South Main Travel Guide

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Things to do

Picture 3 for Activity Houston: Space Center Houston Admission Ticket

Houston: Space Center Houston Admission Ticket

฿1,000
per adult
92% of travellers recommend
Houston: Space Center Houston Admission Ticket
Houston Museum of Natural Sciences: Planetarium Ticket

Houston Museum of Natural Sciences: Planetarium Ticket

฿401
per adult
82% of travellers recommend
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Holocaust Museum Houston Entry Ticket

Houston: Holocaust Museum Houston Entry Ticket

฿735
per adult
90% of travellers recommend
Houston: Holocaust Museum Houston Entry Ticket
Viral Drip Bear Painting w/ RnB & Hip Hop Tunes

Viral Drip Bear Painting w/ RnB & Hip Hop Tunes

฿1,502
per adult
Viral Drip Bear Painting w/ RnB & Hip Hop Tunes
HOP ON- HOP OFF

Houston's Official City & Mural Tour!

฿1,334
per adult
88% of travellers recommend
Houston's Official City & Mural Tour!
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

฿401
per adult
74% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
See all activities in Houston

Top hotels in South Main

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is ฿4,139 per night from 6 Nov to 7 Nov
฿4,139
฿4,843 total
6 Nov - 7 Nov
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and on-site spa services. Our guests praise the helpful staff and ...
Wyndham Houston at Reliant Park & Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
The price is ฿3,307 per night from 8 Nov to 9 Nov
฿3,307
฿3,869 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
Club Quarters Hotel Downtown, Houston
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
The price is ฿4,692 per night from 30 Nov to 1 Dec
฿4,692
฿5,490 total
30 Nov - 1 Dec
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and ...
8.6/10 Excellent! (2,477 reviews)
"This place has been completely overhauled every square inch. Upgraded to modern room standards. A great choice for this location for a stay."

Reviewed on 30 Oct 2026

The Whitehall Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
The price is ฿3,786 per night from 27 Nov to 28 Nov
฿3,786
฿4,461 total
27 Nov - 28 Nov
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
The price is ฿4,352 per night from 25 Nov to 26 Nov
฿4,352
฿5,092 total
25 Nov - 26 Nov
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service and a 24-hour health club. Our guests praise the helpful staff and ...
The Royal Sonesta Houston Galleria
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
The price is ฿2,593 per night from 29 Nov to 30 Nov
฿2,593
฿3,073 total
29 Nov - 30 Nov
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in their reviews. ...
Hilton Houston Plaza/Medical Center
See all 7,528 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

South Main Travel Guide