Otay Mesa Travel Guide

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area or simply enjoy its restaurants.
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Things to do

Kayak on the San Diego Bay

Kayak on the San Diego Bay

฿669
per adult
Kayak on the San Diego Bay
Tijuana Downtown Self Guided Walking Tour

Tijuana Downtown Self Guided Walking Tour

฿326
per adult
100% of travellers recommend
Tijuana Downtown Self Guided Walking Tour
Picture 3 for Activity Tijuana: Guided City Tour with Local Food and Beer Tasting

Tijuana: Guided City Tour with Local Food and Beer Tasting

฿3,809
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
Tijuana Urban Art Walk from San Diego

Tijuana Urban Art Walk from San Diego

฿2,678
per adult
Tijuana Urban Art Walk from San Diego
Taco Tuesday Hop to Tijuana from San Diego

Taco Tuesday Hop to Tijuana from San Diego

฿2,778
per adult
Taco Tuesday Hop to Tijuana from San Diego
From Tijuana: Valle de Guadalupe Private Winery Tour

From Tijuana: Valle de Guadalupe Private Winery Tour

฿4,761
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
See all activities in San Diego

Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
The price is ฿4,752 per night from 12 Aug to 13 Aug
฿4,752
฿5,405 total
12 Aug - 13 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very good! (1,836 reviews)
"Happy with are stay"

Reviewed on 11 Aug 2026

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is ฿7,379 per night from 7 Sept to 8 Sept
฿7,379
฿10,232 total
7 Sept - 8 Sept
includes taxes & fees
Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...
Paradise Point Resort & Spa
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
The price is ฿5,984 per night from 6 Sept to 7 Sept
฿5,984
฿8,740 total
6 Sept - 7 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (2,791 reviews)
"The place was great I highly recommend."

Reviewed on 11 Aug 2026

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is ฿5,020 per night from 24 Aug to 25 Aug
฿5,020
฿6,969 total
24 Aug - 25 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Wyndham San Diego Bayside
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
The price is ฿6,249 per night from 7 Sept to 8 Sept
฿6,249
฿8,133 total
7 Sept - 8 Sept
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. Popular attractions ...
9/10 Wonderful! (4,465 reviews)
"Near bay"

Reviewed on 10 Aug 2026

The Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is ฿5,553 per night from 12 Aug to 13 Aug
฿5,553
฿8,032 total
12 Aug - 13 Aug
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...
Hard Rock Hotel San Diego
See all 4,900 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A beach with surfers and swimmers during sunset.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Otay Mesa Travel Guide