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4 Nov - 5 Nov
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5 Nov - 6 Nov
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6 Nov - 8 Nov
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13 Nov - 15 Nov

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Our top choices for Uptown Greenville hotels

A modern hotel with a stone facade, large windows, and a well-lit entrance.

1. Hilton Garden INN Greenville University

Hilton Garden INN Greenville University
3.0 star property
Uptown Greenville
9.4 out of 10, Exceptional, (180 reviews)
"Really nice and new hotel."
United States
Sharon
The price is ฿5,232
฿5,912 total
includes taxes & fees
22 Nov - 23 Nov
Hilton Garden INN Greenville University
A multi-story hotel with a prominent entrance, large columns, and a landscaped front yard.

2. Holiday Inn Express Greenville by IHG

Holiday Inn Express Greenville by IHG
2.5 star property
2.3 km from Uptown Greenville
8.4 out of 10, Very good, (1,000 reviews)
"The room was a nice roomy size & attractive. Breakfast was pretty good & a pleasant area also."
United States
charles
The price is ฿3,308
฿3,738 total
includes taxes & fees
2 Dec - 3 Dec
Holiday Inn Express Greenville by IHG
A circular fire pit with seating around it, a covered patio area, and a brick building in the background.

3. Homewood Suites By Hilton Greenville, NC

Homewood Suites By Hilton Greenville, NC
3.0 star property
2.4 km from Uptown Greenville
9.4 out of 10, Exceptional, (455 reviews)
"Lovely property, great place to stay here in Greenville"
United States
Leonardo
The price is ฿4,124
฿4,661 total
includes taxes & fees
22 Nov - 23 Nov
Homewood Suites By Hilton Greenville, NC
An indoor swimming pool with clear markings, a "NO DIVING" sign, and a view of parked cars outside.

4. Fairfield Inn & Suites by Marriott Greenville

Fairfield Inn & Suites by Marriott Greenville
3.0 star property
2.4 km from Uptown Greenville
8.6 out of 10, Excellent, (517 reviews)
"The property was very nice and clean. The staff was very helpful. The shower water was nice and hot. I did experience a drainage problem in the sink. Overall, the stay was nice and comfortable."
United States
Lakisa
The price is ฿4,692
฿5,302 total
includes taxes & fees
15 Nov - 16 Nov
Fairfield Inn & Suites by Marriott Greenville
An outdoor patio area with a fire pit, seating, and umbrellas.

5. Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville
3.0 star property
2.4 km from Uptown Greenville
8.8 out of 10, Excellent, (545 reviews)
"Great time"
United States
Jayvon
The price is ฿3,882
฿4,387 total
includes taxes & fees
8 Nov - 9 Nov
Residence Inn by Marriott Greenville
Property amenity

6. Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG
3.0 star property
2.3 km from Uptown Greenville
9.2 out of 10, Wonderful, (390 reviews)
"Brand new, very clean, big rooms! Would definitely stay again!"
United States
Tamara
The price is ฿4,085
฿4,616 total
includes taxes & fees
8 Nov - 9 Nov
Staybridge Suites Greenville Medical Center by IHG
A Courtyard by Marriott hotel with a covered entrance, outdoor seating, and a landscaped area.

7. Courtyard Marriott Greenville

Courtyard Marriott Greenville
3.0 star property
Medical District, 2.8 km from Uptown Greenville
8.8 out of 10, Excellent, (951 reviews)
"Staff was nice, wish coffee was served later. Great staff"
United States
Anthony J
The price is ฿3,988
฿4,507 total
includes taxes & fees
9 Nov - 10 Nov
Courtyard Marriott Greenville
A modern dining area with a large window, a chandelier, and a patterned sofa.

8. Quality Inn Greenville near University

Quality Inn Greenville near University
2.5 star property
2 km from Uptown Greenville
7.4 out of 10, Good, (1,000 reviews)
"Overall stay was pretty good it was Halloween weekend so we were surrounded by a bunch of college kids only complaint I have is the alarm clock in the room kept making noise even after it was turned off I don't know what was going on with it"
United States
Lucretia
The price is ฿2,410
฿2,724 total
includes taxes & fees
29 Nov - 30 Nov
Quality Inn Greenville near University
A hotel room with a desk, two beds, a sofa, a TV, and a coffee machine.

