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Check prices for these dates

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28 Apr - 29 Apr
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29 Apr - 30 Apr
This weekend
1 May - 3 May
Next weekend
8 May - 10 May

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Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,002 reviews)
"Great staff, breakfast and happy hour. "
United States
Tina
The price is ฿12,057
฿13,564 total
includes taxes & fees
5 May - 6 May
Almond Tree Inn Hotel - Adults Only
Property grounds

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,002 reviews)
"Great stay"
United States
Julia
The price is ฿12,162
฿13,682 total
includes taxes & fees
26 May - 27 May
Orchid Key Inn - Adults Only
Front of property

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (258 reviews)
"Fabulous staff, our villa had everything we needed, perfect location off Duval with a peaceful vibe at the swimming pool and patio, and the happy hour cocktails were the best! "
United States
Sarah
Key West Villas
Exterior

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,000 reviews)
"Great accommodations and great staff"
United States
Julian
The price is ฿11,621
฿14,895 total
includes taxes & fees
25 May - 26 May
The Marquesa Hotel
Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (941 reviews)
"Very unique, great staff, and great location"
United States
Jason
The price is ฿10,974
฿12,345 total
includes taxes & fees
3 May - 4 May
Simonton Court Historic Inn & Cottages
Exterior

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (366 reviews)
"Clean cute hotel close to Duvall"
United States
Marsha
The price is ฿6,340
฿7,846 total
includes taxes & fees
6 May - 7 May
Douglas House - Adults Only
Veranda Room | Terrace/patio

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (166 reviews)
"The breakfast was fantastic! Located close enough to Duval for convenience but far enough to be quiet. "
United States
Bob
The price is ฿12,741
฿14,334 total
includes taxes & fees
17 May - 18 May
The Conch House Heritage Inn
11 Gecko's Garden - Adults Only | Premium bedding, pillow-top beds, individually decorated

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (395 reviews)
"We stayed for three nights and it was a great place. The room was lovely with a balcony overlooking the pool. It’s a great location, within walking distance of everything. Brandy was very helpful and accommodating, making sure everything went well with our stay. Would definitely come back again."
Canada
Lisa
The price is ฿6,498
฿8,119 total
includes taxes & fees
29 Apr - 30 Apr
Tropical Inn
Exterior

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (520 reviews)
"Great location, pleasant staff & cute pool. "
United States
julie
The price is ฿9,992
฿11,241 total
includes taxes & fees
3 May - 4 May
Coco Plum Inn
Property grounds

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,026 reviews)
"Great place & location !!"
United States
Carl
The price is ฿7,373
฿8,986 total
includes taxes & fees
11 May - 12 May
Duval House
Front of property

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (974 reviews)
"This was a lovely well stocked, and comfortable stay."
United States
Pat
The price is ฿6,089
฿6,850 total
includes taxes & fees
3 May - 4 May
L'Habitation Guest House
Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave | Free WiFi, bed sheets

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
3.5 star property
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (142 reviews)
"Staff very courteous and friendly, public spaces lovely."
United States
Paul
The price is ฿5,798
฿7,819 total
includes taxes & fees
3 May - 4 May
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,004 reviews)
"We absolutely loved staying here!"
United States
Victoria E
The price is ฿8,795
฿9,895 total
includes taxes & fees
13 May - 14 May
Island City House Hotel
2 outdoor pools, pool loungers

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,000 reviews)
"Nice suites , staff very friendly. Conveniently located. Check your room bills carefully. "
United States
Kristine
The price is ฿12,269
฿15,987 total
includes taxes & fees
25 May - 26 May
Santa Maria Suites
Front of property

Caribbean House

Caribbean House
3.0 star property
Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (351 reviews)
"Very convenient location."
United States
Miguel
The price is ฿7,118
฿8,817 total
includes taxes & fees
29 Apr - 30 Apr
Caribbean House
Courtyard

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,000 reviews)
"This is a great place to stay, quiet and nice accommodations. Awesome little courtyard for breakfast."
United States
Jacqueline
The price is ฿8,506
฿10,378 total
includes taxes & fees
29 Apr - 30 Apr
The Grand Guesthouse
3 outdoor pools, a heated pool, pool loungers

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,002 reviews)
"Breakfast by the pool was excellent! Pools were nice, with plenty of areas for privacy. We especially enjoyed the private patios and courtyards. Fantastic location!"
United States
Tina
The price is ฿8,165
฿9,186 total
includes taxes & fees
4 May - 5 May
Ambrosia Key West
Porch

Heron House - Adult Only

Heron House - Adult Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,146 reviews)
"Love the Heron House, it s quaint and very comfortable, we absolutely love our stays there. "
United States
Burt
The price is ฿4,398
฿6,042 total
includes taxes & fees
5 May - 6 May
Heron House - Adult Only
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers

Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (467 reviews)
"Amazing hotel, great staff, perfect location. 10/10 - we cant wait to come back for another visit and book there again!"
United States
Caitlin
The price is ฿12,916
฿16,170 total
includes taxes & fees
26 May - 27 May
Ella's Cottages - Key West Historic Inns
Outdoor pool

Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
3.5 star property
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,027 reviews)
"Great location and very nice ataff"
Australia
fernando
The price is ฿5,506
฿8,380 total
includes taxes & fees
3 May - 4 May
Silver Palms Inn & Historic Homes
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Almond Tree Inn Hotel - Adults Only
3.5 star property
10.0
Exceptional
1,002 reviews
View
Property grounds
Orchid Key Inn - Adults Only
3.5 star property
9.8
Exceptional
1,002 reviews
View
Front of property
Key West Villas
3.5 star property
9.8
Exceptional
258 reviews
View
Exterior
The Marquesa Hotel
3.5 star property
9.8
Exceptional
1,000 reviews
View
Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished
Simonton Court Historic Inn & Cottages
2.5 star property
9.8
Exceptional
941 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

10/10 Excellent
"We had an amazing time! All staff was incredible, from front desk to the beach and pools. Cant wait to go back next year!!!"
Holly 7-night trip
Posted 3 hours ago
Southernmost Beach Resort and Guesthouses

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1542 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Pier House Resort & Spa.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1542 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society and Red Barn Theater if you're interested in local theatre.