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Search Hotels in Medical Center Area, Boston

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20 Dec - 21 Dec
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21 Dec - 22 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Medical Center Area hotels

Exterior detail
The Inn at Longwood Medical

The Inn at Longwood Medical

The Inn at Longwood Medical
3.5 star property
Medical Center Area
8.4 out of 10, Very good, (1004)
"Nice hotel in a good location. "
United States
Chrisann
The price is ฿6,381
฿8,344 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Inn at Longwood Medical
Exterior
enVision Hotel Boston Everett

enVision Hotel Boston Everett

enVision Hotel Boston Everett
2.0 star property
8.4 km from Medical Center Area
8.6 out of 10, Excellent, (1002)
"Staff was friendly and it was nice to have places to eat at"
United States
Marcelo
The price is ฿3,097
฿3,459 total
includes taxes & fees
21 Dec - 22 Dec
enVision Hotel Boston Everett
Reception
Hotel 1868

Hotel 1868

Hotel 1868
3.5 star property
5.7 km from Medical Center Area
9.4 out of 10, Exceptional, (1000)
"Great stay overall "
United States
Elisabet
The price is ฿3,580
฿4,151 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel 1868
Front of property – evening/night
Sonesta Simply Suites Boston Burlington

Sonesta Simply Suites Boston Burlington

Sonesta Simply Suites Boston Burlington
2.0 star property
19 km from Medical Center Area
9.0 out of 10, Wonderful, (140)
" Check in and out staff very nice. Great room for the price "
United States
Victoria
The price is ฿2,984
฿3,333 total
includes taxes & fees
26 Dec - 27 Dec
Sonesta Simply Suites Boston Burlington
Exterior
Nantasket Beach Resort

Nantasket Beach Resort

Nantasket Beach Resort
3.0 star property
21.1 km from Medical Center Area
8.6 out of 10, Excellent, (1000)
"Staff was delightful and rooms were cute! "
United States
Robert
The price is ฿3,742
฿4,840 total
includes taxes & fees
28 Dec - 29 Dec
Nantasket Beach Resort
Exterior
Midtown Hotel

Midtown Hotel

Midtown Hotel
2.0 star property
Prudential - St. Botolph, 1.7 km from Medical Center Area
7.4 out of 10, Good, (1006)
"A pleasant hotel, well-located, with friendly service and clean rooms."
United States
Renato Reis
The price is ฿3,252
฿3,787 total
includes taxes & fees
24 Dec - 25 Dec
Midtown Hotel
Exterior
Canopy By Hilton Boston Downtown

Canopy By Hilton Boston Downtown

Canopy By Hilton Boston Downtown
4.0 star property
Government Center, 4.7 km from Medical Center Area
9.6 out of 10, Exceptional, (1000)
"Great hotel!"
United States
Jonathan
The price is ฿3,995
฿5,932 total
includes taxes & fees
29 Dec - 30 Dec
Canopy By Hilton Boston Downtown
Front of property – evening/night
Porter Square Hotel

Porter Square Hotel

Porter Square Hotel
3.0 star property
5.8 km from Medical Center Area
9.2 out of 10, Wonderful, (1002)
"Room is perfect and girls at the front desk are super sweet & helpful!"
Canada
Leah
The price is ฿3,823
฿4,433 total
includes taxes & fees
28 Dec - 29 Dec
Porter Square Hotel
2 bars/lounges
Concord's Colonial Inn

Concord's Colonial Inn

Concord's Colonial Inn
3.0 star property
24.4 km from Medical Center Area
8.6 out of 10, Excellent, (1001)
"We loved historic inn, and its location in Concord "
United States
Kevin
The price is ฿3,675
฿4,105 total
includes taxes & fees
21 Dec - 22 Dec
Concord's Colonial Inn
Exterior
Pennyweight Hotel Boston, Curio Collection by Hilton

