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21c Museum Hotel Louisville

4.5 star property
Luxury hotel with full-service spa and 24-hour fitness centre

Choose dates to view prices

Travelers find art and luxury at 21c Museum Hotel Louisville. Enjoy rejuvenating massages at the spa, breakfast and dinner at Proof on Main, a 24-hour gym, and dry cleaning services. Attentive staff handle every need to ensure guests look their best.

Reviews

9.2 out of 10
Wonderful

Popular amenities

  • Spa
  • Bar
  • Room service
The current price is ฿5,208
฿6,290 total
includes taxes & fees
20 Nov - 21 Nov

Room options

Available filters for rooms
Showing 12 of 12 rooms

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down duvets, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(29 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 31 sq m
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down duvets, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 40 sq m
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down duvets, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(65 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 33 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down duvets, minibar, in-room safe

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(32 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 42 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down duvets, minibar, in-room safe

Suite, Corner

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 61 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe

Room (Asleep in the Cyclone)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 46 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down duvets, minibar, in-room safe

Suite (Atrium)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 54 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down duvets, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)

Highlights

Furnished balcony or patio
Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
  • 29 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 42 sq m
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down duvets, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 40 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down duvets, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Highlights

Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
Down duvet
  • 40 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down duvets, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

Highlights

Furnished balcony or patio
Soundproofed
Air conditioning
Connecting rooms available
Free cots/infant beds
HDTV
Hypo-allergenic bedding
Blackout curtains
  • Sleeps 4
  • 1 Double Bed

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About the area

Map
700 W Main Street, Louisville, KY, 40202

What's nearby

  • Muhammad Ali Center - 3 min walk - 0.3 km
  • Louisville Slugger Museum - 3 min walk - 0.3 km
  • Fourth Street Live! - 8 min walk - 0.7 km
  • Kentucky International Convention Center - 8 min walk - 0.7 km
  • KFC Yum Center - 8 min walk - 0.7 km

Getting around

  • Louisville International Airport (SDF) - 10 min drive

Restaurants

  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Pokehana - ‬5 min walk

About this property

21c Museum Hotel Louisville

Luxury boutique hotel near KFC Yum Center
Close to Louisville Slugger Museum and Kentucky International Convention Center, 21c Museum Hotel Louisville provides dry cleaning/laundry services, a bar and a 24-hour gym. Treat yourself to a massage at the on-site spa. The on-site restaurant, Proof on Main, offers breakfast, brunch, lunch and dinner. In addition to a 24-hour business centre, guests can connect to free in-room WiFi.
You'll also enjoy perks such as:
  • Limo/town car service, full breakfast (surcharge) and valet parking (surcharge)
  • An electric car charging station, ATM/banking services and massage treatment rooms
  • Luggage storage, meeting rooms and multilingual staff
  • Guest reviews say great things the dining options, helpful staff and location
Room features
All 91 rooms include comforts, such as premium bedding and laptop-compatible safes, in addition to perks, such as laptop-friendly workspaces and air conditioning. Guest reviews speak positively of the cleanliness rooms at the property.
More conveniences in all rooms include:
  • LED light bulbs and eco-friendly cleaning products
  • Bathrooms with designer toiletries and hairdryers
  • 50-inch HDTVs with premium channels
  • Wardrobes/cupboards, free infant beds and daily housekeeping

Awards and affiliations

Eco-certified property
This property participates in Green Key Global – a programme that measures the property's impact on one or more of the following: environment, community, cultural heritage and the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transport

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Daily full breakfast available for a fee: USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room cot
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Free newspapers in lobby
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance
  • Turndown service

Business services

  • 24-hour business centre
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • In-room massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Lift
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • At least 80% lighting from LEDs
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • Built in 2006
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free cot
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Designer toiletries
  • Dressing gowns
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • IPod dock

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; check-in end time: midnight
Contactless check-in and check-out are available
Minimum check-in age - 21

Check-out

Check-out before 11 AM
Contactless check-out

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 40.00 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Up to 23 kg per pet
Food and water bowls are available

Children and extra beds

Children are welcome
Rollaway/extra beds are available for USD 30.0 per night.
Free cots are available on request at the property

Payment types at the property

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
21c Museum Louisville Mgallery
21c Museum Louisville
21c Museum Hotel Louisville Hotel
21c Museum Hotel Louisville MGallery
21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

Is 21c Museum Hotel Louisville pet-friendly?

Yes, this hotel allows pets with a maximum weight of up to 23 kg per pet. There's a fee of USD 40.00 per accommodation, per stay. Service animals are exempt from fees.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of 4 Nov 2025, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on 20 Nov 2025 start from ฿5,208.36, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking at 21c Museum Hotel Louisville?

Valet parking is available for USD 32 per night.

What time is check-in at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; check-in end time: midnight.

What time is check-out at 21c Museum Hotel Louisville?

Checkout is at 11 AM.

Where is 21c Museum Hotel Louisville located?

Located in Downtown Louisville, this luxury hotel is steps away from 21c Museum Hotel, Ohio River Valley and Louisville Slugger Museum. KFC Yum Center and Fourth Street Live! are also within 10 minutes.

