South Main Travel Guide

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Things to do

Picture 3 for Activity Houston: Space Center Houston Admission Ticket

Houston: Space Center Houston Admission Ticket

฿982
per adult
92% of travellers recommend
Houston: Space Center Houston Admission Ticket
Houston Museum of Natural Sciences: Planetarium Ticket

Houston Museum of Natural Sciences: Planetarium Ticket

฿394
per adult
82% of travellers recommend
Houston Museum of Natural Sciences: Planetarium Ticket
Houston Museum of Natural Science: Cockrell Butterfly Center

Houston Museum of Natural Science: Butterfly Center Ticket

฿492
per adult
100% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
Houston: Holocaust Museum Houston Entry Ticket

Houston: Holocaust Museum Houston Entry Ticket

฿722
per adult
90% of travellers recommend
Houston: Holocaust Museum Houston Entry Ticket
The Official Houston City Tour

NASA's Space Center & Official Houston City Tour with tickets

฿3,245
per adult
92% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
HOP ON- HOP OFF

Houston's Official City & Mural Tour!

฿1,310
per adult
88% of travellers recommend
Houston's Official City & Mural Tour!
See all activities in Houston

Top hotels in South Main

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is ฿3,123 per night from 24 Sept to 25 Sept
฿3,123
฿3,654 total
24 Sept - 25 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and a 24-hour front desk. Our guests praise the helpful staff and ...
7.2/10 Good! (1,407 reviews)
"On site Restaurant/Bar and great proximity to the stadium"

Reviewed on 15 Sept 2026

Wyndham Houston at Reliant Park & Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
The price is ฿4,038 per night from 27 Sept to 28 Sept
฿4,038
฿4,758 total
27 Sept - 28 Sept
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
8.4/10 Very good! (4,507 reviews)
"Good"

Reviewed on 15 Sept 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
The price is ฿8,653 per night from 25 Sept to 26 Sept
฿8,653
฿11,430 total
25 Sept - 26 Sept
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...
9.2/10 Wonderful! (1,006 reviews)
"Staff was great! Love the Za Za!"

Reviewed on 13 Sept 2026

Hotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
The price is ฿3,231 per night from 28 Sept to 29 Sept
฿3,231
฿3,780 total
28 Sept - 29 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
8.6/10 Excellent! (4,493 reviews)
"This was a great value for the price, and a great downtown location also. Smooth check-in and friendly staff."

Reviewed on 15 Sept 2026

Club Quarters Hotel Downtown, Houston
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
The price is ฿4,664 per night from 27 Sept to 28 Sept
฿4,664
฿5,457 total
27 Sept - 28 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and ...
8.6/10 Excellent! (2,393 reviews)
"Enjoyable short stay, I enjoyed the room size and hotel amenities"

Reviewed on 15 Sept 2026

The Whitehall Houston
Hyatt Regency Houston West

Hyatt Regency Houston West

3.5 out of 5
13210 Katy Fwy Houston TX
The price is ฿3,146 per night from 19 Sept to 20 Sept
฿3,146
฿3,681 total
19 Sept - 20 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the restaurant and the helpful staff ...
Hyatt Regency Houston West
See all 7,491 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A large rectangular reflecting pool with a tall building in the background.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

South Main Travel Guide