Default HTG hotel image

Search Holiday Rentals in Santa Cruz

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
11 Sep - 13 Sep
In two months
23 Oct - 25 Oct
In three months
20 Nov - 22 Nov
In four months
18 Dec - 20 Dec

Our top choices for Santa Cruz holiday rentals

Deluxe Apartment, 1 Queen Bed with Sofa bed, Non Smoking, Kitchen | 1 bedroom, premium bedding, down duvets, in-room safe

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (292 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is ฿2,074
฿2,074 total
31 Aug - 1 Sept
Portal del Rodeo ApartaHotel - Arkadia Mall
Reception

2. Sites Hotel

Sites Hotel
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1,157 reviews)
"Excelente hotel."
United States
Fernanda
The price is ฿2,822
฿2,822 total
26 Sept - 27 Sept
Sites Hotel
Minibar, desk, laptop workspace, blackout curtains

3. Mali Experience

Mali Experience
3.0 star property
Rionegro
9.6 out of 10, Exceptional, (9 reviews)
"Perfect property ! Big enough. Big fridge, full kitchen; excellent bathroom and bed. The whole room is full little details and excellent design!"
United States
Jorge
The price is ฿2,852
฿2,852 total
10 Sept - 11 Sept
Mali Experience
Studio | View from room

4. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very good, (488 reviews)
"Good"
United States
Christian
The price is ฿3,499
฿3,499 total
3 Sept - 4 Sept
Travelers Rio Verde Living Suites
Lobby

5. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (725 reviews)
"Good place to had good vacations"
United States
Nicole
The price is ฿2,961
฿2,961 total
31 Aug - 1 Sept
Haven, A Design Hotel
Front of property

6. Seissta Medellin

Seissta Medellin
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (281 reviews)
"Great place to stay!"
United States
marcos
The price is ฿4,166
฿4,166 total
30 Aug - 31 Aug
Seissta Medellin
Restaurant

7. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (69 reviews)
"Awesome breakfast, great location. Great host"
United States
James
The price is ฿1,347
฿1,347 total
27 Sept - 28 Sept
Edificio Helena
Terrace/patio

8. Encanto Verde

Encanto Verde
2.5 star property
Marinilla
The price is ฿1,279
฿1,671 total
31 Aug - 1 Sept
Encanto Verde
Luxury Studio | In-room safe, desk, laptop workspace, soundproofing

9. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (128 reviews)
"Good choice, close to Poblado, good space, fully endowed"
United States
Jorge H
The price is ฿2,021
฿2,021 total
20 Sept - 21 Sept
Go Living and Suites by Jalo
Comfort Double Room | Premium bedding, down duvets, minibar, free WiFi

10. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (3 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is ฿795
฿795 total
26 Sept - 27 Sept
Hotel Moore 45
Elite Studio | In-room safe, blackout curtains, iron/ironing board (on request)

11. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (212 reviews)
"Great place.!"
United States
jeremy
The price is ฿2,163
฿2,163 total
27 Sept - 28 Sept
Origen Local Suites
Free daily full breakfast

12. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (102 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is ฿1,481
฿1,481 total
30 Aug - 31 Aug
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
Deluxe Suite, 2 Bedrooms, Mountain View | Premium bedding, down duvets, Select Comfort beds, minibar

13. Hotel Boutique Almaia 17 Near the Airport

Hotel Boutique Almaia 17 Near the Airport
3.0 star property
Rionegro
The price is ฿1,949
฿1,949 total
7 Sept - 8 Sept
Hotel Boutique Almaia 17 Near the Airport
Living area

14. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (43 reviews)
"Exelente servicio"
United States
Ernesto
The price is ฿1,973
฿2,474 total
9 Sept - 10 Sept
Skyline Ecoliving
1 bedroom, premium bedding, down duvets, free WiFi

15. Shabbat Hotel Boutique

Shabbat Hotel Boutique
4.0 star property
San Vicente
9.4 out of 10, Exceptional, (3 reviews)
"El jacuzzi no está protegido, se ensucia muy fácil con la lluvia y las hojas que caen de los árboles."
Colombia
Camilo
The price is ฿3,770
฿3,770 total
17 Sept - 18 Sept
Shabbat Hotel Boutique
Standard Apartment, 1 Double Bed | View from room

16. San Peter Suites

San Peter Suites
3.0 star property
Laureles
8.0 out of 10, Very good, (54 reviews)
"This ia a great place, super relaxed and friendly staff "
United States
Duncan
The price is ฿1,886
฿1,886 total
28 Aug - 29 Aug
San Peter Suites
Apartment (806) | Living area | 50-inch Smart TV with cable channels, TV

17. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very good, (450 reviews)
"Close to everything !"
United States
Marc
The price is ฿1,389
฿2,370 total
28 Aug - 29 Aug
Apartment Go Living & Suites by HOUSY HOST
Apartment, 3 Bedrooms | Terrace/patio

18. Wake Living

Wake Living
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (223 reviews)
"Great place"
United States
Pedro
The price is ฿6,402
฿6,402 total
31 Aug - 1 Sept
Wake Living
Deluxe Apartment #201 | 1 bedroom, premium bedding, pillow-top beds, in-room safe

19. Soul Lifestyle Apartments

Soul Lifestyle Apartments
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (146 reviews)
"We stayed there for 3 whole weeks and it was really nice. The location is just perfect, the space enough for a family of 4 and the attention and feedback from the front desk just perfect. We will stay there again."
United States
Edward
The price is ฿4,167
฿5,278 total
1 Sept - 2 Sept
Soul Lifestyle Apartments
Romantic Bungalow, Mountain View | Premium bedding, down duvets, desk, laptop workspace

20. Ancestral Glamping

Ancestral Glamping
2.0 star property
Barbosa
The price is ฿5,136
฿5,136 total
25 Sept - 26 Sept
Ancestral Glamping
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

Dann Carlton Medellin Hotel

Dann Carlton Medellin Hotel

10/10 Excellent
"Breakfast was good. Clean rooms Friendly staff"
Joel 4-night trip
Posted 8 hours ago
Dann Carlton Medellin Hotel

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a holiday rental in Santa Cruz?

Yes, there are holiday rentals close to the most popular sights in Santa Cruz, or you can select a more secluded option if you're looking for a relaxing stay.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the wider area, you’ll find University of Antioquia and Arvi Park.

What’s a holiday rental in Santa Cruz like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Santa Cruz. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can offer a sense of safety away from public hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also find more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a popular option for families.