Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
San Diego USS Midway with Waterfront Walking Tour
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
San Diego Shopping Tour to Las Amercias Outlet
Top hotels in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Reviewed on 16 Jul 2025
Handlery Hotel
Reviewed on 15 Jul 2025
Wyndham San Diego Bayside
Reviewed on 16 Jul 2025
Manchester Grand Hyatt San Diego
Reviewed on 15 Jul 2025
Marriott Marquis San Diego Marina
Reviewed on 16 Jul 2025
The Dana on Mission Bay
Reviewed on 16 Jul 2025
Other neighbourhoods around Otay Mesa
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.