Search Hotels in Santa Ana, Antigua Guatemala

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Ana hotels

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.8 out of 10, Excellent, (15 reviews)
"We really enjoyed our stay. Beautifully decorated and plenty of space for our family. Venders selling food at night right outside villa makes a nice option for dinner."
United States
Santiago Morales
The price is ฿4,132
฿5,042 total
includes taxes & fees
10 May - 11 May
Villas Santa Ana-Ricardo

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.8 out of 10, Excellent, (25 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ฿1,223
฿1,492 total
includes taxes & fees
1 Jun - 2 Jun
Hostal Casa Buho

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (52 reviews)
"Beautiful hotel with clean rooms and friendly staff. The only downsides are the distance to the center (a 30-minute walk) and the chickens and peacocks screaming early in the morning"
United States
Patrick
The price is ฿1,477
฿1,802 total
includes taxes & fees
1 Jun - 2 Jun
Casa Buho B&B

La guarida del caudillo

La guarida del caudillo
1.0 star property
Santa Ana
The price is ฿893
฿1,089 total
includes taxes & fees
22 May - 23 May
La guarida del caudillo

Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ฿475
฿973 total
includes taxes & fees
9 May - 10 May
Castillo De Los Gigantes

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
20.1 km from Santa Ana
9.2 out of 10, Wonderful, (1,015 reviews)
"Great food, rooms are clean!!"
United States
Rossana
The price is ฿3,649
฿4,452 total
includes taxes & fees
10 May - 11 May
Tikal Futura Hotel & Convention Center

Le Suisse Spa

Le Suisse Spa
3.0 star property
6.8 km from Santa Ana
8.2 out of 10, Very good, (26 reviews)
"Temperatures of pools and spa was wonderful! Staff was very friendly. I enjoyed the food at the restaurant. The tortilla soup was especially delicious. Also had a Michelada that was one of the best I’ve ever had! "
United States
Karen
The price is ฿2,922
฿3,565 total
includes taxes & fees
15 May - 16 May
Le Suisse Spa

Kawilal Hotel

Kawilal Hotel
3.5 star property
13.9 km from Santa Ana
9.0 out of 10, Wonderful, (142 reviews)
"Great place to spend some family vacations. Good staff, really good breakfast option. The food (lunch and dinner) a little bit expensive."
United States
David
The price is ฿3,770
฿4,599 total
includes taxes & fees
26 May - 27 May
Kawilal Hotel

AC Hotel by Marriott Guatemala City

AC Hotel by Marriott Guatemala City
4.0 star property
26.4 km from Santa Ana
8.6 out of 10, Excellent, (1,004 reviews)
"Best Hotel in Guatemala City! The food was very delicious and rooms are very clean."
United States
Manuel
The price is ฿3,807
฿4,645 total
includes taxes & fees
23 May - 24 May
AC Hotel by Marriott Guatemala City

Mestizo Cortijo

Mestizo Cortijo
3.0 star property
4.3 km from Santa Ana
8.8 out of 10, Excellent, (129 reviews)
"It was a great stay, the place is absolutely breath taking and the staff are very sweet. "
United States
Perla
The price is ฿3,830
฿4,672 total
includes taxes & fees
10 May - 11 May
Mestizo Cortijo

La Capitania de San Pedro

La Capitania de San Pedro
2.5 star property
2.9 km from Santa Ana
8.8 out of 10, Excellent, (25 reviews)
"Very nice hotel, nice people "
United States
leonel
The price is ฿2,372
฿2,893 total
includes taxes & fees
12 May - 13 May
La Capitania de San Pedro

Casa Aurora

Casa Aurora
3.0 star property
20.9 km from Santa Ana
8.8 out of 10, Excellent, (185 reviews)
"Breakfast was great, very frendly staff."
United States
Marlon
The price is ฿1,480
฿1,805 total
includes taxes & fees
10 May - 11 May
Casa Aurora

Hilton Guatemala City

Hilton Guatemala City
4.5 star property
25.9 km from Santa Ana
8.6 out of 10, Excellent, (711 reviews)
"Everything was good "
United States
Elmer
The price is ฿3,539
฿4,317 total
includes taxes & fees
17 May - 18 May
Hilton Guatemala City

L Aurora Inn

L Aurora Inn
3.0 star property
21 km from Santa Ana
9.0 out of 10, Wonderful, (138 reviews)
"Comfortable room, very close to the airport, and a nice breakfast"
United Kingdom
ANITA
The price is ฿2,699
฿3,292 total
includes taxes & fees
23 May - 24 May
L Aurora Inn

In & Out Hotel

In & Out Hotel
3.0 star property
20.9 km from Santa Ana
8.6 out of 10, Excellent, (859 reviews)
"Nice clean room and close to the airport "
Canada
Alyssa
The price is ฿1,571
฿1,916 total
includes taxes & fees
11 May - 12 May
In & Out Hotel

Good Hotel Guatemala City

Good Hotel Guatemala City
3.0 star property
23.9 km from Santa Ana
9.4 out of 10, Exceptional, (331 reviews)
"Nice place to stay in Guatemala City."
United States
Shane
The price is ฿3,114
฿3,799 total
includes taxes & fees
24 May - 25 May
Good Hotel Guatemala City

Casa Carmel Bed and Breakfast

Casa Carmel Bed and Breakfast
3.0 star property
24.2 km from Santa Ana
9.6 out of 10, Exceptional, (129 reviews)
"Loved the breakfast! Great period house built in the 1930s, located in the historic district."
United States
Sudhir
The price is ฿1,856
฿2,264 total
includes taxes & fees
11 May - 12 May
Casa Carmel Bed and Breakfast

Hotel Vista Quince

Hotel Vista Quince
5.0 star property
25.5 km from Santa Ana
8.6 out of 10, Excellent, (263 reviews)
"We really enjoyed our stay, everything was great- we will be returning "
United States
Lucy
The price is ฿4,060
฿4,953 total
includes taxes & fees
10 May - 11 May
Hotel Vista Quince

Barceló Guatemala City

Barceló Guatemala City
4.5 star property
22.7 km from Santa Ana
9.2 out of 10, Wonderful, (3,322 reviews)
"great hotel, good location."
United States
emma
The price is ฿3,709
฿4,525 total
includes taxes & fees
8 Jun - 9 Jun
Barceló Guatemala City

Hostal los Volcanes ciudad de Guatemala

Hostal los Volcanes ciudad de Guatemala
3.0 star property
21.1 km from Santa Ana
8.6 out of 10, Excellent, (79 reviews)
"The staff was great thanks "
United States
Erik
The price is ฿1,018
฿2,225 total
includes taxes & fees
9 May - 10 May
Hostal los Volcanes ciudad de Guatemala
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on our traveller data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 14 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.