9. Best Western Plus Suites-Greenville

Best Western Plus Suites-Greenville
2.5 star property
3.9 km from Uptown Greenville
9.0 out of 10, Wonderful, (1,000 reviews)
"Had a great stay of 4 days"
United States
Thomas
The price is ฿3,861
฿4,363 total
includes taxes & fees
9 Nov - 10 Nov
Best Western Plus Suites-Greenville
A multi-story hotel with a covered entrance, large windows, and a brick facade.

10. Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic
2.0 star property
2.5 km from Uptown Greenville
7.0 out of 10, Good, (1,000 reviews)
"Very comfortable and cozy place to stay customer service was on point"
United States
Stephen
The price is ฿2,152
฿2,432 total
includes taxes & fees
8 Nov - 9 Nov
Microtel Inn & Suites by Wyndham Greenville/University Medic
An indoor swimming pool with clear windows, a lifeguard sign, and a pool depth marker.

11. Hampton Inn Greenville

Hampton Inn Greenville
2.5 star property
Convention District, 4.3 km from Uptown Greenville
9.0 out of 10, Wonderful, (686 reviews)
"Front desk was very helpful!"
United States
Victor
The price is ฿4,131
฿4,667 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Greenville
A hotel entrance with a prominent 'Super 8' sign, brick facade, and potted plants.

12. Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville
2.0 star property
2.3 km from Uptown Greenville
6.6 out of 10, (619 reviews)
"Great location and friendly staff"
United States
Sharlene
The price is ฿2,668
฿3,015 total
includes taxes & fees
8 Nov - 9 Nov
Super 8 by Wyndham Greenville
A hotel lobby with a reception desk, seating area, and a television screen.

13. Holiday Inn Greenville by IHG

Holiday Inn Greenville by IHG
3.0 star property
Convention District, 4.3 km from Uptown Greenville
8.8 out of 10, Excellent, (1,001 reviews)
"Great place, comfortable rooms"
United States
Jonathan
The price is ฿2,903
฿3,281 total
includes taxes & fees
2 Dec - 3 Dec
Holiday Inn Greenville by IHG
A spacious lobby with a blue sofa, yellow armchairs, a central coffee table, and a wooden balcony railing.

14. Comfort Inn & Suites Greenville Near East Carolina University

Comfort Inn & Suites Greenville Near East Carolina University
2.5 star property
4.9 km from Uptown Greenville
8.8 out of 10, Excellent, (566 reviews)
"It was a decent stay!"
United States
Thomelane
The price is ฿3,730
฿4,215 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn & Suites Greenville Near East Carolina University
An outdoor patio with seating, a fire pit, and string lights.

15. Hilton Greenville

Hilton Greenville
4.0 star property
Convention District, 4.5 km from Uptown Greenville
8.8 out of 10, Excellent, (583 reviews)
"Best hotel in Greenville when you can’t get the place downtown!"
United States
Sara
The price is ฿5,232
฿5,912 total
includes taxes & fees
18 Nov - 19 Nov
Hilton Greenville
A hotel room with two beds, each with patterned bedding, a bedside table with a lamp, and a framed picture on the wall.

16. Motel 6 Greenville, NC – ECU-Medical Center

Motel 6 Greenville, NC – ECU-Medical Center
2.0 star property
2.2 km from Uptown Greenville
6.4 out of 10, (136 reviews)
"Very nice place to stay at"
United States
Joey
The price is ฿2,464
฿2,784 total
includes taxes & fees
5 Nov - 6 Nov
Motel 6 Greenville, NC – ECU-Medical Center
A spacious lobby with a high ceiling, a large window, a ceiling fan, a brown leather sofa, a glass coffee table with flowers, a patterned rug, and a red carpet.

17. Econo Lodge Greenville near University

Econo Lodge Greenville near University
2.0 star property
2.3 km from Uptown Greenville
7.2 out of 10, Good, (479 reviews)
"Nice place, is great for a whole family, close to beaches."
United States
Gerardo
The price is ฿2,566
฿2,900 total
includes taxes & fees
8 Nov - 9 Nov
Econo Lodge Greenville near University
A hotel entrance with a sign reading 'Candlewood Suites.' There are potted plants and a mailbox in the foreground.

18. Candlewood Suites Greenville NC by IHG

Candlewood Suites Greenville NC by IHG
2.5 star property
4.7 km from Uptown Greenville
8.4 out of 10, Very good, (681 reviews)
"Room was very clean, staff was super friendly and helpful. 10/10 would stay here again."
United States
Gabriel
The price is ฿2,971
฿3,357 total
includes taxes & fees
8 Nov - 9 Nov
Candlewood Suites Greenville NC by IHG
A hotel room with two beds, a red armchair, a sofa, and a desk.

