South Main Travel Guide

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Things to do

Houston Museum of Natural Sciences: Planetarium Ticket

Houston Museum of Natural Sciences: Planetarium Ticket

฿402
per adult
80% of travellers recommend
Houston Museum of Natural Sciences: Planetarium Ticket
Picture 3 for Activity Houston: Space Center Houston Admission Ticket

Houston: Space Center Houston Admission Ticket

฿1,002
per adult
92% of travellers recommend
Houston: Space Center Houston Admission Ticket
Houston: Holocaust Museum Houston Entry Ticket

Houston: Holocaust Museum Houston Entry Ticket

฿736
per adult
90% of travellers recommend
Houston: Holocaust Museum Houston Entry Ticket
HOP ON- HOP OFF

Houston's Official City & Mural Tour!

฿1,504
per adult
88% of travellers recommend
Houston's Official City & Mural Tour!
The Official Houston City Tour

NASA's Space Center & Official Houston City Tour with tickets

฿3,647
per adult
92% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
Viral Drip Bear Painting Experience

Viral Drip Bear Painting Experience

฿1,171
per adult
Viral Drip Bear Painting Experience
See all activities in Houston

Top hotels in South Main

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is ฿3,096 per night from 2 Aug to 3 Aug
฿3,096
฿3,622 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and a 24-hour front desk. Our guests praise the helpful staff and ...
Wyndham Houston near NRG Park/Medical Center
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
The price is ฿3,676 per night from 9 Aug to 10 Aug
฿3,676
฿4,340 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in their reviews. ...
Hilton Houston Plaza/Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
The price is ฿3,915 per night from 26 Jul to 27 Jul
฿3,915
฿4,581 total
26 Jul - 27 Jul
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
8.6/10 Excellent! (4,364 reviews)
"Excellent accommodations and superb staff."

Reviewed on 22 Jul 2026

Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
The price is ฿4,309 per night from 31 Jul to 1 Aug
฿4,309
฿5,077 total
31 Jul - 1 Aug
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Marriott Marquis Houston

Marriott Marquis Houston

4 out of 5
1777 Walker Street Houston TX
The price is ฿8,735 per night from 30 Jul to 31 Jul
฿8,735
฿11,186 total
30 Jul - 31 Jul
includes taxes & fees
Stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa and 4 restaurants. Our guests praise the pool and the helpful staff in their reviews. ...
9/10 Wonderful! (1,167 reviews)
"Great staff, excellent amenities, only thing I did not like was the required $25 per day charge to spend on food/drink. Also the area surrounding the hotel was not very safe, but that does not reflect on the hotel itself. Very family friendly."

Reviewed on 22 Jul 2026

Marriott Marquis Houston
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
The price is ฿4,721 per night from 21 Aug to 22 Aug
฿4,721
฿5,523 total
21 Aug - 22 Aug
includes taxes & fees
Stay at this spa hotel in Houston. Enjoy a full-service spa, 2 bars/lounges and a rooftop terrace. Our guests praise the pool and the helpful staff in their ...
Blossom Hotel Houston, Curio Collection by Hilton
See all 7,297 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

South Main Travel Guide