Uptown Travel Guide

Collinsville

A tall water tower with a red and white striped top, surrounded by trees and a clear blue sky.
A tall, cylindrical structure with a red and white striped pattern and a label reading "Brock's Old Original Catsup."

Stay near popular Uptown attractions

Things to do


Top hotels in Uptown

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is ฿5,007 per night from 4 Oct to 5 Oct
฿5,007
฿5,904 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,231 reviews)
"It was a beautiful hotel."

Reviewed on 8 Sept 2026

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,412 per night from 5 Oct to 6 Oct
฿3,412
฿3,983 total
5 Oct - 6 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
The price is ฿4,440 per night from 5 Oct to 6 Oct
฿4,440
฿5,192 total
5 Oct - 6 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.6/10 Exceptional! (3,745 reviews)
"Great breakfast"

Reviewed on 8 Sept 2026

Drury Plaza Hotel St. Louis at the Arch
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
3550 Samuel Sheppard Drive St. Louis MO
The price is ฿4,156 per night from 2 Oct to 3 Oct
฿4,156
฿4,901 total
2 Oct - 3 Oct
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.8/10 Excellent! (1,157 reviews)
"Love the art work and the moody colors of the rooms."

Reviewed on 8 Sept 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

3.5 out of 5
333 Washington Ave St. Louis MO
Fully refundableReserve now, pay when you stay
The price is ฿4,019 per night from 14 Sept to 15 Sept
฿4,019
฿4,699 total
14 Sept - 15 Sept
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,395 reviews)
"Stayed 1 night with my spouse and teen. Proximity to City museum was good, walkable if weather was good. Parking was less expensive than at similar nearby hotels. We had an abundance of towels in our room which was nice. Dislikes: our room was a little rundown, particularly the bathroom. Fixture ..."

Reviewed on 7 Sept 2026

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
The price is ฿4,729 per night from 4 Oct to 5 Oct
฿4,729
฿5,694 total
4 Oct - 5 Oct
includes taxes & fees
Stay at this luxury hotel in St. Louis. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the pool and the restaurant in their reviews. ...
9/10 Wonderful! (2,101 reviews)
"Love this hotel. Great stay for our entire family."

Reviewed on 8 Sept 2026

21C Museum Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Uptown

Find the best Uptown areas for the activities you enjoy most.

Eastport

While visiting Eastport, you might make a stop by sights like Gateway Conference Center and Splash City Family Waterpark.

Mulberry Hills

Though Mulberry Hills may not have many top sights, you can venture to the surrounding area to see attractions like Gateway Conference Center and FanDuel Sportsbook and Horse Racing.

Historic Downtown Collinsville

Though Historic Downtown Collinsville may not have many top sights, you can venture to the surrounding area to see attractions like Gateway Conference Center and Splash City Family Waterpark.



Uptown Travel Guide