A colonial-style building with a bell tower, palm trees, and a paved walkway.

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Our top choices for Santa Cruz luxury hotels

Reception

Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (433 reviews)
  • cleanliness
    Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
The price is ฿5,399
฿5,399 total
1 Aug - 2 Aug
Camino Real Hotel
Outdoor pool, pool umbrellas, pool loungers

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (236 reviews)
  • cleanliness
    Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
The price is ฿4,068
฿4,068 total
25 Jul - 26 Jul
Marriott Santa Cruz de la Sierra Hotel
Exterior detail

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (166 reviews)
The price is ฿3,266
฿3,266 total
13 Jul - 14 Jul
TRYP by Wyndham Santa Cruz
Lobby sitting area

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (120 reviews)
  • cleanliness
    Indulge in art deco elegance at this Santa Cruz hotel with luxurious pools and concierge service.
The price is ฿4,415
฿4,415 total
4 Aug - 5 Aug
Novotel Santa Cruz De La Sierra
Massages

Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (87 reviews)
  • cleanliness
    Indulge in spa treatments, outdoor pool relaxation, and friendly concierge service at this entertainment district luxury retreat.
The price is ฿3,351
฿3,351 total
27 Jul - 28 Jul
Swissôtel Santa Cruz De La Sierra
Lounge

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (279 reviews)
  • cleanliness
    Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
The price is ฿2,450
฿2,450 total
1 Aug - 2 Aug
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent
"Great property, in a very safe location that is close to good places to eat. Staff are very professional. Sr. Domingos who cooks the eggs at breakfast went above and beyond! All the pools are fantastic and the room wa large with a very, very comfortable bed. I would stay here again"
Lyle 4-night trip
Posted less than an hour ago
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 6 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Blacutt Square, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Camino Real Hotel and Novotel Santa Cruz De La Sierra are two other upscale options for your trip.
How many luxury hotels are there in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 6 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Blacutt Square and Ramon Tahuichi Aguilera Stadium. If you have a little extra time during your trip, you might want to make a stop at Cine Center and Santa Cruz Zoo.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To venture out into the surrounding area, hop aboard a train at Santa Cruz de la Sierra Station.