19. Country Inn & Suites by Radisson, Greenville, NC

Country Inn & Suites by Radisson, Greenville, NC
3.0 star property
6.7 km from Uptown Greenville
7.6 out of 10, Good, (942 reviews)
"Definitely will stay again. Clean room. Everyone was super friendly"
United States
Frances
The price is ฿3,433
฿3,892 total
includes taxes & fees
30 Nov - 1 Dec
Country Inn & Suites by Radisson, Greenville, NC
A clean, well-lit room with a tiled floor, a counter with a cash register, and a sign detailing room rates and policies.

20. Economy Inn of Greenville, NC

Economy Inn of Greenville, NC
2.5 star property
2.1 km from Uptown Greenville
4.4 out of 10, (120 reviews)
"Clean room very basic room. No coffee potor coffee/ hot water available even in front desk area. Staff was courteous sir conditioning was very good. Food and shops near by. My only complaint was they use flat sheet as bottom sheet and it didn't begin to fit the bed."
United States
Buyer
The price is ฿1,695
฿1,916 total
includes taxes & fees
19 Nov - 20 Nov
Economy Inn of Greenville, NC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Uptown Greenville

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern hotel with a stone facade, large windows, and a well-lit entrance.
Hilton Garden INN Greenville University
3.0 star property
9.4
Exceptional
180 reviews
View
A circular fire pit with seating around it, a covered patio area, and a brick building in the background.
Homewood Suites By Hilton Greenville, NC
3.0 star property
9.4
Exceptional
455 reviews
View
Property amenity
Staybridge Suites Greenville Medical Center by IHG
3.0 star property
9.2
Wonderful
390 reviews
View
A multi-story hotel with a prominent entrance, large columns, and a landscaped front yard.
Holiday Inn Express Greenville by IHG
2.5 star property
8.4
Very good
1,000 reviews
View
A hotel room with a desk, two beds, a sofa, a TV, and a coffee machine.
Best Western Plus Suites-Greenville
2.5 star property
9.0
Wonderful
1,000 reviews
View

Where to stay in Uptown Greenville

Find the best Uptown Greenville areas for the activities you enjoy most.

University District

While University District isn't home to many top sights, Dowdy–Ficklen Stadium and Williams Arena at Minges Coliseum are some notable places to visit nearby.

Convention District

When in Convention District, you can plan a visit to University Commons and 11 Galleria, some noteworthy sights in the nearby area.

Medical District

If you're looking for some top things to see and do in Medical District and surrounding area, you can visit Arlington Crossing and South Greenville Park.

Westhaven

Westhaven might not have many top sights, but 11 Galleria and University Commons are two attractions nearby that you can check out.

Greenville Heights

If you're looking for some top things to see and do in Greenville Heights and surrounding area, you can visit Williams Arena at Minges Coliseum and Dowdy–Ficklen Stadium.

Top Uptown Greenville Hotel Reviews

Property amenity
Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG

Staybridge Suites Greenville Medical Center by IHG
Greenville

10/10 Excellent

Room was super clean, nice and spacious. Shower was a little disappointing water pressure wise. Breakfast was ok, but no fresh fruit.
United Kingdom
Alastair
Reviewed July 26, 2026
Staybridge Suites Greenville Medical Center by IHG

Frequently Asked Questions

What is Uptown Greenville like?

Travellers will be sure to find plenty to entertain them in Greenville's Uptown Greenville neighbourhood. Are you looking for Uptown Greenville travel tips? Make sure that you visit Greenville Museum of Art and Town Common while you're in the neighbourhood.

What's a favourite place to stay in Uptown Greenville?

Based on our traveller data, Hilton Garden INN Greenville University is one of the top choices for your stay in Uptown Greenville. This hotel is a short 3-minute walk from East Carolina University, and it offers a restaurant and a 24-hour fitness centre.

If I need to cancel my hotel reservation in Uptown Greenville, will I receive a refund?

Yes, the majority of hotel room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view top deals in Uptown Greenville.

What is there to do around this Greenville neighbourhood?

A few attractions you might want to check out while you're in Uptown Greenville are Greenville Museum of Art and Town Common. Shepherd Memorial Library - Carver Branch and North Pines are also worth a visit when you're out sightseeing in Greenville.