San Francisco Packages (Flight + Hotel)
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ฿27,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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Where to stay in San Francisco
Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
Casco Viejo
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Bella Vista
1 out of top 10 points of interest in this area
Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.
El Cangrejo
The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Felipe
While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.
Calidonia
2 out of top 10 points of interest in this area
Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Lotería Station or Santo Tomás Station to explore sights like Via Espana.
Top hotels in San Francisco
Megapolis Hotel Panamá
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
฿5,291
฿5,820 total
29 Sept - 30 Sept
includes taxes & fees
8.6/10 Excellent! (1,743 reviews)
"Deben mejorar el servicio de atención de parte de su personal de recepción y desayuno"
Reviewed on 21 Sept 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco Panama City Panama
฿3,274
฿3,602 total
3 Oct - 4 Oct
includes taxes & fees
9.6/10 Exceptional! (1,347 reviews)
"I requested late check out when I checked in. We agreed on a set time. I was called twice during the extended time and housekeeping attempted to enter between those calls. Their communication is poor and the staff were hardly apologetic, except for the housekeeper. Evidently a notation for late check ..."
Reviewed on 21 Sept 2026
Decapolis Hotel Panama City
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
฿3,642
฿4,006 total
10 Oct - 11 Oct
includes taxes & fees
8.6/10 Excellent! (1,721 reviews)
"Very nice"
Reviewed on 21 Sept 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a San Francisco holiday package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built holiday package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco holiday package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes travelling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Centre. Ph Boutique Quartier Atlapa or New Cosy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travellers.
How far in advance should I book my San Francisco holiday?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco holiday looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia holiday package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco holiday package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco holiday package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.
Stay near popular San Francisco attractions
Multiplaza Pacific Mall
9.0/10 (4,497 reviews)
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Via Espana
8.4/10 (2,902 reviews)
During your trip to Panama City, you can browse for the perfect souvenirs at Via Espana. Stroll along the seaside or visit the casinos in this vibrant area.
ATLAPA Conventions Center
7.6/10 (31 reviews)
Learn about the events happening in ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area or visit its top-notch restaurants.
Multicentro Panama
8.2/10 (274 reviews)
During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.
Pacific Center
You can browse for the perfect souvenirs at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.
Omar Torrijos Recreational Park
5.6/10 (4 reviews)
Omar Torrijos Recreational Park is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's seaside and enjoy its lively bars.
Things to do
Panama: Monkey and Sloth Jungle Habitat Panama Tour
฿1,378
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
฿1,053
per adult
100% of travellers recommend
Transfer to Panama Canal (Miraflores Locks)
฿459
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.