Otay Mesa Travel Guide

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Things to do


Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
The price is ฿4,510 per night from 5 Oct to 6 Oct
฿4,510
฿5,130 total
5 Oct - 6 Oct
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very good! (1,864 reviews)
"Good value option but with some opportunities in overall cleaning for the room and amenities. In general was a good stay"

Reviewed on 6 Sept 2026

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is ฿7,769 per night from 10 Sept to 11 Sept
฿7,769
฿10,801 total
10 Sept - 11 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (2,853 reviews)
"Had some concern about the air conditioning of room , hotel staff looked into the same. Day 1 night was tough , but Day 2 night was fine with AC working good"

Reviewed on 7 Sept 2026

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is ฿5,008 per night from 20 Sept to 21 Sept
฿5,008
฿6,953 total
20 Sept - 21 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
8.4/10 Very good! (6,322 reviews)
"The hotel is old and smelled grungy. I asked for a room away from noise and received a room next to the elevator with chimed all night. I would not recommend this hotel especially for the price."

Reviewed on 7 Sept 2026

Wyndham San Diego Bayside
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is ฿6,845 per night from 4 Oct to 5 Oct
฿6,845
฿9,610 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...
Paradise Point Resort & Spa
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
The price is ฿5,288 per night from 29 Sept to 30 Sept
฿5,288
฿7,025 total
29 Sept - 30 Sept
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. Popular attractions ...
The Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is ฿5,629 per night from 28 Sept to 29 Sept
฿5,629
฿8,116 total
28 Sept - 29 Sept
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...
9/10 Wonderful! (4,332 reviews)
"Room was out dated the carpet needs to be replaced and the ac did not reach its full potential, the room never got cold. The staff was great but for the price i paid i expected MORE."

Reviewed on 7 Sept 2026

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.



Otay Mesa Travel Guide