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Reviews

21c Museum Hotel Louisville Reviews

9.2

Wonderful

9.6

Cleanliness

9.2

Location

9.4

Staff & service

9.2

Eco-friendliness

9.6

Property conditions & facilities
Rating 10 - Excellent. 760 out of 1002 reviews
Rating 8 - Good. 138 out of 1002 reviews
Rating 6 - Okay. 61 out of 1002 reviews
Rating 4 - Poor. 23 out of 1002 reviews
Rating 2 - Terrible. 20 out of 1002 reviews

Reviews

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, property conditions & facilities
Room was very clean and staff were very friendly.
Stayed 1 night in Sep 2025

10/10 Excellent

Robin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21c Museum Hotel is a fun and unique experience. Beautiful rooms and centrally located to shops, restaurants and distilleries in Louisville.
Stayed 2 nights in Oct 2025

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing location and great hotel. Staff was great. Restaurant was delicious. Great location on Main Street!!
Stayed 4 nights in Sep 2025

10/10 Excellent

earl

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfect location for walking Louisville
Stayed 4 nights in Oct 2025

10/10 Excellent

Jeffrey

Liked: Cleanliness, staff & service, property conditions & facilities
I would definitely stay again at this chic hotel chain
Stayed 1 night in Sep 2025

10/10 Excellent

JULIA

Liked: Cleanliness, staff & service, property conditions & facilities
What a cool place to stay! It is an art museum. Nice, large room, quiet and very good restaurant. Perfect location for all we wanted to do.
Stayed 1 night in Aug 2025

10/10 Excellent

Tom

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location. Great hotel. Great team members.
Stayed 2 nights in Jul 2025

10/10 Excellent

Britney

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Very cool hotel

Great hotel in the heart of the Bourbon Trail, loved the big rooms, art and the smiling door man.
Stayed 3 nights in Jun 2025

8/10 Good

Thomas

Liked: Cleanliness, amenities, property conditions & facilities
Front desk and valets were great. But our room wasn't serviced, which makes the stay less comfortable.
Stayed 2 nights in Oct 2025

10/10 Excellent

Jessica

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel to stay near plenty to do. Clean, comfortable, friendly staff!
Stayed 2 nights in Mar 2025

8/10 Good

mark

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Price was too high compared to similar hotels.
Stayed 2 nights in Sep 2025

10/10 Excellent

Han

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We were able to check in early. Room is clean and breakfast is great.
Stayed 1 night in May 2025

10/10 Excellent

Carol

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Very fun Hotel with a really nice sub art and Exhibits and great location for walking the Louisville downtown. We definitely recommend staying here and we will stay here again.
Stayed 2 nights in Apr 2025

10/10 Excellent

Rachel

Liked: Cleanliness, amenities, property conditions & facilities
All around great experience.
Stayed 3 nights in Jun 2025

10/10 Excellent

Sybil

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was great, ver helpful with answering questions about the city. Restaurant had good food and atmosphere. Loved being surrounded by so many wonderful works of art. We would definitely stay again... it's such a vibe.
Stayed 3 nights in Jun 2025

6/10 Okay

Barrett

Liked: Cleanliness, staff & service
This is a pretty decent hotel that I’ve stayed in many times and enjoyed myself. This time I felt a bit disappointed with the room I was in
Stayed 1 night in Sep 2025

10/10 Excellent

CHER

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Love 21C perfect hotel. In gorgeous downtown Louisville
Stayed 3 nights in May 2025

10/10 Excellent

Kathryn

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The art gallery was fun. Parking was rough but I chose to do valet and that took care of it. It was pricey but worth it to not have to battle finding parking in the area. The hotel was beautiful and so fun and unique. Close to everything!
Stayed 1 night in Jul 2025

10/10 Excellent

Joon

Liked: Cleanliness, staff & service, property conditions & facilities
Nice modern facility with quirky museum in side the hotel. Fun little boutique hotel.
Stayed 1 night in Dec 2024

10/10 Excellent

Nithin Kumar Reddy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Great stay in downtown

Wonderful stay in a downtown location within walking distance of many museums and situated in a safe area. The rooms were spacious and spotless, and the hotel staff was friendly and accommodating.
Stayed 1 night in Dec 2024

10/10 Excellent

Deron

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Really comfortable with nice room service
Stayed 2 nights in Nov 2024

10/10 Excellent

John

Liked: Property conditions & facilities
Beautiful hotel. Very clean and nicely furnished. Loved the open art gallery area. Nice bar for nightcap. Walkable to many tourist attractions.
Stayed 1 night in Jan 2025

10/10 Excellent

Harry

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Best of LuiisvilleLouisville

Great hotels.
Stayed 1 night in Apr 2024

10/10 Excellent

Pierce

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Our stay was amazing. The hospitality was tremendous. The hotel and people that work their do a great job at making you feel welcomed and taken care of.
Stayed 4 nights in Mar 2024

10/10 Excellent

Deborah

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff were fantastic and amazing art museum
Stayed 10 nights in May 2024