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Our top choices for Santa Ana hotels

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (73 reviews)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.4 out of 10, Good, (63 reviews)
"Excelente "
Mexico
David
Hostal La Cigarra

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (184 reviews)
"Super outdated. Looks dangerous in the area"
United States
Nina Kristine
Hotel República

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ฿1,717
฿2,744 total
includes taxes & fees
1 Mar - 2 Mar
La Manzana by Wynwood House

Panama House Bed & Breakfast

Panama House Bed & Breakfast
2.5 star property
Bella Vista, 4.6 km from Santa Ana
9.0 out of 10, Wonderful, (192 reviews)
"Amenities, staff, cleanliness, price all excellent!"
United States
Christopher
Panama House Bed & Breakfast

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.6 out of 10, Excellent, (1,006 reviews)
"Staff very friendly. Good breakfast. "
Canada
Liam
The price is ฿2,933
฿3,227 total
includes taxes & fees
1 Mar - 2 Mar
Hilton Garden Inn Panama City Downtown, Panama

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (296 reviews)
"The staff was super friendly "
United States
Anneliase
The price is ฿2,115
฿2,327 total
includes taxes & fees
24 Feb - 25 Feb
Ramada Panama Centro Via Argentina

Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG
4.0 star property
Bella Vista, 3.2 km from Santa Ana
8.0 out of 10, Very good, (223 reviews)
"Staff were amazing . Great breakfast and convenient area close to the train station "
United States
Darius
The price is ฿2,837
฿3,120 total
includes taxes & fees
22 Mar - 23 Mar
Crowne Plaza Panama by IHG

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 1.3 km from Santa Ana
7.6 out of 10, Good, (135 reviews)
"Place is convenient for local shopping local restaurants and access to train. The room is basic but not in a bad way it not luxury but it was clean and staff were all friendly I was there for a short stay and had no complaints. "
United States
James
The price is ฿881
฿969 total
includes taxes & fees
25 Feb - 26 Feb
Hotel Acapulco

Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (286 reviews)
"Amazing room, very spacious with a nice balcony, super clean, AC worked perfect, 10/10 everything. "
Canada
Anupam
Tantalo Hotel

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
8.8 out of 10, Excellent, (740 reviews)
"Very good spot for the price. Very close to everything. "
United States
Kartar
The price is ฿2,848
฿3,133 total
includes taxes & fees
1 Mar - 2 Mar
Toscana Inn

Hotel Vía España

Hotel Vía España
3.0 star property
Calidonia, 2.4 km from Santa Ana
6.2 out of 10, (177 reviews)
"Don’t stay there it’s the "
United States
Andreas
Hotel Vía España

Hotel Marparaiso

Hotel Marparaiso
3.0 star property
Calidonia, 1.7 km from Santa Ana
7.8 out of 10, Good, (165 reviews)
"I love the hotel and ever thing about it ,location transport, safe around the hotle ."
United States
Andres
The price is ฿1,131
฿1,244 total
includes taxes & fees
15 Mar - 16 Mar
Hotel Marparaiso

Hotel Latino

Hotel Latino
3.0 star property
Calidonia, 1.8 km from Santa Ana
6.6 out of 10, (232 reviews)
"Staff at front desk was very unprofessional and disrespectful. For some reason they had trouble finding my reservation after repeatedly telling them all the information. Three different people at the desk looked through their system and couldn’t find it while I spent over 30 minutes standing there. They kept sending me away telling me I was at the wrong place. While showing them even the hotel’s picture and address. Another reason why I wouldn’t really recommend the place for people touring as...
United States
Evelyn Vanessa
Hotel Latino

Hotel Montreal

Hotel Montreal
3.5 star property
Bella Vista, 2.7 km from Santa Ana
6.0 out of 10, (405 reviews)
"The hotel was as I expected. Nothing fancy but clean, comfortable, with easy access from the city. There was parking always available. The restaurant, bar, and the pool were open. The people who worked there had the best predisposition to help and make our time in the hotel great. "
United States
Maria Eugenia Fourcade
Hotel Montreal

Canova

Canova
3.0 star property
Calidonia, 1.4 km from Santa Ana
8.2 out of 10, Very good, (147 reviews)
"Very close place to everything. Very affordable. "
United States
Alex
The price is ฿889
฿978 total
includes taxes & fees
22 Mar - 23 Mar
Canova

Taboga Palace Spa Hotel

Taboga Palace Spa Hotel
3.5 star property
17.7 km from Santa Ana
9.2 out of 10, Wonderful, (45 reviews)
"David and his wife provide a truly fantastic at such a quaint and beautiful property. The pool and views are incredible. We are having such a great time and plan to return in the future."
Canada
Marc-Andre
The price is ฿4,044
฿4,448 total
includes taxes & fees
24 Feb - 25 Feb
Taboga Palace Spa Hotel

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 1.8 km from Santa Ana
7.8 out of 10, Good, (115 reviews)
"Great spot for the price "
United States
frank
Hotel Pension Corona

La Résidence Panamá

La Résidence Panamá
2.5 star property
Campo Alegre, 3.4 km from Santa Ana
9.0 out of 10, Wonderful, (6 reviews)
"EL hotel es nuevo, todo muy lindo. La habitación que me tocó era muy cómoda, pero con solo una pequeña ventana a una zona de servicios... no muy lindo... unica observación El personal sumamente amable"
Mexico
JOAQUIN
The price is ฿4,031
฿4,434 total
includes taxes & fees
28 Feb - 1 Mar
La Résidence Panamá

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.8 out of 10, Excellent, (509 reviews)
"Excellent place, friendly staff, great breakfast and many shops close by. "
United States
Raymond
Torres de Alba Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 88 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.