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Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,002 reviews)
"Great staff, breakfast and happy hour. "
United States
Tina
The price is ฿12,214
฿13,741 total
includes taxes & fees
26 May - 27 May
Almond Tree Inn Hotel - Adults Only

The Gardens Hotel

The Gardens Hotel
4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,000 reviews)
"Breakfasts were great and they had a very good selection of drinks at the bar."
United States
Dennis
The price is ฿9,984
฿11,232 total
includes taxes & fees
11 May - 12 May
The Gardens Hotel

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,002 reviews)
"Great stay"
United States
Julia
The price is ฿12,214
฿13,741 total
includes taxes & fees
26 May - 27 May
Orchid Key Inn - Adults Only

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (258 reviews)
"Fabulous staff, our villa had everything we needed, perfect location off Duval with a peaceful vibe at the swimming pool and patio, and the happy hour cocktails were the best! "
United States
Sarah
The price is ฿10,168
฿11,439 total
includes taxes & fees
14 May - 15 May
Key West Villas

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,000 reviews)
"Great accommodations and great staff"
United States
Julian
The price is ฿11,621
฿14,895 total
includes taxes & fees
10 May - 11 May
The Marquesa Hotel

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (941 reviews)
"Very unique, great staff, and great location"
United States
Jason
The price is ฿11,021
฿12,399 total
includes taxes & fees
4 May - 5 May
Simonton Court Historic Inn & Cottages

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (367 reviews)
"Clean cute hotel close to Duvall"
United States
Marsha
The price is ฿6,403
฿7,923 total
includes taxes & fees
3 May - 4 May
Douglas House - Adults Only

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (395 reviews)
"We stayed for three nights and it was a great place. The room was lovely with a balcony overlooking the pool. It’s a great location, within walking distance of everything. Brandy was very helpful and accommodating, making sure everything went well with our stay. Would definitely come back again."
Canada
Lisa
The price is ฿7,734
฿9,513 total
includes taxes & fees
3 May - 4 May
Tropical Inn

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (166 reviews)
"The breakfast was fantastic! Located close enough to Duval for convenience but far enough to be quiet. "
United States
Bob
The price is ฿13,130
฿14,771 total
includes taxes & fees
11 May - 12 May
The Conch House Heritage Inn

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (599 reviews)
"This resort was in the perfect location for exploring Key West. Highly recommend!"
United States
Barton
The price is ฿14,858
฿18,901 total
includes taxes & fees
25 May - 26 May
H2O Suites - Adults Only

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (974 reviews)
"This was a lovely well stocked, and comfortable stay."
United States
Pat
The price is ฿6,115
฿6,880 total
includes taxes & fees
3 May - 4 May
L'Habitation Guest House

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,026 reviews)
"Great place & location !!"
United States
Carl
The price is ฿7,445
฿9,075 total
includes taxes & fees
24 May - 25 May
Duval House

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,004 reviews)
"We absolutely loved staying here!"
United States
Victoria E
The price is ฿8,795
฿9,895 total
includes taxes & fees
13 May - 14 May
Island City House Hotel

Marrero's Guest Mansion

Marrero's Guest Mansion
3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (337 reviews)
"It was nice. Get a smart tv 😂"
United States
Robert
The price is ฿10,046
฿11,302 total
includes taxes & fees
20 May - 21 May
Marrero's Guest Mansion

Caribbean House

Caribbean House
3.0 star property
Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (351 reviews)
"Very convenient location."
United States
Miguel
The price is ฿9,980
฿12,037 total
includes taxes & fees
3 May - 4 May
Caribbean House

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
3.5 star property
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (142 reviews)
"Staff very courteous and friendly, public spaces lovely."
United States
Paul
The price is ฿5,823
฿7,853 total
includes taxes & fees
3 May - 4 May
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,000 reviews)
"Nice suites , staff very friendly. Conveniently located. Check your room bills carefully. "
United States
Kristine
The price is ฿12,269
฿15,987 total
includes taxes & fees
25 May - 26 May
Santa Maria Suites

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,002 reviews)
"Breakfast by the pool was excellent! Pools were nice, with plenty of areas for privacy. We especially enjoyed the private patios and courtyards. Fantastic location!"
United States
Tina
The price is ฿8,200
฿9,225 total
includes taxes & fees
4 May - 5 May
Ambrosia Key West

Heron House - Adult Only

Heron House - Adult Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,147 reviews)
"Love the Heron House, it s quaint and very comfortable, we absolutely love our stays there. "
United States
Burt
The price is ฿4,839
฿6,556 total
includes taxes & fees
7 May - 8 May
Heron House - Adult Only

Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
4.0 star property
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,006 reviews)
"Fresh continental breakfast, clean room, close to everything."
United States
BOBBY J.
The price is ฿7,743
฿12,808 total
includes taxes & fees
26 May - 27 May
Southernmost House - Adult Exclusive
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Almond Tree Inn Hotel - Adults Only
3.5 star property
10.0
Exceptional
1,002 reviews
View
Exterior detail
The Gardens Hotel
4.0 star property
9.8
Exceptional
1,000 reviews
View
Property grounds
Orchid Key Inn - Adults Only
3.5 star property
9.8
Exceptional
1,002 reviews
View
Front of property
Key West Villas
3.5 star property
9.8
Exceptional
258 reviews
View
Exterior
The Marquesa Hotel
3.5 star property
9.8
Exceptional
1,000 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Hotels near other Florida Keys National Marine Sanctuary attractions

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1542 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Pier House Resort & Spa.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1542 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society and Red Barn Theater if you're interested in local theatre.