Pennyweight Hotel Boston, Curio Collection by Hilton

Pennyweight Hotel Boston, Curio Collection by Hilton
4.0 star property
West End, 4.5 km from Medical Center Area
8.2 out of 10, Very good, (1082)
"Room was great and check in was quick"
United States
Cheryl
The price is ฿3,900
฿5,640 total
includes taxes & fees
27 Dec - 28 Dec
Pennyweight Hotel Boston, Curio Collection by Hilton
City view from property
Newbury Guest House

Newbury Guest House

Newbury Guest House
3.0 star property
2.1 km from Medical Center Area
9.4 out of 10, Exceptional, (1000)
"Beautiful property, excellent staff!"
United States
Candace
The price is ฿4,055
฿4,661 total
includes taxes & fees
11 Jan - 12 Jan 2026
Newbury Guest House
Desk, iron/ironing board, free cots/infant beds, rollaway beds
Courtyard by Marriott Boston-Cambridge

Courtyard by Marriott Boston-Cambridge

Courtyard by Marriott Boston-Cambridge
3.5 star property
2.5 km from Medical Center Area
8.8 out of 10, Excellent, (1007)
"Great place if you are travelling for"
United States
Karim
The price is ฿2,552
฿3,965 total
includes taxes & fees
4 Jan - 5 Jan 2026
Courtyard by Marriott Boston-Cambridge
Reception
Harvard Square Hotel

Harvard Square Hotel

Harvard Square Hotel
3.0 star property
4.1 km from Medical Center Area
8.4 out of 10, Very good, (653)
"Convenient, nice staff, clean. "
United States
Sarita
Harvard Square Hotel
Interior
Staypineapple, A Delightful Hotel, South End

Staypineapple, A Delightful Hotel, South End

Staypineapple, A Delightful Hotel, South End
3.0 star property
2.8 km from Medical Center Area
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
John
The price is ฿2,516
฿3,842 total
includes taxes & fees
19 Jan - 20 Jan 2026
Staypineapple, A Delightful Hotel, South End
View from property
AC Hotel by Marriott Boston Downtown

AC Hotel by Marriott Boston Downtown

AC Hotel by Marriott Boston Downtown
3.5 star property
3.5 km from Medical Center Area
8.8 out of 10, Excellent, (1003)
"Spotless, beautiful modern furniture, great mattress "
United States
Afroditi
The price is ฿3,580
฿5,083 total
includes taxes & fees
26 Dec - 27 Dec
AC Hotel by Marriott Boston Downtown
Free daily continental breakfast
Residence Inn by Marriott Boston Downtown / South End

Residence Inn by Marriott Boston Downtown / South End

Residence Inn by Marriott Boston Downtown / South End
3.0 star property
1.9 km from Medical Center Area
8.6 out of 10, Excellent, (1001)
"Super clean and spacious room. Really lovely "
United States
Jia
The price is ฿4,095
฿4,769 total
includes taxes & fees
24 Dec - 25 Dec
Residence Inn by Marriott Boston Downtown / South End
Exterior
Hampton Inn Boston Bedford Burlington

Hampton Inn Boston Bedford Burlington

Hampton Inn Boston Bedford Burlington
2.5 star property
22.1 km from Medical Center Area
9.2 out of 10, Wonderful, (1002)
"great breakfast, helpful staff, beds a little soft for me, but my dad loved them- super convenient, will stay again!"
United States
denise
The price is ฿3,065
฿3,423 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hampton Inn Boston Bedford Burlington
Suite, Multiple Beds (John Adams Presidential Suite) | Frette Italian sheets, premium bedding, pillow-top beds, minibar
Boston Harbor Hotel

Boston Harbor Hotel

Boston Harbor Hotel
5.0 star property
4.8 km from Medical Center Area
9.8 out of 10, Exceptional, (1003)
"Love this hotel. "
United States
Alisha
The price is ฿13,664
฿15,929 total
includes taxes & fees
18 Jan - 19 Jan 2026
Boston Harbor Hotel
View from property
Sheraton Boston Needham Hotel

