Search Hotels in San Antonio, San Miguelito

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21 Dec - 22 Dec
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22 Dec - 23 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for San Antonio hotels

Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
12.5 km from San Antonio
8.4 out of 10, Very good, (1292)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is ฿4,117
฿4,529 total
includes taxes & fees
22 Dec - 23 Dec
Megapolis Hotel Panamá
Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
5.7 km from San Antonio
9.0 out of 10, Wonderful, (37)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is ฿3,769
฿4,146 total
includes taxes & fees
22 Dec - 23 Dec
ORHO HOTEL BOUTIQUE PANAMA Airport
Outdoor pool, pool loungers
Gran Evenia Panama

Gran Evenia Panama

Gran Evenia Panama
4.5 star property
12.4 km from San Antonio
9.2 out of 10, Wonderful, (195)
"The property was conveniently located near shops, restaurants and casinos. The food at breakfast was good. Although the pancakes could be better. "
United States
Nicole
Gran Evenia Panama
47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
15.8 km from San Antonio
9.0 out of 10, Wonderful, (1009)
"Excellent hotel , good breakfast, great location, would highly recommend "
United States
Glen
The price is ฿6,656
฿7,321 total
includes taxes & fees
22 Dec - 23 Dec
Central Hotel Panama Casco Viejo
Meeting facility
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
11.9 km from San Antonio
8.8 out of 10, Excellent, (1001)
"Everything was clean and the staff was very cooperative."
United States
Deangelo
The price is ฿4,994
฿5,493 total
includes taxes & fees
3 Jan - 4 Jan 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
23.4 km from San Antonio
8.0 out of 10, Very good, (1002)
"Great place and location, excellent food choices! "
United States
Francisco
The price is ฿7,159
฿7,874 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Westin Playa Bonita Panama
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
15.8 km from San Antonio
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is ฿10,118
฿11,130 total
includes taxes & fees
23 Dec - 24 Dec
Hotel La Compañía Casco Antiguo
Exterior
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
4.0 star property
12.8 km from San Antonio
7.8 out of 10, Good, (1006)
"Great service and staff. "
United States
Roberto
The price is ฿3,251
฿3,576 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
4 km from San Antonio
9.6 out of 10, Exceptional, (641)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ฿7,043
฿7,748 total
includes taxes & fees
17 Jan - 18 Jan 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Outdoor pool
Hilton Panama

Hilton Panama

Hilton Panama
5.0 star property
13 km from San Antonio
8.8 out of 10, Excellent, (1001)
"Nice room! Clean. Nice balcony, "
United States
Cassandra
The price is ฿6,603
฿7,263 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Panama
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento, 1.4 km from San Antonio
8.8 out of 10, Excellent, (1002)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is ฿3,177
฿3,495 total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott Panama Metromall
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
15.7 km from San Antonio
9.8 out of 10, Exceptional, (560)
"Great hotel and location "
United Kingdom
Russell
The price is ฿12,014
฿13,215 total
includes taxes & fees
12 Jan - 13 Jan 2026
Sofitel Legend Casco Viejo, Panama City
Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
12.4 km from San Antonio
9.0 out of 10, Wonderful, (4697)
"Awesome great place to stay "
United States
Herbert
The price is ฿3,435
฿3,778 total
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Riu Plaza Panama
Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
6.1 km from San Antonio
8.4 out of 10, Very good, (2322)
"Spacious room, clean, good breakfast "
United States
Juan
The price is ฿3,455
฿3,800 total
includes taxes & fees
24 Dec - 25 Dec
Crowne Plaza Panama Airport by IHG
Breakfast and dinner served, international cuisine
Amarla Boutique Hotel Casco Viejo

Amarla Boutique Hotel Casco Viejo

Amarla Boutique Hotel Casco Viejo
3.0 star property
15.8 km from San Antonio
9.6 out of 10, Exceptional, (106)
"Great little hotel in Casco Viejo. Rooms are small, but comfortable. Reception is a bit odd, but service was nice. "
United States
Frederick
Amarla Boutique Hotel Casco Viejo
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
12.5 km from San Antonio
8.6 out of 10, Excellent, (1456)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is ฿4,317
฿4,749 total
includes taxes & fees
22 Dec - 23 Dec
Decapolis Hotel Panama City
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
12.8 km from San Antonio
10.0 out of 10, Exceptional, (126)
"Great hotel fair price"
United States
Santiago
The price is ฿4,923
฿5,416 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hyatt Regency Panama City
Outdoor pool
MARINN PLACE Financial District

MARINN PLACE Financial District

MARINN PLACE Financial District
3.5 star property
12.8 km from San Antonio
9.2 out of 10, Wonderful, (299)
"Second stay, very nice"
Canada
Xiaozhi
The price is ฿3,518
฿3,869 total
includes taxes & fees
22 Dec - 23 Dec
MARINN PLACE Financial District
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
6.2 km from San Antonio
9.4 out of 10, Exceptional, (162)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is ฿2,261
฿3,939 total
includes taxes & fees
3 Jan - 4 Jan 2026
Arcadia Condo Suites
Couples treatment room(s), sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
12.8 km from San Antonio
9.4 out of 10, Exceptional, (1000)
"Great staff, super accommodating. Best place to stay in Panama!"
United States
Sebastian
The price is ฿6,300
฿6,930 total
includes taxes & fees
14 Jan - 15 Jan 2026
Bristol Panama, a Registry Collection Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in San Antonio

Find the best San Antonio areas for the activities you enjoy most.

Cerro Viento

Shopping and restaurants are notable features of Cerro Viento. You might consider stopping by Metromall Panama while you're exploring the neighbourhood.

José Domingo Espinar

José Domingo Espinar might not have many top sights, but Estadio Rommel Fernandez and Metromall Panama are two attractions nearby that you can check out.

Rufina Alfaro

Rufina Alfaro might not have many top sights, but Metromall Panama and Los Pueblos Commercial Center are two attractions nearby that you can check out.

Victoriano Lorenzo

If you're looking for some top things to see and do in Victoriano Lorenzo and surrounding area, you can visit Panama Viejo and Estadio Rommel Fernandez.

Amelia Denis de Icaza

While there might not be top attractions in Amelia Denis de Icaza, you can explore the larger area and discover places like El Dorado Mall and Panama Viejo.

Top San Antonio Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"No worries. Outstanding in every aspects. Room, food, personnel, pool, location. "
siany Gordon 3-night trip
Posted 13 hours ago
Hotel Riu Plaza Panama

Frequently asked questions

What's it like in San Antonio?
San Antonio is a neighbourhood that travellers like for its shopping and gardens.
If I need to cancel my hotel reservation in San Antonio, will I receive a refund?
Yes, most hotel reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best options available in San Antonio.
What is there to do in this San Miguelito neighbourhood?
Metromall Panama, Los Pueblos Commercial Center and Estadio Rommel Fernandez are just a few of the places to visit in and around San Antonio. While you're out sightseeing, Plaza de Francia and Atrio Mall are a couple of additional sights to visit in San Miguelito.