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Our top choices for Duke Homestead hotels

Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
3.1 km from Duke Homestead
9.6 out of 10, Exceptional, (403)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is ฿3,586
฿4,070 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Durham University Medical Center
Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
2.5 km from Duke Homestead
9.0 out of 10, Wonderful, (1006)
"Very clean hotel. Staff was very pleasant and helpful."
United States
Brenda
The price is ฿3,586
฿4,070 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
1.1 km from Duke Homestead
8.8 out of 10, Excellent, (959)
"Room was clean, staff was courteous"
United States
John
The price is ฿3,051
฿3,464 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Durham by IHG
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 1.4 km from Duke Homestead
8.6 out of 10, Excellent, (1001)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is ฿2,880
฿3,269 total
includes taxes & fees
30 Jan - 31 Jan 2026
Comfort Inn & Suites Durham near Duke University
BBQ/picnic Area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown
3.0 star property
Croasdaile Farm Master, 1.5 km from Duke Homestead
8.2 out of 10, Very good, (1001)
"Great place "
United States
Silvia
The price is ฿3,048
฿3,460 total
includes taxes & fees
1 Jan - 2 Jan 2026
Courtyard Durham Near Duke University/Downtown
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
0.8 km from Duke Homestead
6.8 out of 10, (1000)
"Good motel...clean, easy acess "
United States
Howard
The price is ฿1,826
฿2,126 total
includes taxes & fees
11 Jan - 12 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
Outdoor pool
Royal Inn

Royal Inn

Royal Inn
2.0 star property
2.9 km from Duke Homestead
5.8 out of 10, (1027)
"It was ok"
United States
Precious
The price is ฿2,516
฿2,856 total
includes taxes & fees
1 Jan - 2 Jan 2026
Royal Inn
Garden
Arrowhead Inn

Arrowhead Inn

Arrowhead Inn
4.5 star property
9.1 km from Duke Homestead
9.8 out of 10, Exceptional, (119)
"Bed was very comfortable, breakfast was yummy, and the surroundings were beautiful"
United States
Ronald
The price is ฿6,172
฿7,005 total
includes taxes & fees
1 Jan - 2 Jan 2026
Arrowhead Inn
Indoor pool
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
5.4 km from Duke Homestead
9.4 out of 10, Exceptional, (1002)
"Family friendly! "
United States
Tanisha
The price is ฿5,033
฿5,713 total
includes taxes & fees
29 Jan - 30 Jan 2026
Washington Duke Inn & Golf Club
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 3.4 km from Duke Homestead
9.2 out of 10, Wonderful, (1001)
"Just right for an overnight business trip "
United States
Cody
The price is ฿3,125
฿3,547 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hilton Garden Inn Durham/University Medical Center
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
4 km from Duke Homestead
9.2 out of 10, Wonderful, (621)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is ฿3,717
฿4,219 total
includes taxes & fees
4 Jan - 5 Jan 2026
AC Hotel Durham
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 4 km from Duke Homestead
9.2 out of 10, Wonderful, (461)
"Hotel was great - very friendly staff."
United States
Lisa
The price is ฿4,212
฿4,781 total
includes taxes & fees
29 Jan - 30 Jan 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
5.6 km from Duke Homestead
9.2 out of 10, Wonderful, (457)
"Extremely clean room, nice fragrance throughout the hotel, and friendly staff."
United States
Mary
The price is ฿2,957
฿3,356 total
includes taxes & fees
4 Jan - 5 Jan 2026
SpringHill Suites by Marriott Durham City View
Property grounds
Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel
4.0 star property
15.9 km from Duke Homestead
9.6 out of 10, Exceptional, (1001)
"Breakfast was fabulous!"
United States
Cindy
The price is ฿5,589
฿6,343 total
includes taxes & fees
1 Jan - 2 Jan 2026
Rizzo Center, a Destination by Hyatt Hotel
Terrace/patio
The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel
4.0 star property
16.7 km from Duke Homestead
9.6 out of 10, Exceptional, (266)
"The room was great. Very clean. The staff was absolutely amazing! 10 out of 10! "
United States
Stuart
The price is ฿4,225
฿4,795 total
includes taxes & fees
21 Jan - 22 Jan 2026
The Colonial Inn, an Ascend Collection Hotel
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 4.8 km from Duke Homestead
9.0 out of 10, Wonderful, (645)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is ฿5,852
฿6,641 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Durham Hotel
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 5.1 km from Duke Homestead
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is ฿5,600
฿6,355 total
includes taxes & fees
18 Jan - 19 Jan 2026
Aloft Durham Downtown
Outdoor pool, pool loungers
Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint
3.0 star property
15.5 km from Duke Homestead
9.4 out of 10, Exceptional, (1005)
"Daily room cleaning and staff friendliness."
United States
Janet
The price is ฿4,247
฿4,820 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hyatt Place Durham Southpoint
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
3.3 km from Duke Homestead
8.8 out of 10, Excellent, (1000)
"Great place"
United States
Chase
The price is ฿3,586
฿4,070 total
includes taxes & fees
1 Jan - 2 Jan 2026
University Inn Durham next to Duke University Medical Center
Terrace/patio
Residence Inn by Marriott Chapel Hill

Residence Inn by Marriott Chapel Hill

Residence Inn by Marriott Chapel Hill
3.0 star property
13.6 km from Duke Homestead
9.2 out of 10, Wonderful, (524)
"Great customer service. Clean and well maintained."
United States
Susanne
The price is ฿3,984
฿4,522 total
includes taxes & fees
15 Jan - 16 Jan 2026
Residence Inn by Marriott Chapel Hill
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Duke Homestead Hotel Reviews

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

10/10 Excellent
"Excellent"
Christian 2-night trip
Posted 13 days ago
The Lodge at Duke Medical Center

Hotels near other Duke Homestead attractions

Sennett's hole is a swimming hole accessed from the west point outpost on the eno river. There are lots of rocks to lounge on on one side, and a rope swing on the other. It's great spot to hang out!
Photo by Nikki Benson
Open Photo by Nikki Benson

West Point on the Eno

Explore the great outdoors at West Point on the Eno, a lovely green space in Durham. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties
Beautiful Japanese garden at Duke
Photo by Pon Xayavong Photography
Open Photo by Pon Xayavong Photography

Sarah P. Duke Gardens

Explore the great outdoors at Sarah P. Duke Gardens, a lovely green space in Durham. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Duke Homestead?
Duke Homestead is located in a family-friendly area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 41 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Duke Homestead?
Comfort Inn & Suites Durham near Duke University is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located just a short 0.9 mi (1.4 km) from Duke Homestead. Other good choices within a short distance include Red Roof Inn Durham - Duke Univ Medical Center and Holiday Inn Express Durham by IHG.
How many hotels should I expect to find close to Duke Homestead?
Expedia has 41 hotels and other accommodation options within a mile from Duke Homestead.
If I need to cancel the hotel reservation for my stay near Duke Homestead, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to get the top deals on offer near Duke Homestead.
What can I see and do near Duke Homestead?
Study the collections at Museum of Life and Science, Nasher Museum of Art at Duke University or Bennett Place. Explore notable local landmarks like Cameron Indoor Stadium, Wallace Wade Stadium and American Tobacco Campus. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.