Sheraton Boston Needham Hotel

Sheraton Boston Needham Hotel
3.5 star property
10.3 km from Medical Center Area
8.8 out of 10, Excellent, (1525)
"Great experience amazing food"
United States
David
The price is ฿3,706
฿4,140 total
includes taxes & fees
5 Jan - 6 Jan 2026
Sheraton Boston Needham Hotel
Free daily buffet breakfast
HYATT house Boston/Waltham

HYATT house Boston/Waltham

HYATT house Boston/Waltham
3.0 star property
14.1 km from Medical Center Area
8.8 out of 10, Excellent, (1072)
"The Staff was great, the room was clean and comfortable and the breakfast was good! "
United States
Meridith
The price is ฿3,172
฿3,543 total
includes taxes & fees
16 Jan - 17 Jan 2026
HYATT house Boston/Waltham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Medical Center Area

Find the best Medical Center Area areas for the activities you enjoy most.
Downtown Boston which includes a city and night scenes as well as a small group of people

Downtown Boston

The heart of America’s revolutionary history lies in the center of this city. Uncover the story of the nation and enjoy excellent arts and dining venues.

Seaport District showing a city, a high-rise building and a river or creek

Seaport District

Join excited crowds enjoying harbor-side views, Revolutionary War-era landmarks, as well as superb restaurants and museums along this thriving waterfront.

Back Bay featuring heritage architecture, a city and street scenes

Back Bay

Parisian boulevards and elegant brownstones conjure a truly romantic atmosphere, perfect for strolling and window shopping.

Beacon Hill showing landscape views

Beacon Hill

Lose yourself in the charming streetscapes, historic buildings and village-like atmosphere of Boston’s oldest and wealthiest suburbs.

North End

The ample dining options and captivating waterfront views are just a few popular features of the neighbourhood. Make a stop by New England Aquarium or Old North Church while you're visiting, and jump aboard the metro at Aquarium to get around town.

Top Medical Center Area Hotel Reviews

The Godfrey Hotel Boston

The Godfrey Hotel Boston

10/10 Excellent
"Loved out stay at this hotel. It was my first time to Boston and it snowed. Lovely area of town, close to Boston Commons and other transportation *orange line". Accomodations were very comfortable. Housekeeping and Concierge staff were amazing."
Christine 4-night trip
Posted 2 days ago
The Godfrey Hotel Boston

Frequently asked questions

What's it like in Medical Center Area?
Guests are sure to enjoy their time checking out all that Boston's Medical Center Area neighbourhood has to offer. Make sure that you visit Isabella Stewart Gardner Museum and Warren Anatomical Museum as part of your Medical Center Area travel plans.
What's the best accommodation in Medical Center Area?
Based on Expedia customer reviews, The Inn at Longwood Medical is the highest ranked property in Medical Center Area. This hotel is a short 1-minute walk from Children's Hospital Boston, and it offers a restaurant and a fitness centre.
How many hotels will I be able to find in Medical Center Area?
When you want to put your feet up after a day of exploring the sights in Boston, you can choose from 17 Expedia hotels and other accommodation options in Medical Center Area.
If I need to cancel my hotel reservation in Medical Center Area, will I receive a refund?
Yes! Most hotel reservations are refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then you can use the "fully refundable" filter to view the best deals in Medical Center Area.
What can I see and do in this Boston neighbourhood?
Sights like Isabella Stewart Gardner Museum and Warren Anatomical Museum can be part of your cultural tour of Medical Center Area. When you're sightseeing in Boston, Fenway Park and Copley Square are also worth a stop.
How can I get around Medical Center Area and the greater Boston area?
If you want to see more of the city, Longwood Medical Area Station is the closest metro stop. Others nearby include Brigham Circle Station and Museum of Fine Arts Station.