Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Things to do
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
Stand up Paddle Board Lesson on The San Diego Bay
Top hotels in Otay Mesa
Handlery Hotel
Clean room awesome staff and quiet space
Reviewed on 19 Oct 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Everyone was friendly
Reviewed on 22 Oct 2025
Comfort Inn San Diego Airport At The Harbor
Nice clean room. Everything was great.
Reviewed on 19 Oct 2025
Pendry San Diego
The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!
Reviewed on 15 Oct 2025
Wyndham San Diego Bayside
Older property but great location. Friendly staff and lots nearby.
Reviewed on 20 Oct 2025
Hilton San Diego Mission Valley
Something was going on at the hotel and it smelled like poop all over the place.
Reviewed on 20 Oct 2025
Other neighbourhoods around Otay Mesa
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
