A white colonial church with ornate architecture and a large wooden door.

Search Hotels in Santa Ana, Antigua Guatemala

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

1. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ฿1,598
฿1,949 total
includes taxes & fees
2 Nov - 3 Nov
Hostal Casa Buho
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

2. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
Villas Santa Ana-Ricardo
A rooftop with a red roof, a white railing, and a view of a mountainous landscape.

3. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ฿446
฿953 total
includes taxes & fees
6 Oct - 7 Oct
Castillo De Los Gigantes
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

4. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,168 reviews)
"Outstanding staff and the hotel was beautiful"
United States
Mario
The price is ฿8,272
฿10,502 total
includes taxes & fees
6 Oct - 7 Oct
Hotel Museo Spa Casa Santo Domingo
A restaurant with a brick wall, wine racks, and tables set for dining.

5. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Great breakfast."
Canada
Harvey
The price is ฿5,147
฿6,481 total
includes taxes & fees
27 Oct - 28 Oct
Los Pasos Boutique Hotel & Spa
A covered corridor with tiled flooring, potted plants, and a wooden bench.

6. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (807 reviews)
"Hotel was conveniently located. But the walls were really thin. We were in front of the restaurant and the main hall so you can hear EVERYTHING and Everyone. Overall ok hotel and convenient location."
United States
Erika
The price is ฿3,624
฿4,422 total
includes taxes & fees
19 Oct - 20 Oct
Hotel Las Farolas
A corner with two upholstered chairs, a small round table, and a potted plant.

7. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (461 reviews)
"Great hospitality"
United States
abdessamad
The price is ฿2,847
฿3,473 total
includes taxes & fees
6 Oct - 7 Oct
Ciel-Luxe Hotels
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

8. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"I loved my stay will be back my next time around"
United States
LESLIE A
The price is ฿5,414
฿6,605 total
includes taxes & fees
6 Oct - 7 Oct
Porta Hotel Antigua
A garden pathway leading to a building with a green lawn and a clear blue sky.

9. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,001 reviews)
"It is a beautiful and quiet hotel. Perfect place for families."
United States
Johanna Elizabeth
The price is ฿4,081
฿4,979 total
includes taxes & fees
6 Oct - 7 Oct
Hotel Soleil La Antigua
A cozy room with a round table, striped armchairs, and a potted plant.

10. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Very clean room staff was very helpful with accommodations and I would come back again"
United States
Simon
The price is ฿6,343
฿8,577 total
includes taxes & fees
7 Oct - 8 Oct
Hotel Camino Real Antigua
A building with a covered patio area, a garden with various plants, and a hanging vine with purple flowers.

11. Hotel Aurora

Hotel Aurora
3.5 star property
Historic Center, 1.1 km from Santa Ana
9.6 out of 10, Exceptional, (428 reviews)
"Very close to everything, clean and beautiful"
United States
Mariceliz
The price is ฿2,391
฿2,917 total
includes taxes & fees
28 Oct - 29 Oct
Hotel Aurora
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

12. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (931 reviews)
"Great breakfast and room service, affordable spa"
United States
Keishawn
The price is ฿2,651
฿3,234 total
includes taxes & fees
7 Oct - 8 Oct
El Carmen Hotel
A stone building with arched entrances and a balcony with wrought iron railings.

13. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (507 reviews)
"Great place to stay"
United States
Mauricio
The price is ฿3,515
฿4,289 total
includes taxes & fees
27 Oct - 28 Oct
Meson Panza Verde
A courtyard with stone walls, a fountain, and various plants and flowers.

14. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (785 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ฿8,390
฿10,236 total
includes taxes & fees
6 Oct - 7 Oct
Hotel Posada de Don Rodrigo Antigua
An outdoor patio with stone flooring, wicker furniture, and umbrellas providing shade.

15. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (370 reviews)
"Great location, very friendly staff and very clean."
United States
Martha
The price is ฿1,359
฿1,658 total
includes taxes & fees
13 Oct - 14 Oct
Hotel Casa Carmina by AHS
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

16. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (250 reviews)
"The staff was very friendly and the room and surrounding property were very pretty and clean"
United States
Logan
The price is ฿2,866
฿3,496 total
includes taxes & fees
6 Oct - 7 Oct
Casa Noble Hotel
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

17. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (495 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ฿5,942
฿7,349 total
includes taxes & fees
6 Oct - 7 Oct
San Rafael Hotel
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

18. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (280 reviews)
"Beautiful rooms, very attentive staff, and delicious breakfast!"
United States
Miria
The price is ฿6,418
฿7,830 total
includes taxes & fees
6 Oct - 7 Oct
Las Cruces Boutique Hotel
A covered walkway with wooden pillars and tropical plants.

19. Good Hotel Antigua Guatemala, a Member of Design Hotels

Good Hotel Antigua Guatemala, a Member of Design Hotels
4.0 star property
0.8 km from Santa Ana
9.2 out of 10, Wonderful, (570 reviews)
"What a fantastic place to stay. Everything that I expected and excellent service."
United States
Luz Adriana
The price is ฿6,590
฿8,040 total
includes taxes & fees
6 Oct - 7 Oct
Good Hotel Antigua Guatemala, a Member of Design Hotels
A multi-level outdoor garden with potted plants and a wooden pergola structure.

20. Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (498 reviews)
"Great Service and breakfasts …"
United States
GIOVANNI
The price is ฿2,926
฿3,570 total
includes taxes & fees
6 Oct - 7 Oct
Naif Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Hyatt Centric Guatemala City

Hyatt Centric Guatemala City

10/10 Excellent
"Great hotel! Location is great, very clean, modern, staff is so helpful. Would stay at the hotel is I visit Guatemala again."
Carlos 2-night trip
Posted 2 hours ago
Hyatt Centric Guatemala City

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on our traveller data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.