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Our top choices for Museum of Life and Science hotels

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
1.4 km from Museum of Life and Science
9.0 out of 10, Wonderful, (1006)
"Very clean hotel. Staff was very pleasant and helpful."
United States
Brenda
The price is ฿3,586
฿4,070 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.2 km from Museum of Life and Science
8.8 out of 10, Excellent, (959)
"Room was clean, staff was courteous"
United States
John
The price is ฿3,051
฿3,464 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Durham by IHG
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.2 km from Museum of Life and Science
8.6 out of 10, Excellent, (1001)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is ฿2,880
฿3,269 total
includes taxes & fees
30 Jan - 31 Jan 2026
Comfort Inn & Suites Durham near Duke University
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.2 km from Museum of Life and Science
6.8 out of 10, (1000)
"Good motel...clean, easy acess "
United States
Howard
The price is ฿1,826
฿2,126 total
includes taxes & fees
11 Jan - 12 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
Apartment | 1 bedroom
Walk to Duke Campus 1 Bedroom in Trinity Park

Walk to Duke Campus 1 Bedroom in Trinity Park

Walk to Duke Campus 1 Bedroom in Trinity Park
2.0 star property
Trinity Park, 2.9 km from Museum of Life and Science
6.0 out of 10, (2)
"Fantastic neighborhood. Nice apartment - very neat and tidy. Easy to find, good communication with management company. Would stay here again. "
United States
Brittney
The price is ฿2,477
฿5,125 total
includes taxes & fees
25 Jan - 26 Jan 2026
Walk to Duke Campus 1 Bedroom in Trinity Park
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 3.4 km from Museum of Life and Science
9.2 out of 10, Wonderful, (1001)
"Just right for an overnight business trip "
United States
Cody
The price is ฿3,125
฿3,547 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hilton Garden Inn Durham/University Medical Center
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 3.3 km from Museum of Life and Science
9.2 out of 10, Wonderful, (461)
"Hotel was great - very friendly staff."
United States
Lisa
The price is ฿4,212
฿4,781 total
includes taxes & fees
29 Jan - 30 Jan 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
4.8 km from Museum of Life and Science
9.6 out of 10, Exceptional, (403)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is ฿3,586
฿4,070 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Durham University Medical Center
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
4.6 km from Museum of Life and Science
9.2 out of 10, Wonderful, (457)
"Extremely clean room, nice fragrance throughout the hotel, and friendly staff."
United States
Mary
The price is ฿2,957
฿3,356 total
includes taxes & fees
4 Jan - 5 Jan 2026
SpringHill Suites by Marriott Durham City View
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
4.9 km from Museum of Life and Science
9.2 out of 10, Wonderful, (621)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is ฿3,717
฿4,219 total
includes taxes & fees
4 Jan - 5 Jan 2026
AC Hotel Durham
Indoor pool
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
5.9 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1002)
"Family friendly! "
United States
Tanisha
The price is ฿5,033
฿5,713 total
includes taxes & fees
29 Jan - 30 Jan 2026
Washington Duke Inn & Golf Club
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4 km from Museum of Life and Science
8.8 out of 10, Excellent, (1000)
"Great place"
United States
Chase
The price is ฿3,586
฿4,071 total
includes taxes & fees
1 Jan - 2 Jan 2026
University Inn Durham next to Duke University Medical Center
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 3.6 km from Museum of Life and Science
9.0 out of 10, Wonderful, (645)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is ฿5,852
฿6,641 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Durham Hotel
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.1 km from Museum of Life and Science
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is ฿5,600
฿6,355 total
includes taxes & fees
18 Jan - 19 Jan 2026
Aloft Durham Downtown
Garden
Arrowhead Inn

Arrowhead Inn

Arrowhead Inn
4.5 star property
9.8 km from Museum of Life and Science
9.8 out of 10, Exceptional, (119)
"Bed was very comfortable, breakfast was yummy, and the surroundings were beautiful"
United States
Ronald
The price is ฿6,172
฿7,005 total
includes taxes & fees
1 Jan - 2 Jan 2026
Arrowhead Inn
BBQ/picnic Area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown
3.0 star property
Croasdaile Farm Master, 3.3 km from Museum of Life and Science
8.2 out of 10, Very good, (1001)
"Great place "
United States
Silvia
The price is ฿3,048
฿3,460 total
includes taxes & fees
1 Jan - 2 Jan 2026
Courtyard Durham Near Duke University/Downtown
Front of property
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center
3.0 star property
4 km from Museum of Life and Science
8.4 out of 10, Very good, (1000)
"Room was clean and great customer service. "
United States
Anne
The price is ฿4,058
฿4,606 total
includes taxes & fees
1 Jan - 2 Jan 2026
The Lodge at Duke Medical Center
Seasonal outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas
Hilton Durham near Duke University

Hilton Durham near Duke University

Hilton Durham near Duke University
3.5 star property
5.2 km from Museum of Life and Science
8.4 out of 10, Very good, (1000)
"Everything is great staff was awesome "
United States
Kristina
The price is ฿3,328
฿3,777 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hilton Durham near Duke University
Exterior
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt
3.5 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.2 out of 10, Very good, (1001)
"We stay here at least annually and always will. "
United States
Paul
The price is ฿3,995
฿5,070 total
includes taxes & fees
11 Jan - 12 Jan 2026
Unscripted Durham, Part of JDV by Hyatt
Interior entrance
21c Museum Hotel Durham

21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.4 out of 10, Very good, (1002)
"Amazing staff, comfortable rooms, best shower, convenient location. "
United States
Lauren
The price is ฿5,054
฿5,893 total
includes taxes & fees
25 Jan - 26 Jan 2026
21c Museum Hotel Durham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Museum of Life and Science Hotel Reviews

Super 8 by Wyndham Durham/University Area NC

Super 8 by Wyndham Durham/University Area NC

6/10 Okay
"The TV did not work, the shower did not work, the internet too slow to be useful at all, the sheets were ratty and the walls dirty. The only good part was the staff. Everyone I met who worked there was VERY nice, helpful and personable."
Peter 1-night trip
Posted 7 months ago
Super 8 by Wyndham Durham/University Area NC

Hotels near other Museum of Life and Science attractions

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
See properties

Vietnam Veterans Living Memorial

You can find out about the history of Durham with a trip to Vietnam Veterans Living Memorial. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Museum of Life and Science?
Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 10 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Museum of Life and Science?
Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.8 mi (1.4 km) from Museum of Life and Science. Other good options within 5 miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.
How many hotels can I expect to find close to Museum of Life and Science?
Expedia has 10 hotels and other accommodation options within a mile from Museum of Life and Science.
If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Museum of Life and Science.
What can I see and do near Museum of Life and Science?
You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.