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Check prices for these dates

Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Our top choices for Santa Clara holiday rentals

50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (162)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is ฿2,169
฿3,838 total
includes taxes & fees
2 Jan - 3 Jan 2026
Arcadia Condo Suites
Private beach
Habitación Privada en Playa Dorada + Kitchenette

Habitación Privada en Playa Dorada + Kitchenette

Habitación Privada en Playa Dorada + Kitchenette
3.0 star property
Vacamonte
The price is ฿679
฿1,046 total
includes taxes & fees
21 Dec - 22 Dec
Habitación Privada en Playa Dorada + Kitchenette
Interior detail
La Isabela Suites

La Isabela Suites

La Isabela Suites
3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (171)
"Wonderful charming property in the heart of the historic district. "
United States
Angela
La Isabela Suites
Restaurant
Las Clementinas

Las Clementinas

Las Clementinas
3.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (171)
"The front desk receptionist was extremely helpful! The room was clean and comfortable! We would definitely stay again!"
United States
april
The price is ฿5,073
฿5,580 total
includes taxes & fees
13 Jan - 14 Jan 2026
Las Clementinas
Exterior
Yoo Panamá by Boutique Apartments

Yoo Panamá by Boutique Apartments

Yoo Panamá by Boutique Apartments
3.5 star property
Bella Vista
8.2 out of 10, Very good, (49)
"Nice view & very clean"
United States
Latricia
The price is ฿1,085
฿5,563 total
includes taxes & fees
21 Dec - 22 Dec
Yoo Panamá by Boutique Apartments
Outdoor pool, free pool cabanas, pool loungers
Yoo Panama & Arts Tower

Yoo Panama & Arts Tower

Yoo Panama & Arts Tower
3.0 star property
Bella Vista
9.4 out of 10, Exceptional, (49)
"Nice stay"
United States
ANGEL
Yoo Panama & Arts Tower
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is ฿2,725
฿7,804 total
includes taxes & fees
21 Dec - 22 Dec
Wanders Panama by Boutique Apartments
Free WiFi, bed sheets
La Palma Aparta Suite

La Palma Aparta Suite

La Palma Aparta Suite
3.0 star property
Amador
The price is ฿1,490
฿2,582 total
includes taxes & fees
22 Dec - 23 Dec
La Palma Aparta Suite
Reception
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (483)
"The buffet bar and great customer service. "
United States
Kayhiuska
Torres de Alba Hotel & Suites
Outdoor pool
Boutique Apartments Panama

Boutique Apartments Panama

Boutique Apartments Panama
3.5 star property
Bella Vista
7.6 out of 10, Good, (220)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama
Outdoor pool
Boutique Apartments Atlapa

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
7.8 out of 10, Good, (27)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (55)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
Apartment (10D) | Balcony
San Francisco by Wynwood House

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is ฿4,696
฿5,952 total
includes taxes & fees
21 Dec - 22 Dec
San Francisco by Wynwood House
Apartment | Living area
Centriqo by Wynwood house

Centriqo by Wynwood house

Centriqo by Wynwood house
3.0 star property
Veracruz
The price is ฿5,149
฿6,701 total
includes taxes & fees
19 Jan - 20 Jan 2026
Centriqo by Wynwood house
Apartment, 1 Bedroom, Balcony | Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
Las Mañanitas
The price is ฿2,396
฿3,004 total
includes taxes & fees
25 Dec - 26 Dec
Swette Love 10 Minutes From the Airport Tocumen
Living area
Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
The price is ฿785
฿5,431 total
includes taxes & fees
22 Dec - 23 Dec
Living 73 Panamá by Boutique Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Clara Hotel Reviews

Megapolis Hotel Panamá

Megapolis Hotel Panamá

10/10 Excellent
"Amazing "
Latoya 5-night trip
Posted 1 day ago
Megapolis Hotel Panamá

Find out more about Santa Clara

Search for holiday rentals in Santa Clara on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Clara using one of the methods below:

  • View our selection of featured holiday rentals in Santa Clara
  • Use the map to find apartments and other holiday homes in the Santa Clara neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Clara while they last

Look no further and take a look at our great range of rental properties in Santa Clara!

Frequently asked questions

Can I find holiday rentals in Santa Clara?

Yes, there are holiday rentals close to the most popular sights in Santa Clara, or you can select a more secluded option if you're looking for a relaxing stay. Santa Clara is known for its monuments.

What can I see and do in Santa Clara?

While exploring the area, visit family-friendly sights like Summit Botanical Gardens & Zoo, or get outside and enjoy nature at Culebra Cut. In the wider area, you’ll find Albrook Shopping Mall and Gamboa Rainforest Resort.

What are holiday rentals like in Santa Clara?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Santa Clara. Holiday rentals offer extras like laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about cleanliness, holiday rentals can provide a sense of privacy away from shared hotel lifts and busy lobbies while still allowing you to travel. You'll also have more space in a holiday rental than in a standard hotel, which makes a holiday rental a popular option for a family trip or a small group gathering.