San Antonio Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ฿4,531 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Where to stay in San Antonio

Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio
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Rufina Alfaro

Rufina Alfaro might not have many top sights, but Metromall Panama and Los Pueblos Commercial Center are two attractions nearby that you can check out.

Find hotels in Rufina Alfaro

Top hotels in San Antonio

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ฿3,700 per night from 5 Nov to 6 Nov
฿3,700
฿4,070 total
5 Nov - 6 Nov
includes taxes & fees
9/10 Wonderful! (4,469 reviews)
Great choices of Latin and European food options.

Reviewed on 3 Nov 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
The price is ฿4,009 per night from 4 Dec to 5 Dec
฿4,009
฿4,410 total
4 Dec - 5 Dec
includes taxes & fees
8.4/10 Very Good! (2,292 reviews)
Everything went smoothly. Room was more than i expected

Reviewed on 3 Nov 2025

Crowne Plaza Panama Airport by IHG
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is ฿4,043 per night from 16 Nov to 17 Nov
฿4,043
฿4,447 total
16 Nov - 17 Nov
includes taxes & fees
8.4/10 Very Good! (1,174 reviews)
Room was excellent

Reviewed on 2 Nov 2025

Megapolis Hotel Panamá
See all 1,536 properties in San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Antonio holiday package cost?
Choose from any combination of car rentals, flights and hotels, and you can be holidaying in San Antonio from just . And the more you bundle, the more cash you save. The holiday of your dreams has never been more affordable.
How do I get a cheap travel package to San Antonio?
Our San Antonio holiday packages promise plenty of savings for the savvy traveller. For the best deal, simply combine your flights, hotels and extras (including tours) into one neat package. But great bargains are only the start of your next unforgettable adventure. Book with Expedia and and you'll have over 550 airlines and 1,000,000 hotel options across the globe to pick from. Whatever your budget or style, there's a holiday package that's perfect for you.
Where should I stay in San Antonio?
If you're interested in visiting Metromall Panama, give commuting a miss and book a hotel nearby. It's one of the best attractions in this neighbourhood.
What are the top hotels in San Antonio?
Dumas Villas is one of San Antonio's most popular properties. Lock in a room here and you'll slumber peacefully knowing you're in capable hands.
How far in advance should I book my San Antonio holiday?
Search Expedia to compare international airfares ASAP. You can usually purchase a seat up to 12 months in advance. If you can't see your preferred air carrier, or you've left things to the last minute, don't stress. Cheap fares to San Antonio sometimes occur within weeks of the date of departure.
What does an Expedia San Antonio travel package include?
From airfares and hotels to rental cars, Expedia can help you put together a San Antonio package that's right for you. Holidaying for a few weeks? Check out a rental car, flight and hotel bundle. If your break is short, a hotel and flight deal may be more your style. Experiences can also be added once you've made your booking. Our holiday packages make it a cinch to plan and save.
What should I know before booking a San Antonio travel package?
So many places to explore, so many things to do. With a package, you can check more of them off your list. Bundle your hotels, flights and rental cars and get set to save.
Can I choose my airline with a San Antonio Expedia holiday package?
Yes — that's the beauty of an Expedia holiday package. You're in control. We have more than 550 airline partners all over the world, so you have lots of choice when putting together your San Antonio getaway.
If I'm not able to travel, can I cancel my San Antonio holiday package?
We totally get it — unexpected stuff happens. If you've booked a San Antonio holiday package and need to cancel or amend it, we can help. We recommend browsing our Customer Service Portal first for information. But generally, if you've booked your package within 24 hours, you may be able to cancel or amend your itinerary for free. If it's been longer than 24 hours, your hotel, airline or car rental company may impose a fee.

Things to do

Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

฿1,635
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

฿1,049
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Panama City: Poin Full Package Experience

Panama City: Poin Full Package Experience

฿5,067
per adult
90% of travellers recommend
Panama City: Poin Full Package Experience
See all activities in San Miguelito
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.