Mississippi County Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

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  • Better together

    Save up to ฿27,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Top hotels in Mississippi County

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
The price is ฿2,004 per night from 1 Jun to 2 Jun
฿2,004
฿2,224 total
1 Jun - 2 Jun
includes taxes & fees
6.8/10 (631 reviews)
Property is in terrible condition, staff was short with us and refused to give a refund on the room when we were not happy with the condition of the hotel. Would not stay.

Reviewed on 3 May 2026

Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Fully refundableReserve now, pay when you stay
The price is ฿2,428 per night from 7 May to 8 May
฿2,428
฿2,695 total
7 May - 8 May
includes taxes & fees
6.8/10 (412 reviews)
Coffee

Reviewed on 22 Apr 2026

The Riverstone Hotel Charleston-Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is ฿3,594 per night from 17 May to 18 May
฿3,594
฿4,132 total
17 May - 18 May
includes taxes & fees
9.6/10 Exceptional! (1,005 reviews)
Everything was fantastic.

Reviewed on 3 May 2026

Drury Inn & Suites Sikeston, MO
See all 109 properties in Mississippi County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mississippi County holiday package cost?
The most affordable Mississippi County package is , so your dream getaway can become a reality — without spending an arm and a leg. Bundle flights, hotels, car rentals and more to create a package that matches your travelling style.
How do I get a cheap travel package to Mississippi County?
You'll save piles of cash if you bundle your flights, hotels and car rentals into a Mississippi County holiday package. Sometimes cheap means fewer options. But not with Expedia. We offer more than 550 partner airlines and 1,000,000 hotels across the world, so you'll always have plenty of variety to choose from. Want to save even more? Add some interesting activities to your package deal to unlock even more bargains! After all, travel is about more than simply getting to your destination.
What are the top hotels in Mississippi County?
East Prairie is one destination that most visitors to Mississippi County put on their itinerary. For a comfortable stay here, look up Super 8 by Wyndham Charleston MO and Quality Inn Charleston I-57.
How far in advance should I book my Mississippi County holiday?
Browse Expedia to compare airfares as soon as possible. In many cases, you can purchase a ticket up to 12 months prior to departure. If you don't see your preferred carrier, or you have to book last minute, fear not. Cheap fares to Mississippi County occasionally appear just weeks before the date of departure.
What does an Expedia Mississippi County travel package include?
That depends on what you're looking for. If you're travelling alone, you might decide to combine hotels and flights. Bringing the whole crew to Mississippi County? A travel package including rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility to build your own travel package.
What should I know before booking a Mississippi County travel package?
You'll enjoy amazing savings when you combine your flights, hotels and rental cars into a package. Plus, booking everything together will make your trip planning easier. So why waste your money or time? Whether you're organising a luxury romantic escape or a budget solo adventure, explore our holiday packages today.
Can I choose my airline with a Mississippi County Expedia holiday package?
Yes — that's the beauty of an Expedia package. You're the boss! We have access to more than 550 airline partners around the world, so you have loads of choice when organising your Mississippi County adventure.
If I'm not able to travel, can I cancel my Mississippi County holiday package?
Yes, you can. We totally understand that even the best-laid plans can fail, so we're happy to help if you have to make changes to your Mississippi County holiday package. It may be possible to cancel or amend your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if your booking was made more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.