Find the best Mississippi County Hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
25 Aug - 26 Aug
Tomorrow
26 Aug - 27 Aug
This weekend
29 Aug - 31 Aug
Next weekend
5 Sep - 7 Sep

Filter by

Guest rating
Guest rating
Property class

Top Hotels Mississippi County

Our top choices for Mississippi County hotels

Super 8 by Wyndham Charleston/Sikeston East MO
Front of property – evening/night

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (585)
"Rooms was clean "
The price is ฿1,873
฿2,079 total
includes taxes & fees
8 Sept - 9 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Desk, laptop workspace, blackout curtains, iron/ironing board

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (398)
"I consistently choose to stay there due to positive past encounters."
The price is ฿2,163
฿2,400 total
includes taxes & fees
7 Sept - 8 Sept
Quality Inn Charleston - Sikeston
Eagle Inn Charleston
Desk, iron/ironing board, free WiFi, alarm clocks

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
The price is ฿2,067
฿2,294 total
includes taxes & fees
2 Sept - 3 Sept
Eagle Inn Charleston
Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (264)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is ฿2,234
฿2,480 total
includes taxes & fees
11 Sept - 12 Sept
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mississippi County Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Great experience! "
Danny 1-night trip
Posted 5 days ago
Fairfield Inn & Suites by Marriott Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent
"Rooms are always clean."
Courtney 3-night trip
Posted 8 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Explore a world of travel with Expedia

Explore a world of travel with Expedia