Search Hotels in Otay Mesa, San Diego

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
4 Aug - 5 Aug
Tomorrow
5 Aug - 6 Aug
This weekend
8 Aug - 10 Aug
Next weekend
15 Aug - 17 Aug

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Otay Mesa, San Diego

Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout curtains, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1005)
"Great location and spacious room "
The price is ฿3,543
฿4,030 total
includes taxes & fees
5 Aug - 6 Aug
Quality Suites San Diego Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.8 out of 10, Good, (1415)
"Great stay, close to the Cross Border Xpress "
The price is ฿3,836
฿4,363 total
includes taxes & fees
10 Aug - 11 Aug
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Hotel Zindel
Terrace/patio

Hotel Zindel

2.0 star property
7.6 out of 10, Good, (510)
"Convenient location , very response staff , good value for money"
Hotel Zindel
Wyndham San Diego Bayside
Terrace/patio

Wyndham San Diego Bayside

4.0 star property
8.4 out of 10, Very good, (5803)
"Great stay!"
The price is ฿4,946
฿6,668 total
includes taxes & fees
1 Sept - 2 Sept
Wyndham San Diego Bayside
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Exterior

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
9.0 out of 10, Wonderful, (1044)
"We had a great stay!"
The price is ฿4,395
฿5,087 total
includes taxes & fees
1 Sept - 2 Sept
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
The Horton Grand, Downtown/Gaslamp Quarter
Serves dinner and happy hour

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
9.0 out of 10, Wonderful, (2442)
"good location, historic hotel "
The Horton Grand, Downtown/Gaslamp Quarter
Palihotel San Diego Gaslamp Quarter
Rooftop terrace

Palihotel San Diego Gaslamp Quarter

4.0 star property
8.8 out of 10, Excellent, (1590)
"Great hotel highly recommended"
The price is ฿3,072
฿4,472 total
includes taxes & fees
27 Aug - 28 Aug
Palihotel San Diego Gaslamp Quarter
Hard Rock Hotel San Diego
Outdoor pool

Hard Rock Hotel San Diego

4.0 star property
9.0 out of 10, Wonderful, (2784)
"Amazing stay"
The price is ฿5,360
฿7,709 total
includes taxes & fees
25 Aug - 26 Aug
Hard Rock Hotel San Diego
Gaslamp Plaza Suites
Lobby

Gaslamp Plaza Suites

3.5 star property
8.8 out of 10, Excellent, (1007)
"I love their clean bathrooms and been able to choose a suite over a standard room also been "
The price is ฿3,543
฿4,030 total
includes taxes & fees
7 Aug - 8 Aug
Gaslamp Plaza Suites
Best Western Plus Suites Hotel Coronado Island
Outdoor pool, pool loungers

Best Western Plus Suites Hotel Coronado Island

2.5 star property
8.8 out of 10, Excellent, (1004)
"Great area"
The price is ฿6,718
฿7,390 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Plus Suites Hotel Coronado Island
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3186)
"This location was great for our family get away"
The price is ฿4,652
฿5,126 total
includes taxes & fees
1 Sept - 2 Sept
Best Western Plus Marina Gateway Hotel
Staypineapple, Hotel Z, Gaslamp San Diego
Premium bedding, pillow-top beds, desk, blackout curtains

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
9.4 out of 10, Exceptional, (1007)
"Great place"
The price is ฿4,340
฿5,962 total
includes taxes & fees
6 Aug - 7 Aug
Staypineapple, Hotel Z, Gaslamp San Diego
El Cordova Hotel on Coronado Island
Lobby

El Cordova Hotel on Coronado Island

3.5 star property
8.8 out of 10, Excellent, (1005)
"Loved our stay at El Cordova Hotel! The on-site restaurant was super convenient, the whole place had a cozy, homey vibe, and we were just minutes from Coronado Beach. Excellent experience all around!"
The price is ฿8,232
฿9,071 total
includes taxes & fees
1 Sept - 2 Sept
El Cordova Hotel on Coronado Island
The Sofia Hotel
Front of property

The Sofia Hotel

3.5 star property
8.4 out of 10, Very good, (1508)
"Great stay"
The Sofia Hotel
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Lobby sitting area

AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

4.0 star property
8.8 out of 10, Excellent, (887)
"This is my favorite hotel in San Diego for value along with pool and gym."
The price is ฿5,754
฿6,660 total
includes taxes & fees
13 Aug - 14 Aug
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1014)
"Loved our stay very accommodating "
The price is ฿6,469
฿8,660 total
includes taxes & fees
1 Sept - 2 Sept
Loews Coronado Bay Resort
Super 8 by Wyndham El Cajon/San Diego
Lobby

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.8 out of 10, Good, (1007)
"Great place "
The price is ฿3,218
฿3,540 total
includes taxes & fees
5 Aug - 6 Aug
Super 8 by Wyndham El Cajon/San Diego
Bay Club Hotel & Marina
Exterior

Bay Club Hotel & Marina

3.5 star property
9.0 out of 10, Wonderful, (2765)
"Great place to stay"
The price is ฿4,944
฿5,683 total
includes taxes & fees
1 Sept - 2 Sept
Bay Club Hotel & Marina
The Bristol Hotel San Diego
Property entrance

The Bristol Hotel San Diego

3.5 star property
8.4 out of 10, Very good, (1353)
"Great stay"
The Bristol Hotel San Diego
Days Inn by Wyndham San Diego-East/El Cajon
Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1001)
"Cozy bed, very quiet and convenient"
The price is ฿3,288
฿3,623 total
includes taxes & fees
1 Sept - 2 Sept
Days Inn by Wyndham San Diego-East/El Cajon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Belmont Park featuring a park and rides
Mission Beach map

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Gaslamp Quarter featuring a bar, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach map

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa Hotel Reviews

The Little Italy Hotel Downtown San Diego

The Little Italy Hotel Downtown San Diego

10/10 Excellent
" The stay was great family friendly walking distance to a lot of restaurant . 10/10 "
Yesenia 2-night trip
Posted 23 hours ago
The Little Italy Hotel Downtown San Diego

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodation options, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.