Vista/San Diego
Lobby

Days Inn by Wyndham Chula Vista/San Diego

2.0 star property
6.2 out of 10, (1015)
"We feel safe and clean, the lobby service people are nice. "
The price is ฿2,323
฿2,559 total
includes taxes & fees
12 Oct - 13 Oct
Days Inn by Wyndham Chula Vista/San Diego
Days Inn by Wyndham San Diego-East/El Cajon
Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1006)
"Place was nice and comfy. Decent stay at a very genuine price. "
The price is ฿2,568
฿2,830 total
includes taxes & fees
19 Oct - 20 Oct
Days Inn by Wyndham San Diego-East/El Cajon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa Hotel Reviews

The Little Italy Hotel Downtown San Diego

The Little Italy Hotel Downtown San Diego

10/10 Excellent
"Clean room clean bathroom staff was friendly. Wi-Fi worked easily. I would definitely book again."
Hassani 2-night trip
Posted 2 days ago
The Little Italy Hotel Downtown San Diego

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.