Search Hotels in Santa Ana, Panama City

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Ana hotels

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (94 reviews)
"yes there was laundryroom, iron and nice pool. the stay was very good"
United States
melvin
The price is ฿2,744
฿3,998 total
includes taxes & fees
29 May - 30 May
Casco View Apartments

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (71 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is ฿1,016
฿1,117 total
includes taxes & fees
26 May - 27 May
Hostal La Cigarra

La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.4 out of 10, Good, (17 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is ฿2,305
฿3,434 total
includes taxes & fees
25 May - 26 May
La Manzana Barrio Vivo by Wynwood

Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (194 reviews)
"It's meant for a short stay, close to Casco Viejo and coast line. Clean bed and bathroom. Needs some maintenance. Beware, there's no hot water if that's a deal breaker for you."
United States
Mario
The price is ฿956
฿3,012 total
includes taxes & fees
25 May - 26 May
Hotel República

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel

Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
Hotel Riazor

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.6 out of 10, Excellent, (2,550 reviews)
"Great place to stay, restaurant is great also"
United States
Janet
The price is ฿4,280
฿4,924 total
includes taxes & fees
15 Jun - 16 Jun
Crowne Plaza Panama Airport by IHG

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.4 out of 10, Very good, (1,827 reviews)
"This hotel is very clean and the Staff are very friendly."
United States
Doreen
The price is ฿3,573
฿3,930 total
includes taxes & fees
18 Jun - 19 Jun
Riande Aeropuerto Hotel & Casino

Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
8.8 out of 10, Excellent, (937 reviews)
"Breakfast was great, rooms very clean"
United States
juanita
The price is ฿1,911
฿3,360 total
includes taxes & fees
25 May - 26 May
Waymore Hotel Spa & Casino

ORHO Hotel Boutique 15 Minutes from PTY Airport

ORHO Hotel Boutique 15 Minutes from PTY Airport
2.0 star property
20.5 km from Santa Ana
8.8 out of 10, Excellent, (128 reviews)
"Lovely property, staff was always smiling and it's close to restaurants."
United States
Luis
The price is ฿3,713
฿4,819 total
includes taxes & fees
25 May - 26 May
ORHO Hotel Boutique 15 Minutes from PTY Airport

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.7 km from Santa Ana
9.0 out of 10, Wonderful, (1,001 reviews)
"Great service, very comfortable beds, truly excellent breakfast manager and staff. "
United States
Elizabeth
The price is ฿3,561
฿3,917 total
includes taxes & fees
30 May - 31 May
Courtyard by Marriott Panama Metromall

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.6 out of 10, Excellent, (1,003 reviews)
"Excellent location, good parking."
United States
Mark
The price is ฿2,949
฿3,244 total
includes taxes & fees
4 Jun - 5 Jun
Radisson Hotel Panama Canal

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco, 5.7 km from Santa Ana
8.6 out of 10, Excellent, (1,006 reviews)
"Very well maintained and beautiful place."
United States
Simon
The price is ฿4,138
฿4,552 total
includes taxes & fees
29 May - 30 May
Sheraton Grand Panama

Villa Caprichosa

Villa Caprichosa
2.5 star property
18.3 km from Santa Ana
9.8 out of 10, Exceptional, (71 reviews)
"Really good food, nice staff it was the best service! "
United States
junier
The price is ฿4,443
฿4,888 total
includes taxes & fees
25 May - 26 May
Villa Caprichosa

The Beach House

The Beach House
3.0 star property
Amador, 4.8 km from Santa Ana
8.4 out of 10, Very good, (432 reviews)
"Everting was clean and good nice place to stay "
United States
Kristine
The price is ฿2,430
฿2,673 total
includes taxes & fees
25 May - 26 May
The Beach House

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.2 out of 10, Wonderful, (292 reviews)
"Very good place to stay and safe place..!"
United States
Somnueg
The price is ฿3,921
฿4,528 total
includes taxes & fees
28 May - 29 May
Arcadia Condo Suites

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,156 reviews)
"great breakfast, great staff"
United States
Eduardo
The price is ฿3,374
฿3,711 total
includes taxes & fees
19 Jun - 20 Jun
Plaza Paitilla Inn Hotel

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (695 reviews)
"Breakfast was exceptional, everything you could think of was available. The spa was great and the staff 10/10"
United States
Aeon
The price is ฿7,572
฿8,329 total
includes taxes & fees
5 Jun - 6 Jun
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Albrook Inn

Albrook Inn
3.0 star property
3.3 km from Santa Ana
7.8 out of 10, Good, (610 reviews)
"Wonderful staff and very clean rooms. I really enjoy staying here."
United States
Stacy
The price is ฿2,085
฿2,294 total
includes taxes & fees
27 May - 28 May
Albrook Inn

The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,115 reviews)
"It was a nice stay and breakfast is delicious"
United States
Susana
The price is ฿2,744
฿3,019 total
includes taxes & fees
13 Jun - 14 Jun
The Executive Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments
3.5 star property
9.0
Wonderful
94 reviews
View
Bar (on property)
Hostal La Cigarra
2.0 star property
7.6
Good
71 reviews
View
Apartment (20) | Iron/ironing board, free WiFi, bed sheets
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.4
Good
17 reviews
View
Double Room | View from room
Hotel República
2.0 star property
6.8
194 reviews
View
Front of property
ART CASCO The Hotel
2.0 star property
6.0
11 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Estación Lotería or Santo Tomas Station to explore sights like Via Espana.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Casco View Apartments is one of the top choices for your stay in Santa Ana. This condo is a short 8-minute walk from Avenida Balboa, and it offers an outdoor pool and in-room kitchens.
How many hotels can I expect to find in Santa Ana?
Expedia has 117 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.