The Best Hotels in Southampton, Houston - 2026 Updated Prices

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Our top choices for Southampton hotels

A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

1. Hyatt Place Houston Medical Center

Texas Medical Center, 3 km from Southampton

Jorge

฿4,948 total

includes taxes & fees

11 Oct - 12 Oct

A rooftop pool area with lounge chairs and a view of a tall building at night.

2. The Westin Houston Medical Center/Museum District

Texas Medical Center, 1.6 km from Southampton

Juan

฿5,961 total

includes taxes & fees

26 Sept - 27 Sept

A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

3. Hilton Houston Plaza/Medical Center

Texas Medical Center, 1.5 km from Southampton

olga

฿4,152 total

includes taxes & fees

1 Oct - 2 Oct

A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

4. Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 2.7 km from Southampton

Angela

฿6,367 total

includes taxes & fees

11 Oct - 12 Oct

A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

4.4 km from Southampton

Kevin

฿4,616 total

includes taxes & fees

5 Oct - 6 Oct

A person sitting on a white lounge chair with a striped towel, reading a book.

6. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 1.5 km from Southampton

Amehed

฿2,596 total

includes taxes & fees

12 Oct - 13 Oct

An outdoor patio area with round wooden tables and wicker chairs, featuring a lantern and modern lighting fixtures.

7. Hilton Garden Inn Houston Medical Center, TX

Texas Medical Center, 3.1 km from Southampton

Tameka

฿4,433 total

includes taxes & fees

18 Oct - 19 Oct

8. Hyatt House Houston Medical Center

Texas Medical Center, 3 km from Southampton

Gaby

฿5,231 total

includes taxes & fees

12 Oct - 13 Oct

A hotel lobby with a hot tub, a pool, and a dining area.

9. Drury Inn & Suites Houston Near the Galleria

The Galleria, 5.4 km from Southampton

Andrei

฿3,642 total

includes taxes & fees

27 Sept - 28 Sept

A modern living room with a glass table, a sofa, a TV, and a staircase with a city view.

10. DoubleTree by Hilton Hotel Houston - Greenway Plaza

Greenway Plaza-Upper Kirby, 2.4 km from Southampton

Chloe

฿4,576 total

includes taxes & fees

7 Oct - 8 Oct

A hotel room with a sofa, ottoman, desk, and a bed.

11. Hyatt Place Houston/Galleria

5.9 km from Southampton

Brynant

฿4,595 total

includes taxes & fees

15 Oct - 16 Oct

A spacious living area with a dining table, chairs, and a chandelier.

12. Hotel Zaza Houston Museum District

2 km from Southampton

Tina

฿11,702 total

includes taxes & fees

24 Oct - 25 Oct

A restaurant with multiple dining tables, chairs, and a large chandelier.

13. Embassy Suites by Hilton Houston Downtown Convention Center

5.8 km from Southampton

Vanity

฿6,006 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

14. The Royal Sonesta Houston Galleria

The Galleria, 5.3 km from Southampton

Dr. Zurick

฿5,580 total

includes taxes & fees

27 Sept - 28 Sept

A rooftop pool area with a covered seating area, a pool with a metal railing, and a cityscape view in the background.

15. Holiday Inn Express Houston - Galleria Area by IHG

The Galleria, 5 km from Southampton

Kaylyn

฿4,908 total

includes taxes & fees

25 Sept - 26 Sept

A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

16. Courtyard By Marriott Houston Medical Center Reliant Park

2.9 km from Southampton

Jorge

฿4,369 total

includes taxes & fees

22 Oct - 23 Oct

A modern indoor pool area with a wooden table and chairs, a vase with flowers, and a view of the outside buildings.

17. Best Western Plus Downtown Inn & Suites

5 km from Southampton

ROMAN

฿4,505 total

includes taxes & fees

29 Sept - 30 Sept

A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

18. Home2 Suites by Hilton at the Galleria

Greater Uptown, 5.6 km from Southampton

Alexis

฿4,099 total

includes taxes & fees

29 Sept - 30 Sept

A hotel lobby with seating areas, a reception desk, and a decorative partition.

19. Hampton Inn Houston Downtown Convention Center

6.2 km from Southampton

Dagoberto

฿4,628 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

20. Comfort Suites Houston near Medical Center- NRG Stadium

3.7 km from Southampton

Brad

฿3,664 total

includes taxes & fees

22 Oct - 23 Oct

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Where to stay in Southampton

Find the best Southampton areas for the activities you enjoy most.

A sculpture garden with abstract art pieces in a city park.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

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A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

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A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

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A modern building with a covered outdoor area and a circular garden feature.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

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A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

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Top Southampton Hotel Reviews

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

10/10 Excellent

"No one was at the desk in the morning lack of ownership"

Grand Tuscany Hotel

8/10 Good

"Good price for a comfortable stay. Clean, comfortable restaurant and bar. Our room key needed to be corrected a couple of times on a 3 night stay. It was quiet when we slept, but the pool seemed to make it a party destination where 2 low class women threw a wad of gum in the pool. We'd stay here again for the price and the pool. All but 1 staff were helpful."

Frequently asked questions

What is Southampton like?

Travellers will be sure to enjoy their time in Houston's Southampton neighbourhood.

If I need to cancel my hotel reservation in Southampton, will I receive a refund?

Yes, you'll find most room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view top deals in Southampton.

What can I see and do in this Houston neighbourhood?

A few places to visit in the area around Southampton include Reliant Stadium, Twilight Epiphany Skyspace and Rice Stadium. When you're sightseeing in Houston, Anderson Clarke Center and Main Street Theater - Rice Village are also worth a stop.

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Our top choices for Southampton hotels

1. Hyatt Place Houston Medical Center

2. The Westin Houston Medical Center/Museum District

3. Hilton Houston Plaza/Medical Center

4. Blossom Hotel Houston, Curio Collection by Hilton

5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

6. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

7. Hilton Garden Inn Houston Medical Center, TX

8. Hyatt House Houston Medical Center

9. Drury Inn & Suites Houston Near the Galleria

10. DoubleTree by Hilton Hotel Houston - Greenway Plaza

11. Hyatt Place Houston/Galleria

12. Hotel Zaza Houston Museum District

13. Embassy Suites by Hilton Houston Downtown Convention Center

14. The Royal Sonesta Houston Galleria

15. Holiday Inn Express Houston - Galleria Area by IHG

16. Courtyard By Marriott Houston Medical Center Reliant Park

17. Best Western Plus Downtown Inn & Suites

18. Home2 Suites by Hilton at the Galleria

19. Hampton Inn Houston Downtown Convention Center

20. Comfort Suites Houston near Medical Center- NRG Stadium

Where to stay in Southampton

Downtown Houston

The Galleria

Texas Medical Center

Montrose

Houston Central Business District

Top Southampton Hotel Reviews

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Frequently asked questions

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