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Check prices for these dates

Tonight
7 Mar - 8 Mar
Tomorrow
8 Mar - 9 Mar
Next weekend
13 Mar - 15 Mar
In two weeks
20 Mar - 22 Mar

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Our top choices for Santa Lucia hotels

Rooftop terrace

Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (267 reviews)
"Valentina & Malvina"
United States
Andrew
The price is ฿4,194
฿4,982 total
includes taxes & fees
8 Mar - 9 Mar
Caportigia Boutique Hotel
Aerial view

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (654 reviews)
"Good front desk staff, welcoming breakfast staff, clean room and good area for walking to attractions. "
Canada
Reita
The price is ฿2,921
฿3,330 total
includes taxes & fees
31 Mar - 1 Apr
Grande Albergo Alfeo
Classic Room | View from room

Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (40 reviews)
"Nice kitchen area, centrally located."
United States
Richard
Gymnasium
Suite, Balcony, Sea View | Minibar, in-room safe, desk, soundproofing

Lakkios

Lakkios
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (64 reviews)
"Nice, central, clean, easy to park, quiet during the night, staff was welcoming, nice breakfast with view - excellent choice!"
Norway
Jon-Kåre
Lakkios
Porch

Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (375 reviews)
"The staff is extremely nice and friendly and you feel welcome. "
Canada
Florentina
Piccolo Hotel Casa Mia
Front of property

Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (274 reviews)
"Welcoming, room, staff and area around definitely stood out!"
Canada
Aina
The price is ฿1,969
฿2,245 total
includes taxes & fees
10 Mar - 11 Mar
Nostos rooms & Apartments
Superior Triple Room, Sea View | Terrace/patio

Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (27 reviews)
"Wonderful stay in the center of it all "
United States
lori
The price is ฿4,888
฿5,572 total
includes taxes & fees
21 Mar - 22 Mar
Fortaleza Charme House
Suite | Soundproofing, free WiFi

Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
8.8 out of 10, Excellent, (41 reviews)
"Good central location & nice breakfast selection "
Australia
Alan
The price is ฿5,637
฿6,426 total
includes taxes & fees
8 Mar - 9 Mar
Hotel Palazzo Cavalieri
Breakfast area

Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (126 reviews)
"Fantastic stay. Made to feel very welcome and what a lovely relaxing place to stay. Evening meal was exceptional. "
United States
Paul
The price is ฿7,495
฿8,544 total
includes taxes & fees
24 Mar - 25 Mar
Giuggiulena Villa
Exterior

Hotel Le Muse

Hotel Le Muse
3.0 star property
Santa Lucia
7.4 out of 10, Good, (71 reviews)
"All was great"
United States
deanne
The price is ฿4,736
฿5,399 total
includes taxes & fees
9 Mar - 10 Mar
Hotel Le Muse
View from room

Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (11 reviews)
"We had a lovely stay. Anna was very welcoming. We had a lovely large clean room and a nice modern bathroom. She went all out for breakfast. "
United States
Carl and Lina
Calafatari B&B
1 bedroom, down duvets, minibar, in-room safe

Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (57 reviews)
"Spacious room, dated but comfortable."
United States
Kenneth
The price is ฿10,695
฿12,135 total
includes taxes & fees
8 Mar - 9 Mar
Re Dionisio Luxury Suites
Triple Room, Balcony | Balcony

B&B Nike

B&B Nike
Santa Lucia
8.8 out of 10, Excellent, (75 reviews)
"Clean, good location. "
United States
Salvatore
B&B Nike
Exclusive Room | In-room safe, soundproofing, iron/ironing board, free WiFi

Isonzo Suites

Isonzo Suites
Santa Lucia
8.4 out of 10, Very good, (5 reviews)
"."
Italy
Gianluca
Isonzo Suites
Double Room | Premium bedding, desk, cots/infant beds, rollaway beds

B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (59 reviews)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is ฿2,682
฿3,058 total
includes taxes & fees
28 Mar - 29 Mar
B&B Siracusa
Exterior

AmaCasa Siracusa

AmaCasa Siracusa
Santa Lucia
10.0 out of 10, Exceptional, (1 review)
"Siamo stati molto bene, la struttura internamente è abbastanza ammodernata e l'accesso è stato"
Italy
Alessandro
The price is ฿3,030
฿3,454 total
includes taxes & fees
8 Mar - 9 Mar
AmaCasa Siracusa
Lobby lounge

Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (16 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
Regina Margherita
Free daily buffet breakfast

San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
9.2 out of 10, Wonderful, (5 reviews)
"Quarto bem decorado, um pouco apertado só tem lugar para uma mala. A reserva foi quarto de casal, mas nos colocaram em camas de solteiro, o problema era que o colchão escorregava. Eu reservei locais com elevador, muito antigo e tinha que subir com a mala por uns 10 degraus até o elevador.a equipe simpática e atenciosa, o café da manhã simples, mas de qualidade. Muito bonita a decoração dos espaços. A localização pelo app da expedia mostra outro endereço. Tivemos dificuldade de encontrar a...
Brazil
Paula
The price is ฿3,501
฿3,991 total
includes taxes & fees
12 Mar - 13 Mar
San Nicola Rooms Siracusa
Exterior

Agorà

Agorà
Santa Lucia
10.0 out of 10, Exceptional, (2 reviews)
"Trevligt, rent, bra service. Hade turen att få balkong. "
Sweden
Olof
The price is ฿3,097
฿3,531 total
includes taxes & fees
8 Mar - 9 Mar
Agorà
Comfort Triple Room, Balcony, Ocean View | View from room

Hotel Mediterraneo

Hotel Mediterraneo
3.0 star property
Santa Lucia
7.8 out of 10, Good, (123 reviews)
"Very friendly and helpful staff."
United States
David
Hotel Mediterraneo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.
Piazza del duomo - Siracusa

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

The Roman amphitheatre of Syracuse is one of the best preserved structures in the city of Syracuse, Sicily, from the early Imperial period. Between the arch and the amphitheatre, there was a monumental fountain, fed by a large cistern which has not yet been identified. A separate cistern provided water to the amphitheatre itself - it is preserved under the nearby church of San Nicola.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Ear of Dionysius and Archaeological Park of Neapolis.

Grotta degli innamorati - Kayak a Siracusa - Santa Panagia

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

UNA HOTELS One Siracusa

UNA HOTELS One Siracusa

10/10 Excellent
"Hotel was very good but was far from attractions. Dining options around the hotel were few and far between."
David 3-night trip
Posted 3 days ago
UNA HOTELS One Siracusa

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Lucia?
Based on Expedia customer reviews, Caportigia Boutique Hotel is the highest ranked property in Santa Lucia. This hotel offers a restaurant and free parking. Other top choices in the neighbourhood include Lakkios and La casa di Aneupe.
How many hotels will I find in Santa Lucia?
Expedia has 302 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.